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    MAL12 alpha-glucosidase MAL12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853209, updated on 17-May-2024

    Summary

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    Gene symbol
    MAL12
    Gene description
    alpha-glucosidase MAL12
    Primary source
    FungiDB:YGR292W
    Locus tag
    YGR292W
    See related
    SGD:S000003524; AllianceGenome:SGD:S000003524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glucan 1,4-alpha-maltotriohydrolase activity; maltose alpha-glucosidase activity; and sucrose alpha-glucosidase activity. Involved in maltose catabolic process and sucrose catabolic process. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to several human genes including SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MAL12 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1076599..1078353)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription factor MAL13 Neighboring gene alpha-glucoside permease Neighboring gene seripauperin PAU12 Neighboring gene Cos6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of the molecular interactions of 7'-carboxyalkyl apigenin derivatives with S. cerevisiae α-glucosidase. Qi YJ, et al. Comput Biol Chem, 2017 Apr. PMID 28131019
    2. Novel glycoside of vanillyl alcohol, 4-hydroxy-3-methoxybenzyl-α-D-glucopyranoside: study of enzymatic synthesis, in vitro digestion and antioxidant activity. Veličković D, et al. Bioprocess Biosyst Eng, 2012 Sep. PMID 22307809
    3. A novel competitive class of α-glucosidase inhibitors: (E)-1-phenyl-3-(4-styrylphenyl)urea derivatives. Kim JY, et al. Chembiochem, 2010 Oct 18. PMID 20827790
    4. Alpha-glucosidase folding during urea denaturation: enzyme kinetics and computational prediction. Wu XQ, et al. Appl Biochem Biotechnol, 2010 Mar. PMID 19418260
    5. Gene dosage effects on the synthesis of maltase in yeast. Mowshowitz DB. J Bacteriol, 1979 Mar. PMID 374342, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural changes in alpha-glucosidase during urea denaturation, was investigated.
      Title: Alpha-glucosidase folding during urea denaturation: enzyme kinetics and computational prediction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucan 1,4-alpha-maltotriohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucan 1,4-alpha-maltotriohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables maltose alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables maltose alpha-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables maltose alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligo-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sucrose alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sucrose alpha-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in disaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maltose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maltose catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maltose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sucrose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sucrose catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    alpha-glucosidase MAL12
    NP_011808.3
    • Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1076599..1078353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181421.3 → NP_011808.3  TPA: alpha-glucosidase MAL12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011808.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV67, P53341
      UniProtKB/TrEMBL
      A6ZUU5, C7GT48, E1AFY8, F8LG06, G2WF18
      Conserved Domains (2) summary
      cd11333
      Location:15 → 501
      AmyAc_SI_OligoGlu_DGase; Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins
      pfam16657
      Location:511 → 583
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53341.1

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