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    Obp83b Odorant-binding protein 83b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40738, updated on 10-May-2024

    Summary

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    Official Symbol
    Obp83bprovided by FlyBase
    Official Full Name
    Odorant-binding protein 83bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010403
    Locus tag
    Dmel_CG11422
    See related
    AllianceGenome:FB:FBgn0010403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    83b; CG11422; DmelObp83b; Dmel\CG11422; obp83b; OBP83b; Os-E; OS-E; PBP-H1
    Summary
    Predicted to enable odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Is expressed in antenna; antennal sense organ; and eo support cell. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Obp83b in Genome Data Viewer
    Location:
    83D1-83D1; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5976177..5976817, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1801899..1802539, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long noncoding RNA: testis-specific 20 Neighboring gene Odorant-binding protein 83a Neighboring gene long non-coding RNA:CR44927 Neighboring gene long non-coding RNA:CR44928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coexpression of two odorant-binding protein homologs in Drosophila: implications for olfactory coding. Hekmat-Scafe DS, et al. J Neurosci, 1997 Mar 1. PMID 9030621, Free PMC Article
    2. Molecular evolution of odorant-binding protein genes OS-E and OS-F in Drosophila. Hekmat-Scafe DS, et al. Genetics, 2000 May. PMID 10790388, Free PMC Article
    3. Robust olfactory responses in the absence of odorant binding proteins. Xiao S, et al. Elife, 2019 Oct 25. PMID 31651397, Free PMC Article
    4. Divergent evolution and molecular adaptation in the Drosophila odorant-binding protein family: inferences from sequence variation at the OS-E and OS-F genes. Sánchez-Gracia A, et al. BMC Evol Biol, 2008 Nov 27. PMID 19038039, Free PMC Article
    5. Unusual pattern of nucleotide sequence variation at the OS-E and OS-F genomic regions of Drosophila simulans. Sánchez-Gracia A, et al. Genetics, 2007 Apr. PMID 17277360, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Odorant activation kinetics is not altered in null mutants. Unexpected phenotype associated with the null mutation implicates Obp83b in the deactivation of odorant responses. Obp83b is functionally redundant.
      Title: Odor-Specific Deactivation Defects in a Drosophila Odorant-Binding Protein Mutant.
    2. Positive selection was likely involved in the functional diversification of the OS-E and OS-F genes after the gene duplication event.
      Title: Divergent evolution and molecular adaptation in the Drosophila odorant-binding protein family: inferences from sequence variation at the OS-E and OS-F genes.
    3. Variation in the OS-E gene region exhibited an unusual and distinctive pattern: (i) a relatively high number of fixed amino acid replacements in the encoded protein and (ii) a peak of nucleotide polymorphism around the OS-E gene
      Title: Patterns of nucleotide polymorphism and divergence in the odorant-binding protein genes OS-E and OS-F: analysis in the melanogaster species subgroup of Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables odorant binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables odorant binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sensory perception of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Odorant-binding protein 83b
    Names
    CG11422-PA
    Obp83b-PA
    Olfactory-specific E
    Os-E
    Pheromone-binding protein homolog 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5976177..5976817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079518.3 → NP_524242.2  Odorant-binding protein 83b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524242.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91684, Q23970, Q9VNK3
      UniProtKB/TrEMBL
      F3YDK1
      Related
      FBpp0078304
      Conserved Domains (1) summary
      pfam01395
      Location:28 → 133
      PBP_GOBP; PBP/GOBP family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23970.2 Q23970

    Gene LinkOut

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