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    Lyz2 lysozyme 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25211, updated on 30-Sep-2021

    Summary

    Official Symbol
    Lyz2provided by RGD
    Official Full Name
    lysozyme 2provided by RGD
    Primary source
    RGD:3026
    See related
    EnsemblRapid:ENSRNOG00000005825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lyz; Lysz; Lyz1
    Summary
    widely expressed; may mediate analgesic, anti-inflammatory, hemostatic, anti-allergy, anticancer, |and antibiotic functions [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 51113.8) and Spleen (RPKM 4301.1) See more
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    Genomic context

    See Lyz2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52906810..52912154, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (60335968..60341264, complement)

    Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 9530003J23 Neighboring gene lysozyme C type 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene cleavage and polyadenylation specific factor 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysozyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lysozyme activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables lysozyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cytolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in killing of cells of other organism ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retina homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in rough endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lysozyme C-1
    Names
    1,4-beta-N-acetylmuramidase C
    NP_036903.2
    XP_038934368.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012771.3NP_036903.2  lysozyme C-1 precursor

      See identical proteins and their annotated locations for NP_036903.2

      Status: PROVISIONAL

      Source sequence(s)
      BC058490
      UniProtKB/TrEMBL
      Q6PDV1
      Conserved Domains (1) summary
      smart00263
      Location:19147
      LYZ1; Alpha-lactalbumin / lysozyme C

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

      Range
      52906810..52912154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078440.1XP_038934368.1  lysozyme C-1 isoform X1

      Related
      ENSRNOP00000007747.5, ENSRNOT00000007747.8
      Conserved Domains (1) summary
      smart00263
      Location:19191
      LYZ1; Alpha-lactalbumin / lysozyme C
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