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    Bpgm bisphosphoglycerate mutase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296973, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Bpgmprovided by RGD
    Official Full Name
    bisphosphoglycerate mutaseprovided by RGD
    Primary source
    RGD:735018
    See related
    Ensembl:ENSRNOG00000010133 AllianceGenome:RGD:735018
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab2-098
    Summary
    Predicted to enable bisphosphoglycerate mutase activity; hydrolase activity; and phosphoglycerate mutase activity. Involved in erythrocyte development. Human ortholog(s) of this gene implicated in familial erythrocytosis 8. Orthologous to human BPGM (bisphosphoglycerate mutase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 880.3), Muscle (RPKM 473.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64106809..64135749)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63139730..63168581)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (61912210..61940697)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 6, pseudogene 4 Neighboring gene aldo-keto reductase family 1, member B7 Neighboring gene caldesmon 1 Neighboring gene uncharacterized LOC120102254 Neighboring gene AGBL carboxypeptidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Changes in enzyme activities involved in the degradation of 1,3-bisphosphoglycerate during erythropoiesis in rat bone marrow. Pineda M, et al. Cell Biochem Funct, 1984 Oct. PMID 6097373
    2. Compound heterozygosity in a complete erythrocyte bisphosphoglycerate mutase deficiency. Lemarchandel V, et al. Blood, 1992 Nov 15. PMID 1421379
    3. Isolation, characterization, and structure of a mutant 89 Arg----Cys bisphosphoglycerate mutase. Implication of the active site in the mutation. Rosa R, et al. J Biol Chem, 1989 May 15. PMID 2542247
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bisphosphoglycerate mutase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleoside phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oxygen transport ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bisphosphoglycerate mutase
    Names
    2,3-bisphosphoglycerate mutase
    NP_955414.1
    XP_006236321.1
    XP_038963221.1
    XP_063141817.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199382.2 → NP_955414.1  bisphosphoglycerate mutase

      See identical proteins and their annotated locations for NP_955414.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      F7F6N0, Q6P6G4
      Related
      ENSRNOP00000013566.4, ENSRNOT00000013569.5
      Conserved Domains (1) summary
      cl11399
      Location:4 → 253
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      64106809..64135749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107293.2 → XP_038963221.1  bisphosphoglycerate mutase isoform X1

      UniProtKB/TrEMBL
      F7F6N0, Q6P6G4
      Conserved Domains (1) summary
      cl11399
      Location:4 → 253
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    2. XM_063285747.1 → XP_063141817.1  bisphosphoglycerate mutase isoform X1

      UniProtKB/TrEMBL
      F7F6N0, Q6P6G4

    3. XM_006236259.5 → XP_006236321.1  bisphosphoglycerate mutase isoform X1

      See identical proteins and their annotated locations for XP_006236321.1

      UniProtKB/TrEMBL
      F7F6N0, Q6P6G4
      Conserved Domains (1) summary
      cl11399
      Location:4 → 253
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein Strain
    Heading Accession and Version

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