prpf19 pre-mRNA processing factor 19 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prpf19provided by ZNC
Official Full Name: pre-mRNA processing factor 19provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-263
See related: Ensembl:ENSDARG00000015239 AllianceGenome:ZFIN:ZDB-GENE-030131-263
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: prp19; NMP200; fb18f09; zgc:56158; wu:fb18f09
Summary: Predicted to enable ubiquitin-protein transferase activity. Acts upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to be located in lipid droplet; nucleus; and spindle. Predicted to be part of Prp19 complex and U2-type catalytic step 1 spliceosome. Predicted to be active in cytoplasm. Orthologous to human PRPF19 (pre-mRNA processing factor 19). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (16288119..16301402)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (15982466..15995749)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA damage response, signal transduction by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Prp19 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Prp19 complex	IEA Inferred from Electronic Annotation more info
part_of U2-type catalytic step 1 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pre-mRNA-processing factor 19

Names: PRP19/PSO4 homolog; nuclear matrix protein NMP200 related to splicing factor PRP19

NP_958875.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201467.1 → NP_958875.1 pre-mRNA-processing factor 19

See identical proteins and their annotated locations for NP_958875.1

Status: PROVISIONAL

Source sequence(s)

BC045954

UniProtKB/TrEMBL

B2GRR4, F6NRG9, Q7ZV92

Related

ENSDARP00000097371.3, ENSDART00000106593.5

Conserved Domains (5) summary

smart00504
Location:2 → 60

Ubox; Modified RING finger domain

COG2319
Location:225 → 505

WD40; WD40 repeat [General function prediction only]

cd00200
Location:224 → 504

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08606
Location:69 → 132

Prp19; Prp19/Pso4-like

sd00039
Location:225 → 263

7WD40; WD40 repeat [structural motif]