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    CREM cAMP responsive element modulator [ Gallus gallus (chicken) ]

    Gene ID: 378903, updated on 3-Apr-2024

    Summary

    Symbol
    CREMprovided by CGNC
    Full Name
    cAMP responsive element modulatorprovided by CGNC
    Primary source
    CGNC:49136
    See related
    Ensembl:ENSGALG00010004425
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ICER
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (12931761..12963477, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (12959698..12991338, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene gap junction protein delta 4 Neighboring gene cyclin Y Neighboring gene uncharacterized LOC107052602 Neighboring gene translation initiation factor IF-2-like Neighboring gene cullin 2 Neighboring gene par-3 family cell polarity regulator

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    cAMP-responsive element modulator

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278132.1NP_001265061.1  cAMP-responsive element modulator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BU485989, BX931695, BX934897, CN234043, CN235463
      Conserved Domains (2) summary
      cd14690
      Location:238292
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:65102
      pKID; pKID domain
    2. NM_001278133.2NP_001265062.1  cAMP-responsive element modulator isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000036
      UniProtKB/TrEMBL
      F1N847
      Conserved Domains (2) summary
      cd14690
      Location:223277
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5087
      pKID; pKID domain
    3. NM_001278134.1NP_001265063.1  cAMP-responsive element modulator isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the UTRs and coding region, compared to variant 1, including the lack of multiple 3' coding exons. It initiates translation at a downstream in-frame start codon. The encoded isoform (3) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BX930447, CN232429
      Conserved Domains (1) summary
      pfam02173
      Location:5087
      pKID; pKID domain
    4. NM_001278135.2NP_001265064.1  cAMP-responsive element modulator isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks multiple 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000036
      Conserved Domains (1) summary
      cd14690
      Location:69123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    5. NM_204387.3NP_989718.2  cAMP-responsive element modulator isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the UTRs and coding region, compared to variant 1, including the lack of multiple 5' coding exons. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (4) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      JAENSK010000036
      UniProtKB/TrEMBL
      Q7T3L4, R4GII4
      Conserved Domains (1) summary
      cd14690
      Location:69123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      12931761..12963477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046917410.1XP_046773366.1  cAMP-responsive element modulator isoform X4

    2. XM_015281264.4XP_015136750.1  cAMP-responsive element modulator isoform X3

      UniProtKB/TrEMBL
      F1N847
      Conserved Domains (2) summary
      cd14690
      Location:223277
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5087
      pKID; pKID domain
    3. XM_015281263.4XP_015136749.1  cAMP-responsive element modulator isoform X2

      Conserved Domains (2) summary
      cd14690
      Location:238292
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:65102
      pKID; pKID domain
    4. XM_015281262.4XP_015136748.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A1D5PT13
      Related
      ENSGALP00010006044.1, ENSGALT00010010339.1
      Conserved Domains (2) summary
      cd14690
      Location:238292
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:65102
      pKID; pKID domain
    5. XM_046917407.1XP_046773363.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A1D5PT13
    6. XM_046917416.1XP_046773372.1  cAMP-responsive element modulator isoform X5

    7. XM_046917423.1XP_046773379.1  cAMP-responsive element modulator isoform X6

    8. XM_025147004.3XP_025002772.1  cAMP-responsive element modulator isoform X6

      UniProtKB/TrEMBL
      Q7T3L4, R4GII4
      Conserved Domains (1) summary
      cd14690
      Location:3993
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      12959698..12991338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910220.1XP_046766176.1  cAMP-responsive element modulator isoform X4

    2. XM_046910219.1XP_046766175.1  cAMP-responsive element modulator isoform X3

    3. XM_046910217.1XP_046766173.1  cAMP-responsive element modulator isoform X2

    4. XM_046910216.1XP_046766172.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A1D5PT13
    5. XM_046910218.1XP_046766174.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A1D5PT13
    6. XM_046910221.1XP_046766177.1  cAMP-responsive element modulator isoform X5

    7. XM_046910223.1XP_046766179.1  cAMP-responsive element modulator isoform X6

    8. XM_046910222.1XP_046766178.1  cAMP-responsive element modulator isoform X6