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    sp100.3 SP110 nuclear antigen, tandem duplicate 3 [ Danio rerio (zebrafish) ]

    Gene ID: 555649, updated on 27-Mar-2024

    Summary

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    Official Symbol
    sp100.3provided by ZNC
    Official Full Name
    SP110 nuclear antigen, tandem duplicate 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-130530-997
    See related
    Ensembl:ENSDARG00000090449 AllianceGenome:ZFIN:ZDB-GENE-130530-997
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-68o6.4
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in membrane and nucleus. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in hepatic venoocclusive disease with immunodeficiency and tuberculosis. Orthologous to several human genes including SP110 (SP110 nuclear body protein) and SP140L (SP140 nuclear body protein like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (24571183..24589713)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (24440638..24459164)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene SP110 nuclear antigen, tandem duplicate 1 Neighboring gene nuclear body protein SP140-like Neighboring gene si:dkey-68o6.5 Neighboring gene si:dkey-68o6.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sp110 nuclear body protein
    Names
    SP110 nuclear body protein, tandem duplicate 3
    sp110 nuclear body protein-like
    zmp:0000000994

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      24571183..24589713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473617.1 → XP_021329292.1  sp110 nuclear body protein

      UniProtKB/TrEMBL
      A0A8M9PDW0, E7F805
      Related
      ENSDARP00000108373.1, ENSDART00000123017.3
      Conserved Domains (4) summary
      cd15541
      Location:428 → 471
      PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
      pfam01342
      Location:327 → 401
      SAND; SAND domain
      pfam03172
      Location:12 → 108
      HSR; HSR domain
      cl02556
      Location:499 → 598
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394532.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      49031..67561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_678217.7 → XP_683309.3  sp110 nuclear body protein

      UniProtKB/TrEMBL
      A0A8M9PDW0, E7F805
      Conserved Domains (4) summary
      cd15541
      Location:428 → 471
      PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
      pfam01342
      Location:327 → 401
      SAND; SAND domain
      pfam03172
      Location:12 → 108
      HSR; HSR domain
      cl02556
      Location:499 → 598
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    Nucleotide Protein
    Heading Accession and Version

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