IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 [Gallus gallus (chicken)] - Gene

Summary

Symbol: IGF2BP3provided by CGNC
Full Name: insulin like growth factor 2 mRNA binding protein 3provided by CGNC
Primary source: CGNC:51304
See related: Ensembl:ENSGALG00010001476
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: VICKZ3
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (31057514..31164938, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (31103377..31210878, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-9-5p Inhibits Skeletal Muscle Satellite Cell Proliferation and Differentiation by Targeting IGF2BP3 through the IGF2-PI3K/Akt Signaling Pathway.
Title: miR-9-5p Inhibits Skeletal Muscle Satellite Cell Proliferation and Differentiation by Targeting IGF2BP3 through the IGF2-PI3K/Akt Signaling Pathway.
Real-time qPCR results revealed that the downregulation of chicken miRNA gga-let-7d in the intestinal mucosal layer of Necrotic enteritis induced Fayoumi chicken line M15.2 was associated with the upregulation of its top-ranking target gene IGF2BP3.
Title: Distribution and differential expression of microRNAs in the intestinal mucosal layer of necrotic enteritis induced Fayoumi chickens.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor 2 mRNA-binding protein 3

Names: IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; VICKZ family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006359.1 → NP_001006359.1 insulin-like growth factor 2 mRNA-binding protein 3

See identical proteins and their annotated locations for NP_001006359.1

Status: PROVISIONAL

Source sequence(s)

AJ719686

UniProtKB/Swiss-Prot

Q5ZLP8

UniProtKB/TrEMBL

A0A8V0X5N3

Related

ENSGALP00010001853.1, ENSGALT00010003410.1

Conserved Domains (3) summary

cd12627
Location:1 → 77

RRM1_IGF2BP3; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cd12630
Location:81 → 156

RRM2_IGF2BP3; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cl00098
Location:276 → 370

KH-I; K homology (KH) RNA-binding domain, type I

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

31057514..31164938 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015281444.4 → XP_015136930.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

UniProtKB/Swiss-Prot

Q5ZLP8

UniProtKB/TrEMBL

A0A8V0X5N3

Related

ENSGALP00010001856.1, ENSGALT00010003413.1

Conserved Domains (3) summary

cd12627
Location:1 → 77

RRM1_IGF2BP3; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cd12630
Location:81 → 156

RRM2_IGF2BP3; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cl00098
Location:276 → 370

KH-I; K homology (KH) RNA-binding domain, type I
XM_025147195.3 → XP_025002963.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

UniProtKB/Swiss-Prot

Q5ZLP8

UniProtKB/TrEMBL

A0A8V0X5N3

Related

ENSGALP00010001858.1, ENSGALT00010003415.1

Conserved Domains (3) summary

cd12627
Location:1 → 77

RRM1_IGF2BP3; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cd12630
Location:81 → 156

RRM2_IGF2BP3; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cl00098
Location:276 → 370

KH-I; K homology (KH) RNA-binding domain, type I
XM_025147196.3 → XP_025002964.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X2

UniProtKB/TrEMBL

A0A8V0X5N3

Conserved Domains (4) summary

cd00105
Location:280 → 345

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12627
Location:1 → 77

RRM1_IGF2BP3; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cd12630
Location:81 → 156

RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

pfam00013
Location:367 → 431

KH_1; KH domain
XM_046922845.1 → XP_046778801.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

31103377..31210878 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046911132.1 → XP_046767088.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

UniProtKB/Swiss-Prot

Q5ZLP8
XM_046911133.1 → XP_046767089.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

UniProtKB/Swiss-Prot

Q5ZLP8
XM_046911134.1 → XP_046767090.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X2
XM_046911135.1 → XP_046767091.1 insulin-like growth factor 2 mRNA-binding protein 3 isoform X3