ENHO energy homeostasis associated [Homo sapiens (human)] - Gene

Summary

Official Symbol: ENHOprovided by HGNC
Official Full Name: energy homeostasis associatedprovided by HGNC
Primary source: HGNC:HGNC:24838
See related: Ensembl:ENSG00000168913 MIM:618556; AllianceGenome:HGNC:24838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UNQ470; C9orf165
Summary: Predicted to enable hormone activity. Predicted to be involved in positive regulation of Notch signaling pathway. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in brain (RPKM 43.8), testis (RPKM 5.1) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 9p13.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (34521043..34522990, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (34539581..34541528, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (34521041..34522988, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Development and validation of a new diagnostic prediction model of ENHO and NOX4 for early diagnosis of systemic sclerosis.
Title: Development and validation of a new diagnostic prediction model of ENHO and NOX4 for early diagnosis of systemic sclerosis.
Adropin attenuates pancreatitis-associated lung injury through PPARgamma phosphorylation-related macrophage polarization.
Title: Adropin attenuates pancreatitis‑associated lung injury through PPARγ phosphorylation‑related macrophage polarization.
Protective roles of adropin in neurological disease.
Title: Protective roles of adropin in neurological disease.
ERalpha-Dependent Regulation of Adropin Predicts Sex Differences in Liver Homeostasis during High-Fat Diet.
Title: ERα-Dependent Regulation of Adropin Predicts Sex Differences in Liver Homeostasis during High-Fat Diet.
The Clinical Value of Serum Adropin Level in Early Detection of Diabetic Nephropathy.
Title: The Clinical Value of Serum Adropin Level in Early Detection of Diabetic Nephropathy.
Adropin Serum Levels in Patients with Primary Sjogren's Syndrome.
Title: Adropin Serum Levels in Patients with Primary Sjögren's Syndrome.
Adropin decreases endothelial monolayer permeability after cell-free hemoglobin exposure and reduces MCP-1-induced macrophage transmigration.
Title: Adropin decreases endothelial monolayer permeability after cell-free hemoglobin exposure and reduces MCP-1-induced macrophage transmigration.
Potential effects of adropin on systemic metabolic and hormonal abnormalities in polycystic ovary syndrome.
Title: Potential effects of adropin on systemic metabolic and hormonal abnormalities in polycystic ovary syndrome.
Association between adropin and coronary artery lesions in children with Kawasaki disease.
Title: Association between adropin and coronary artery lesions in children with Kawasaki disease.
Lower adropin expression is associated with oxidative stress and severity of nonalcoholic fatty liver disease.
Title: Lower adropin expression is associated with oxidative stress and severity of nonalcoholic fatty liver disease.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH104089 (e-PCR)
- UniSTS:98414

A008S42 (e-PCR)
- UniSTS:15535

SHGC-32160 (e-PCR)
- UniSTS:28881

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adropin

Names: GAAI470; energy homeostasis-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.