BOLA-DRA major histocompatibility complex, class II, DR alpha [Bos taurus (cattle)] - Gene

Summary

Gene symbol: BOLA-DRA
Gene description: major histocompatibility complex, class II, DR alpha
See related: BGD:BT10358; Ensembl:ENSBTAG00000010645
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human all
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Genomic context

Location:: chromosome: 23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (25838391..25843092, complement)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
Title: Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis.
Four unique SSCP patterns were detected among 384 cattle from New Zealand and sequence analysis revealed that these SSCP patterns represent 4 DRA alleles; and 3 single nucleotide polymorphisms were detected in exon 2
Title: Short communication: Identification of allelic variation at the bovine DRA locus by polymerase chain reaction-single strand conformational polymorphism.

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General gene information

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Markers

MARC_26692-26693:1034099311:3 (e-PCR)
- UniSTS:269056

BoLA-DRA (e-PCR)
- UniSTS:519094

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptide antigen assembly with MHC class II protein complex	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell activation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: major histocompatibility complex, class II, DR alpha

Names: BoLA-DR-alpha; MHC class II antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012677.1 → NP_001012695.1 major histocompatibility complex, class II, DR alpha precursor

See identical proteins and their annotated locations for NP_001012695.1

Status: PROVISIONAL

Source sequence(s)

BT021059

UniProtKB/TrEMBL

Q30309, Q3ZCL4, Q95111

Related

ENSBTAP00000014072.6, ENSBTAT00000014072.7

Conserved Domains (3) summary

cd05767
Location:110 → 203

IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00993
Location:29 → 105

MHC_II_alpha; Class II histocompatibility antigen, alpha domain

pfam16196
Location:201 → 252

C1-set_C; C1-set C-terminal domain