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    CASP18 caspase-18 [ Monodelphis domestica (gray short-tailed opossum) ]

    Gene ID: 100017025, updated on 8-May-2024

    Summary

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    Gene symbol
    CASP18
    Gene description
    caspase-18
    See related
    EnsemblRapid:ENSMODG00000053847 EnsemblRapid:ENSMODG00000069753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Monodelphis domestica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
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    Genomic context

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    See CASP18 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_05 current mMonDom1.pri (GCF_027887165.1) 8 NC_077234.1 (92303588..92356915, complement)
    103 previous assembly MonDom5 (GCF_000002295.2) 7 NC_008807.1 (171568707..171621680)

    Chromosome 8 - NC_077234.1Genomic Context describing neighboring genes Neighboring gene caspase-8-like Neighboring gene caspase-8 Neighboring gene tumor protein p53-inducible nuclear protein 1-like Neighboring gene caspase-10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire. Eckhart L, et al. Mol Biol Evol, 2008 May. PMID 18281271

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase-18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114360.1 → NP_001107832.1  caspase-18

      See identical proteins and their annotated locations for NP_001107832.1

      Status: PROVISIONAL

      Source sequence(s)
      EU165365
      UniProtKB/TrEMBL
      A9YDV7
      Related
      ENSMODP00000063354.1, ENSMODT00000089668.1
      Conserved Domains (3) summary
      cd00032
      Location:229 → 459
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:1 → 80
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cd08334
      Location:94 → 177
      DED_Caspase_8_10_r2; Death effector domain, repeat 2, of initator caspases 8 and 10

    RefSeqs of Annotated Genomes: GCF_027887165.1-RS_2023_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mMonDom1.pri

    Genomic

    1. NC_077234.1 Reference mMonDom1.pri

      Range
      92303588..92356915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007501503.3 → XP_007501565.1  caspase-18 isoform X1

      UniProtKB/TrEMBL
      K7E316
      Related
      ENSMODP00000060705.1, ENSMODT00000112256.1
      Conserved Domains (3) summary
      cd00032
      Location:229 → 459
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08334
      Location:94 → 177
      DED_Caspase_8_10_r2; Death effector domain, repeat 2, of initator caspases 8 and 10
      cl14633
      Location:1 → 80
      DD; Death Domain Superfamily of protein-protein interaction domains
    Nucleotide Protein
    Heading Accession and Version

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