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    Acsl Acyl-CoA synthetase long-chain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46068, updated on 10-May-2024

    Summary

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    Official Symbol
    Acslprovided by FlyBase
    Official Full Name
    Acyl-CoA synthetase long-chainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263120
    Locus tag
    Dmel_CG8732
    See related
    AllianceGenome:FB:FBgn0263120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    7447; ACS; acsl; ACSL1; ACSL3; ACSL3/4; anon-WO0172774.173; CG8732; dAcsl; dFAC; Dmel\CG8732; FACS; FCS; l(2)05847; l(2)44DEa; l(2)7447; l(2)k05304; l(2)SH0465; l(2)SH2 0465
    Summary
    Enables palmitoyl-CoA ligase activity. Involved in several processes, including axon guidance; organophosphate biosynthetic process; and positive regulation of sequestering of triglyceride. Located in axon; endoplasmic reticulum; and peroxisome. Is expressed in several structures, including adult head; adult heart; and fat body. Used to study non-syndromic X-linked intellectual disability and non-syndromic X-linked intellectual disability 63. Human ortholog(s) of this gene implicated in asthma; breast cancer; intellectual disability; non-syndromic X-linked intellectual disability 63; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3) and ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Acsl in Genome Data Viewer
    Location:
    44E1-44E2; 2-59 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8665813..8683022)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4553318..4570527)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44281 Neighboring gene patched Neighboring gene transfer RNA:Leucine-CAG 1-1 Neighboring gene Ubiquinol-cytochrome c reductase 11 kDa subunit-like Neighboring gene uncharacterized protein Neighboring gene Jonah 44E Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Integrated Transcriptomics and Lipidomics Analysis Reveals That Ergosterol Is Required for Host Defense Against Bacterial Infection in Drosophila. Deng Z, et al. Front Immunol, 2022. PMID 35874695, Free PMC Article
    2. Free fatty acid determination as a tool for modeling metabolic diseases in Drosophila. Sellin J, et al. J Insect Physiol, 2020 Oct. PMID 32730782
    3. Reticulon-like-1, the Drosophila orthologue of the hereditary spastic paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons. O'Sullivan NC, et al. Hum Mol Genet, 2012 Aug 1. PMID 22543973, Free PMC Article
    4. Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids. Huang Y, et al. J Cell Sci, 2016 Nov 1. PMID 27656110
    5. Listeria monocytogenes infection causes metabolic shifts in Drosophila melanogaster. Chambers MC, et al. PLoS One, 2012. PMID 23272066, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. novel insights into a critical and previously unappreciated role of Acsl in neurogenesis
      Title: Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation.
    2. Acsl inhibits neuromuscular junction growth.
      Title: Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids.
    3. our results reveal a novel mechanism whereby dAcsl facilitates Rab11-dependent receptor recycling and provide insights into the pathogenesis of ACSL4-related mental retardation
      Title: dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.
    4. propose that Acsl plays a role in embryonic segmentation by shifting the anteroposterior boundaries of gap genes Kni and Hb
      Title: Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation.
    5. this study demonstrated that dAcsl regulates axonal transport of synaptic vesicles and is required for synaptic development and function.
      Title: Drosophila Acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission.
    6. ACSL4 can substitute the functions of dAcsl(l(2)44DEa in organismal viability, lipid storage and the neural wiring in visual center.
      Title: Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables palmitoyl-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in long-chain fatty-acyl-CoA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylglycerol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sequestering of triglyceride IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA synthetase long-chain
    Names
    Acsl-PA
    Acsl-PB
    Acsl-PC
    Acsl-PD
    Acsl-PE
    Acsl-PF
    Acsl-PG
    Acsl-PH
    Acsl-PI
    Acsl-PJ
    Acyl-CoAsynthetase long-chain
    CG8732-PA
    CG8732-PB
    CG8732-PC
    CG8732-PD
    CG8732-PE
    CG8732-PF
    CG8732-PG
    CG8732-PH
    CG8732-PI
    CG8732-PJ
    Long-chain acyl-CoA synthetase
    fatty acyl CoA synthetase
    fatty acyl coenzyme A (CoA) synthetase
    fatty acyl-CoA synthetase
    lethal (2) 44DEa
    lethal (2) SH0465
    NP_001014507.1
    NP_001014508.1
    NP_001014509.1
    NP_001014510.1
    NP_001014511.1
    NP_001014512.1
    NP_001260810.1
    NP_652034.2
    NP_724695.1
    NP_724696.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8665813..8683022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014511.2 → NP_001014511.1  Acyl-CoA synthetase long-chain, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014511.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NS4, Q8T3L1, Q9V4W4
      Conserved Domains (2) summary
      cd05927
      Location:129 → 713
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:82 → 714
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    2. NM_170615.2 → NP_724695.1  Acyl-CoA synthetase long-chain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NS4, Q8T3L1, Q9V4W4
      Related
      FBpp0087779
      Conserved Domains (2) summary
      cd05927
      Location:129 → 713
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:82 → 714
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    3. NM_143777.3 → NP_652034.2  Acyl-CoA synthetase long-chain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652034.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NS4, Q8T3L1, Q9V4W4
      Related
      FBpp0087780
      Conserved Domains (2) summary
      cd05927
      Location:129 → 713
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:82 → 714
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    4. NM_001014512.2 → NP_001014512.1  Acyl-CoA synthetase long-chain, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014512.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7H2, Q86NS4
      Conserved Domains (2) summary
      cd05927
      Location:131 → 715
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:84 → 716
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    5. NM_001014510.2 → NP_001014510.1  Acyl-CoA synthetase long-chain, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7H3, Q86NS4
      Conserved Domains (2) summary
      cd05927
      Location:121 → 705
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:74 → 706
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    6. NM_001014508.2 → NP_001014508.1  Acyl-CoA synthetase long-chain, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NS4, Q8T3L1, Q9V4W4
      Conserved Domains (2) summary
      cd05927
      Location:129 → 713
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:82 → 714
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    7. NM_001014509.2 → NP_001014509.1  Acyl-CoA synthetase long-chain, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014509.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7H3, Q86NS4
      Conserved Domains (2) summary
      cd05927
      Location:121 → 705
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:74 → 706
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    8. NM_001273881.1 → NP_001260810.1  Acyl-CoA synthetase long-chain, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260810.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFE4, Q86NS4
      Conserved Domains (2) summary
      cd05927
      Location:142 → 726
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:95 → 727
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    9. NM_170616.2 → NP_724696.1  Acyl-CoA synthetase long-chain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724696.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7H3, Q86NS4
      Related
      FBpp0087781
      Conserved Domains (2) summary
      cd05927
      Location:121 → 705
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:74 → 706
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    10. NM_001014507.2 → NP_001014507.1  Acyl-CoA synthetase long-chain, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7H3, Q86NS4
      Conserved Domains (2) summary
      cd05927
      Location:121 → 705
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:74 → 706
      PLN02387; long-chain-fatty-acid-CoA ligase family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFE4 A0A0B4KFE4
    A1Z7H2 A1Z7H2
    A1Z7H3 A1Z7H3
    Q8T3L1 Q8T3L1
    Q960I0 Q960I0

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