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    LOC100161478 protein smoothened [ Acyrthosiphon pisum (pea aphid) ]

    Gene ID: 100161478, updated on 7-Dec-2023

    Summary

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    Gene symbol
    LOC100161478
    Gene description
    protein smoothened
    See related
    APHIDBASE:ACYPI002697; EnsemblRapid:LOC100161478
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Acyrthosiphon pisum
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha; Aphidoidea; Aphididae; Macrosiphini; Acyrthosiphon
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    Genomic context

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    Location:
    chromosome: A2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current pea_aphid_22Mar2018_4r6ur (GCF_005508785.1) A2 NC_042495.1 (75807256..75812875, complement)
    102 previous assembly Acyr_2.0 (GCF_000142985.2) Unplaced Scaffold NW_003384242.1 (4361..9781)

    Chromosome A2 - NC_042495.1Genomic Context describing neighboring genes Neighboring gene protein phosphatases pp1 regulatory subunit-like Neighboring gene U3 small nucleolar RNA-associated protein 14 homolog C Neighboring gene 26S proteasome non-ATPase regulatory subunit 6 Neighboring gene TP53-regulating kinase Neighboring gene uncharacterized protein ZK1073.1 Neighboring gene ATP-dependent RNA helicase DRS1 Neighboring gene uncharacterized LOC107882565

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables patched binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in commissural neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein smoothened

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Acyrthosiphon pisum Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference pea_aphid_22Mar2018_4r6ur Primary Assembly

    Genomic

    1. NC_042495.1 Reference pea_aphid_22Mar2018_4r6ur Primary Assembly

      Range
      75807256..75812875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008188302.3 → XP_008186524.1  protein smoothened isoform X3

      UniProtKB/TrEMBL
      A0A8R2B8F8
      Related
      XP_008186524.1, XM_008188302.3
      Conserved Domains (3) summary
      cd07451
      Location:43 → 176
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      cd14964
      Location:210 → 235
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:201 → 522
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_008188301.3 → XP_008186523.1  protein smoothened isoform X2

      UniProtKB/TrEMBL
      A0A8R2B8Q5
      Related
      XP_008186523.1, XM_008188301.3
      Conserved Domains (3) summary
      cd07451
      Location:43 → 176
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      cd14964
      Location:210 → 235
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:201 → 521
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_001948992.5 → XP_001949027.1  protein smoothened isoform X1

      UniProtKB/TrEMBL
      A0A8R1W5X2
      Related
      XP_001949027.1, XM_001948992.5
      Conserved Domains (3) summary
      cd07451
      Location:43 → 176
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      cd14964
      Location:210 → 235
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:201 → 522
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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