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    Idh3g isocitrate dehydrogenase 3 (NAD+), gamma [ Mus musculus (house mouse) ]

    Gene ID: 15929, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Idh3gprovided by MGI
    Official Full Name
    isocitrate dehydrogenase 3 (NAD+), gammaprovided by MGI
    Primary source
    MGI:MGI:1099463
    See related
    Ensembl:ENSMUSG00000002010 AllianceGenome:MGI:1099463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable isocitrate dehydrogenase (NAD+) activity and magnesium ion binding activity. Predicted to be involved in several processes, including NADH metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 350.1), kidney adult (RPKM 236.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A7.3; X 37.41 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72822569..72830471, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73778963..73786897, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene plexin B3 Neighboring gene serine/arginine-rich protein specific kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E11049 Neighboring gene signal sequence receptor, delta Neighboring gene STARR-seq mESC enhancer starr_47355 Neighboring gene PDZ domain containing 4 Neighboring gene predicted gene, 23615

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The β and γ subunits play distinct functional roles in the α(2)βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase. Ma T, et al. Sci Rep, 2017 Jan 31. PMID 28139779, Free PMC Article
    2. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. Brenner V, et al. Genomics, 1997 Aug 15. PMID 9286695
    3. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, et al. J Biol Chem, 2003 Dec 26. PMID 14555658
    4. A major X-linked locus affects kidney function in mice. Leduc MS, et al. Mol Genet Genomics, 2012 Dec. PMID 23011808, Free PMC Article
    5. At Term, XmO and XpO Mouse Placentas Show Differences in Glucose Metabolism in the Trophectoderm-Derived Outer Zone. He N, et al. Front Cell Dev Biol, 2017. PMID 28680878, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
      Title: BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isocitrate dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isocitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isocitrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of isocitrate dehydrogenase complex (NAD+) ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
    Names
    NAD(+)-specific ICDH subunit gamma
    isocitric dehydrogenase subunit gamma
    NP_001343285.1
    NP_001398440.1
    NP_001398442.1
    NP_001398445.1
    NP_001398446.1
    NP_001398447.1
    NP_001398448.1
    NP_032349.1
    XP_017173881.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356356.2 → NP_001343285.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL672094
      UniProtKB/TrEMBL
      Q3TKM5, Q684I8
      Conserved Domains (1) summary
      TIGR00175
      Location:48 → 379
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    2. NM_001411511.1 → NP_001398440.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672094

    3. NM_001411513.1 → NP_001398442.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672094

    4. NM_001411516.1 → NP_001398445.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL672094

    5. NM_001411517.1 → NP_001398446.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL672094

    6. NM_001411518.1 → NP_001398447.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL672094

    7. NM_001411519.1 → NP_001398448.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL672094

    8. NM_008323.2 → NP_032349.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_032349.1

      Status: VALIDATED

      Source sequence(s)
      AL672094
      Consensus CDS
      CCDS30212.1
      UniProtKB/Swiss-Prot
      P70404
      UniProtKB/TrEMBL
      Q3TGZ3, Q684I8
      Related
      ENSMUSP00000056502.9, ENSMUST00000052761.9
      Conserved Domains (1) summary
      TIGR00175
      Location:52 → 383
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    RNA

    1. NR_177282.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672094

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72822569..72830471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318392.2 → XP_017173881.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q684I8
      Conserved Domains (1) summary
      TIGR00175
      Location:1 → 325
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70404.1 GenPept UniProtKB/Swiss-Prot:P70404

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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