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    aire autoimmune regulator [ Danio rerio (zebrafish) ]

    Gene ID: 100007662, updated on 5-Jan-2022

    Summary

    Official Symbol
    aireprovided by ZNC
    Official Full Name
    autoimmune regulatorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071008-4
    See related
    Ensembl:ENSDARG00000056784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-261l2.5
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in several processes, including immune system development; positive regulation of transcription by RNA polymerase II; and regulation of thymocyte migration. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator). [provided by Alliance of Genome Resources, Nov 2021]
    Orthologs
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    Genomic context

    See aire in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (22808544..22826253)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (23153224..23170602)
    103 previous assembly Zv9 (GCF_000002035.4) 2 NC_007113.5 (22266590..22283797)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene espin like b Neighboring gene RAB6B, member RAS oncogene family b Neighboring gene angiomotin like 2b Neighboring gene myosin VIIBb Neighboring gene uncharacterized LOC103910043

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in central tolerance induction to self antigen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within humoral immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative thymic T cell selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peripheral T cell tolerance induction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of thymocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in thymus epithelium morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110014.1NP_001103484.1  autoimmune regulator

      See identical proteins and their annotated locations for NP_001103484.1

      Status: PROVISIONAL

      Source sequence(s)
      EU042187
      UniProtKB/TrEMBL
      A8HG42
      Related
      ENSDARP00000114968.1, ENSDART00000133250.3
      Conserved Domains (4) summary
      cd15539
      Location:294336
      PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)
      cd15540
      Location:402439
      PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)
      pfam03172
      Location:11107
      Sp100; Sp100 domain
      cl02536
      Location:197232
      SAND; SAND domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      22808544..22826253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009298506.3XP_009296781.1  autoimmune regulator isoform X1

      Conserved Domains (4) summary
      cd15539
      Location:273315
      PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)
      cd15540
      Location:381418
      PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)
      pfam03172
      Location:11107
      Sp100; Sp100 domain
      cl02536
      Location:197232
      SAND; SAND domain
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