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    myh14 myosin, heavy chain 14, non-muscle [ Danio rerio (zebrafish) ]

    Gene ID: 563011, updated on 11-Apr-2024

    Summary

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    Official Symbol
    myh14provided by ZNC
    Official Full Name
    myosin, heavy chain 14, non-muscleprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100921-1
    See related
    Ensembl:ENSDARG00000073732 AllianceGenome:ZFIN:ZDB-GENE-100921-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-120k19.2; si:ch211-120k19.3
    Summary
    Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Predicted to be part of myosin complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See myh14 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (16849250..16941144)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (16941297..17034305)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene urotensin-2 receptor 3 Neighboring gene potassium inwardly rectifying channel subfamily J member 14 Neighboring gene uncharacterized LOC110437979 Neighboring gene si:ch211-120k19.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin-14; myosin-10
    XP_005157988.1
    XP_005157991.1
    XP_009290471.1
    XP_009290472.1
    XP_009290473.1
    XP_009290474.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      16849250..16941144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292196.3 → XP_009290471.1  myosin-10 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AQG4
      Conserved Domains (8) summary
      cl22853
      Location:106 → 836
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:94 → 836
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:913 → 1993
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:41 → 77
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam10212
      Location:1811 → 2011
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
      cd16269
      Location:1232 → 1243
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1067 → 1263
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1552 → 1649
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_009292198.3 → XP_009290473.1  myosin-10 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B1K3
      Conserved Domains (7) summary
      cl22853
      Location:106 → 836
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:94 → 836
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:913 → 1993
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:41 → 77
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:1232 → 1243
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1067 → 1263
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1552 → 1649
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. XM_005157931.4 → XP_005157988.1  myosin-10 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B482
      Conserved Domains (8) summary
      cl22853
      Location:106 → 831
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:94 → 831
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:908 → 1988
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:41 → 77
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam10212
      Location:1806 → 2006
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
      cd16269
      Location:1227 → 1238
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1062 → 1258
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1547 → 1644
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. XM_009292197.3 → XP_009290472.1  myosin-10 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AHY4
      Conserved Domains (8) summary
      cl22853
      Location:106 → 832
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:94 → 832
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:909 → 1989
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:41 → 77
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam10212
      Location:1807 → 2007
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
      cd16269
      Location:1228 → 1239
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1063 → 1259
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1548 → 1645
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. XM_009292199.3 → XP_009290474.1  myosin-10 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AJ07
      Conserved Domains (7) summary
      cl22853
      Location:106 → 820
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:94 → 820
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:897 → 1977
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:41 → 77
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:1216 → 1227
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1051 → 1247
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1536 → 1633
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    6. XM_005157934.4 → XP_005157991.1  myosin-10 isoform X6

      UniProtKB/TrEMBL
      A0A8M2B4A6
      Related
      ENSDARP00000047408.8, ENSDART00000047409.8
      Conserved Domains (7) summary
      cl22853
      Location:106 → 807
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:94 → 807
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:884 → 1964
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:41 → 77
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:1203 → 1214
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1038 → 1234
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1523 → 1620
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version

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