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    HMF1 putative isoleucine biosynthesis protein HMF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856785, updated on 13-Apr-2024

    Summary

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    Gene symbol
    HMF1
    Gene description
    putative isoleucine biosynthesis protein HMF1
    Primary source
    SGD:S000000859
    Locus tag
    YER057C
    See related
    AllianceGenome:SGD:S000000859
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HIG1
    Summary
    Predicted to enable deaminase activity. Predicted to be involved in organonitrogen compound catabolic process. Located in cytosol; mitochondrial intermembrane space; and nucleus. Orthologous to human RIDA (reactive intermediate imine deaminase A homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (270737..271126, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene purine-cytosine permease Neighboring gene ribosomal 60S subunit protein L34A Neighboring gene Pet117p Neighboring gene Pcl6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family. Parsons L, et al. Biochemistry, 2003 Jan 14. PMID 12515541
    2. X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1). Deaconescu AM, et al. Proteins, 2002 Aug 1. PMID 12112709
    3. Bacterial proteins predisposed for targeting to mitochondria. Lucattini R, et al. Mol Biol Evol, 2004 Apr. PMID 14739247
    4. A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae. Kim JM, et al. Genes Cells, 2001 Jun. PMID 11442631
    5. Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome. Oxelmark E, et al. Mol Cell Biol, 2000 Oct. PMID 11003673, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in organonitrogen compound catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative isoleucine biosynthesis protein HMF1
    NP_010978.3
    • Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      270737..271126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178948.3 → NP_010978.3  TPA: putative isoleucine biosynthesis protein HMF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010978.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLW1, P40037
      UniProtKB/TrEMBL
      A0A6A5PYE4, A6ZR10, B3LS72, C7GWJ0, C8Z763, G2WCU4, N1PA41
      Conserved Domains (1) summary
      TIGR00004
      Location:24 → 127
      TIGR00004; reactive intermediate/imine deaminase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40037.1

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