U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Apoc2l apolipoprotein C2 like [ Mus musculus (house mouse) ]

    Gene ID: 105886299, updated on 8-Feb-2024

    Summary

    Official Symbol
    Apoc2lprovided by MGI
    Official Full Name
    apolipoprotein C2 likeprovided by MGI
    Primary source
    MGI:MGI:5753381
    See related
    Ensembl:ENSMUSG00000109350 AllianceGenome:MGI:5753381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm44805; Apoc4-apoc2
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring apolipoprotein C-IV (Apoc4) and apolipoprotein C-II (Apoc2) genes on chromosome 7. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene (Apoc2). [provided by RefSeq, Jun 2015]
    Expression
    Biased expression in duodenum adult (RPKM 646.2), liver E18 (RPKM 538.9) and 6 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Apoc2l in Genome Data Viewer
    Location:
    7 A3; 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19405504..19415385, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19671579..19681460, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene avian reticuloendotheliosis viral (v-rel) oncogene related B Neighboring gene STARR-positive B cell enhancer ABC_E1720 Neighboring gene cleft lip and palate associated transmembrane protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E4901 Neighboring gene apolipoprotein C2 Neighboring gene STARR-seq mESC enhancer starr_18215 Neighboring gene apolipoprotein C-IV Neighboring gene apolipoprotein C-I Neighboring gene apolipoprotein E

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    General gene information

    Readthrough Apoc2l

    Included genes: Apoc4, Apoc2

    Clone Names

    • MGC117889

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipoprotein lipase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chylomicron remnant clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in high-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoprotein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of very-low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of chylomicron ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of intermediate-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spherical high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apolipoprotein C-II
    Names
    Apoc4-Apoc2 readthrough

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309799.1NP_001296728.1  apolipoprotein C-II precursor

      See identical proteins and their annotated locations for NP_001296728.1

      Status: VALIDATED

      Source sequence(s)
      AC149282
      UniProtKB/Swiss-Prot
      Q05020
      UniProtKB/TrEMBL
      D3YXE8, Q3UJG0
      Related
      ENSMUSP00000114512.2, ENSMUST00000150569.9
      Conserved Domains (1) summary
      pfam05355
      Location:2196
      Apo-CII; Apolipoprotein C-II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19405504..19415385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)