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    MS4A1 membrane spanning 4-domains A1 [ Canis lupus familiaris (dog) ]

    Gene ID: 485430, updated on 22-Jan-2024

    Summary

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    Official Symbol
    MS4A1provided by VGNC
    Official Full Name
    membrane spanning 4-domains A1provided by VGNC
    Primary source
    VGNC:VGNC:52268
    See related
    Ensembl:ENSCAFG00845020720
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    CD20
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    Genomic context

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    Location:
    chromosome: 21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (51895623..51907069)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (50162433..50173865)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (51664248..51675690)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (50941639..50953065)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (51040140..51051579)

    Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A14 Neighboring gene membrane spanning 4-domains A5 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102156346 Neighboring gene microRNA mir-8813-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Canine CD20 gene. Kano R, et al. Vet Immunol Immunopathol, 2005 Dec 15. PMID 16061290
    2. Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20. Weiskopf K, et al. Cancer Immunol Res, 2016 Dec. PMID 27856424, Free PMC Article
    3. Immunohistochemical detection of multiple myeloma 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine plasmacytoma: comparison with CD79a and CD20. Ramos-Vara JA, et al. Vet Pathol, 2007 Nov. PMID 18039900

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings indicate that CD47 blockade alone and in combination with anti-CD20 may be an effective strategy for treating canine lymphoma
      Title: Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20.
    2. This study examined the immunoreactivity of a monoclonal antibody to MUM1/IRF4 and compared it with expression of CD79a and CD20 in 109 plasmacytomas in 107 dogs.
      Title: Immunohistochemical detection of multiple myeloma 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine plasmacytoma: comparison with CD79a and CD20.
    3. Canine CD20 gene was cloned and sequenced, and the expression of CD20 mRNA was investigated in canine peripheral blood mononuclear cells (PBMCs), and lymph nodes from healthy dogs, and canine lymphoma cells.
      Title: Canine CD20 gene.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B-lymphocyte antigen CD20
    Names
    membrane-spanning 4-domains, subfamily A, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048028.1 → NP_001041493.1  B-lymphocyte antigen CD20

      See identical proteins and their annotated locations for NP_001041493.1

      Status: PROVISIONAL

      Source sequence(s)
      AB210085
      UniProtKB/Swiss-Prot
      Q3C2E2
      UniProtKB/TrEMBL
      A0A8C0QD94
      Related
      ENSCAFP00845028628.1, ENSCAFT00845036583.1
      Conserved Domains (1) summary
      pfam04103
      Location:51 → 216
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051825.1 Reference ROS_Cfam_1.0

      Range
      51895623..51907069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038429506.1 → XP_038285434.1  B-lymphocyte antigen CD20 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JGQ9, A0A8C0QD94
      Conserved Domains (1) summary
      pfam04103
      Location:51 → 216
      CD20; CD20-like family

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049281.1 Alternate UMICH_Zoey_3.1

      Range
      50941639..50953065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

      Range
      51040140..51051579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

      Range
      51664248..51675690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      50162433..50173865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3C2E2.1 GenPept UniProtKB/Swiss-Prot:Q3C2E2

    Gene LinkOut

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