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    ORF67 envelope glycoprotein I [ Human alphaherpesvirus 3 (Varicella-zoster virus) ]

    Gene ID: 1487689, updated on 18-Aug-2023

    Summary

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    Gene symbol
    ORF67
    Gene description
    envelope glycoprotein I
    Locus tag
    HHV3_gp68
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human alphaherpesvirus 3 (strain: Dumas, acronym: HHV-3, acronym: VZV, nat-host: Homo sapiens)
    Lineage
    Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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    Genomic context

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    Sequence:
    NC_001348.1 (114496..115592)

    NC_001348.1Genomic Context describing neighboring genes Neighboring gene membrane protein US9 Neighboring gene serine/threonine protein kinase US3 Neighboring gene envelope glycoprotein E Neighboring gene virion protein US10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001348.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Varicella-zoster virus glycoprotein I is essential for spread in dorsal root ganglia and facilitates axonal localization of structural virion components in neuronal cultures. Christensen J, et al. J Virol, 2013 Dec. PMID 24109230, Free PMC Article
    2. Mutagenesis of varicella-zoster virus glycoprotein I (gI) identifies a cysteine residue critical for gE/gI heterodimer formation, gI structure, and virulence in skin cells. Oliver SL, et al. J Virol, 2011 May. PMID 21345964, Free PMC Article
    3. Deletion of the first cysteine-rich region of the varicella-zoster virus glycoprotein E ectodomain abolishes the gE and gI interaction and differentially affects cell-cell spread and viral entry. Berarducci B, et al. J Virol, 2009 Jan. PMID 18945783, Free PMC Article
    4. Varicella-zoster virus Fc receptor component gI is phosphorylated on its endodomain by a cyclin-dependent kinase. Ye M, et al. J Virol, 1999 Feb. PMID 9882337, Free PMC Article
    5. The complete DNA sequence of varicella-zoster virus. Davison AJ, et al. J Gen Virol, 1986 Sep. PMID 3018124

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gI is essential for the cell-to-cell spread of virus during productive replication in neuronal cells.
      Title: Varicella-zoster virus glycoprotein I is essential for spread in dorsal root ganglia and facilitates axonal localization of structural virion components in neuronal cultures.
    2. Substitution of four cysteine residues highly conserved in the Alphaherpesvirinae established that C95 is required for gE/gI heterodimer formation.
      Title: Mutagenesis of varicella-zoster virus glycoprotein I (gI) identifies a cysteine residue critical for gE/gI heterodimer formation, gI structure, and virulence in skin cells.
    3. Blocking gE binding to gI resulted in severe impairment of VZV infection of human skin xenografts in SCIDhu mice in vivo, documenting the importance of cell fusion mediated by this complex for VZV virulence in skin.
      Title: Deletion of the first cysteine-rich region of the varicella-zoster virus glycoprotein E ectodomain abolishes the gE and gI interaction and differentially affects cell-cell spread and viral entry.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    regulatory

    • Loc: 115587-115592 regulatory_class = polyA_signal_sequence

    General protein information

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    Preferred Names
    envelope glycoprotein I
    NP_040189.1
    • gD family

    VOG classification

    Description:

    • VOGd0144 [S] Virion membrane glycoprotein I
    • Structural Proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001348.1 Reference assembly

      Range
      114496..115592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040189.1 envelope glycoprotein I [Human alphaherpesvirus 3]

      See identical proteins and their annotated locations for NP_040189.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P09258, Q77NN4
      UniProtKB/TrEMBL
      A0A1B1JGF4, A0A3G2KS43, G9IWV9, G9IY67, Q775H9, Q77JF6, Q98VN1
      Conserved Domains (1) summary
      PHA03290
      Location:1 → 354
      PHA03290; envelope glycoprotein I; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    CAA27950.1

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