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    vpu Vpu [ Human immunodeficiency virus 1 ]

    Gene ID: 155945, updated on 6-Oct-2023

    Summary

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    Gene symbol
    vpu
    Gene description
    Vpu
    Locus tag
    HIV1gp7
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Human immunodeficiency virus 1
    Lineage
    Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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    Genomic context

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    Sequence:
    NC_001802.1 (5608..5856)

    NC_001802.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol Neighboring gene Pr55(Gag) Neighboring gene Vif Neighboring gene Vpr Neighboring gene Tat Neighboring gene Rev Neighboring gene Envelope surface glycoprotein gp160, precursor Neighboring gene Asp Neighboring gene Nef

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001802.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Novel Vpu Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral Release. Lu Y, et al. J Virol, 2023 Apr 27. PMID 36971578, Free PMC Article
    2. Insights into the oligomeric structure of the HIV-1 Vpu protein. Majeed S, et al. J Struct Biol, 2023 Mar. PMID 36796461, Free PMC Article
    3. Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis. Khan N, et al. Viruses, 2021 Jul 27. PMID 34452331, Free PMC Article
    4. Conditional activation of an HIV-1 protease attenuated mutant by a leucine zipper dimerization motif. Yu FH, et al. Virus Res, 2021 Apr 2. PMID 33316353
    5. Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu. Jain P, et al. Cell Rep, 2018 Feb 27. PMID 29490283, Free PMC Article

    See all (385) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association.
      Title: HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association.
    2. A Novel Vpu Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral Release.
      Title: A Novel Vpu Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral Release.
    3. Insights into the oligomeric structure of the HIV-1 Vpu protein.
      Title: Insights into the oligomeric structure of the HIV-1 Vpu protein.
    4. Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.
      Title: Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.
    5. Conditional activation of an HIV-1 protease attenuated mutant by a leucine zipper dimerization motif.
      Title: Conditional activation of an HIV-1 protease attenuated mutant by a leucine zipper dimerization motif.
    6. Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis.
      Title: Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis.
    7. HIV-1 Vpu Promotes Phagocytosis of Infected CD4(+) T Cells by Macrophages through Downregulation of CD47.
      Title: HIV-1 Vpu Promotes Phagocytosis of Infected CD4(+) T Cells by Macrophages through Downregulation of CD47.
    8. The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release.
      Title: The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release.
    9. Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes.
      Title: Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes.
    10. HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4(+) T Cells.
      Title: HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4(+) T Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (162)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    fatty acid CoA ligase Acsl3 ACSL3 interacts with PubMed
    AP-1 complex subunit beta-1 isoform a AP1B1 binds PubMed
    AP-1 complex subunit gamma-1 isoform b AP1G1 interacts with PubMed
    AP1G1 interacts with PubMed
    AP-1 complex subunit mu-1 isoform 2 AP1M1 interacts with PubMed
    AP1M1 binds PubMed
    AP-1 complex subunit sigma-1A AP1S1 interacts with PubMed
    AP1S1 binds PubMed
    AP-2 complex subunit alpha-1 isoform 1 AP2A1 interacts with PubMed
    AP-2 complex subunit mu isoform a AP2M1 interacts with PubMed
    AP2M1 interacts with PubMed
    DNA dC->dU-editing enzyme APOBEC-3F isoform a APOBEC3F inhibits PubMed
    DNA dC->dU-editing enzyme APOBEC-3G isoform 1 APOBEC3G inhibits PubMed
    apolipoprotein L1 isoform a precursor APOL1 downregulated by PubMed
    brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform 1 ARFGEF1 interacts with PubMed
    brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1 ARFGEF2 interacts with PubMed
    ATPase family AAA domain-containing protein 3A isoform 1 ATAD3A interacts with PubMed
    ATPase family AAA domain-containing protein 3B isoform AAA-TOB3l ATAD3B interacts with PubMed
    cyclic AMP-dependent transcription factor ATF-4 ATF4 stabilizes PubMed
    plasma membrane calcium-transporting ATPase 1 isoform 1b ATP2B1 interacts with PubMed
    ATP synthase subunit beta, mitochondrial precursor ATP5F1B interacts with PubMed
    ATP synthase subunit delta, mitochondrial precursor ATP5F1D interacts with PubMed
    ATP synthase F(0) complex subunit B1, mitochondrial precursor ATP5PB interacts with PubMed
    ATP synthase subunit d, mitochondrial isoform a ATP5PD interacts with PubMed
    ATP synthase-coupling factor 6, mitochondrial isoform a precursor ATP5PF interacts with PubMed
    ATP synthase subunit O, mitochondrial precursor ATP5PO interacts with PubMed
    ataxin-10 isoform 1 ATXN10 interacts with PubMed
    aurora kinase A isoform 1 AURKA binds PubMed
    beta-2-microglobulin precursor B2M downregulates PubMed
    apoptosis regulator BAX isoform beta BAX upregulates PubMed
    bcl-2-related protein A1 isoform 1 BCL2A1 downregulates PubMed
    bcl-2-like protein 1 isoform Bcl-X(L) BCL2L1 downregulates PubMed
    bone marrow stromal antigen 2 precursor BST2 increases PubMed
    BST2 downregulates PubMed
    BST2 inhibits PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 counteracts PubMed
    BST2 downregulates PubMed
    BST2 requires PubMed
    BST2 relocalizes PubMed
    BST2 requires PubMed
    BST2 antagonizes PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 co-localizes with PubMed
    BST2 disrupts PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 stabilizes PubMed
    BST2 interacts with PubMed
    BST2 inhibits PubMed
    BST2 inhibits PubMed
    BST2 inhibited by PubMed
    BST2 downregulates PubMed
    BST2 degrades PubMed
    BST2 downregulates PubMed
    BST2 inhibits PubMed
    BST2 relocalizes PubMed
    BST2 downregulates PubMed
    BST2 inhibits PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 relocalizes PubMed
    BST2 downregulates PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 binds PubMed
    BST2 inhibits PubMed
    BST2 interacts with PubMed
    BST2 inhibited by PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 inhibits PubMed
    BST2 inhibits PubMed
    BST2 interacts with PubMed
    BST2 relocalizes PubMed
    BST2 inhibits PubMed
    BST2 downregulates PubMed
    BST2 inhibits PubMed
    BST2 downregulates PubMed
    BST2 interacts with PubMed
    BST2 interacts with PubMed
    BST2 interacts with PubMed
    BST2 interacts with PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 inhibits PubMed
    BST2 inhibits PubMed
    BST2 downregulates PubMed
    BST2 degrades PubMed
    BST2 degrades PubMed
    BST2 induces ubiquitination of PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 inhibits PubMed
    BST2 relocalizes PubMed
    BST2 induces ubiquitination of PubMed
    BST2 interacts with PubMed
    BST2 inhibits PubMed
    BST2 inhibits PubMed
    BST2 interacts with PubMed
    BST2 modulates PubMed
    BST2 inhibits PubMed
    BST2 binds PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 inhibits PubMed
    BST2 downregulates PubMed
    BST2 interacts with PubMed
    BST2 inhibits PubMed
    BST2 interacts with PubMed
    BST2 modulates PubMed
    BST2 degrades PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 interacts with PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 downregulates PubMed
    BST2 disrupts PubMed
    BST2 binds PubMed
    BST2 downregulates PubMed
    F-box/WD repeat-containing protein 1A isoform 2 BTRC requires PubMed
    BTRC interacts with PubMed
    BTRC interacts with PubMed
    BTRC recruits PubMed
    BTRC binds PubMed
    BTRC binds PubMed
    BTRC binds PubMed
    BTRC interacts with PubMed
    BTRC interacts with PubMed
    BTRC interacts with PubMed
    BTRC competes with PubMed
    BTRC interacts with PubMed
    BTRC interacts with PubMed
    BTRC inhibits PubMed
    BTRC interacts with PubMed
    BTRC interacts with PubMed
    BTRC inhibits PubMed
    caspase-3 isoform a preproprotein CASP3 cooperates with PubMed
    CASP3 activates PubMed
    caspase-8 isoform 1 precursor CASP8 cooperates with PubMed
    eotaxin precursor CCL11 downregulates PubMed
    C-C motif chemokine 19 precursor CCL19 inhibits PubMed
    CCL19 inhibits PubMed
    C-C chemokine receptor type 7 isoform a precursor CCR7 downregulates PubMed
    CCR7 downregulates PubMed
    CCR7 downregulates PubMed
    CCR7 downregulates PubMed
    CCR7 co-localizes with PubMed
    CD109 antigen isoform 1 preproprotein CD109 downregulates PubMed
    sialomucin core protein 24 isoform 1 precursor CD164 downregulates PubMed
    T-cell surface glycoprotein CD1c precursor CD1C downregulates PubMed
    antigen-presenting glycoprotein CD1d isoform 1 precursor CD1D downregulates PubMed
    CD1D downregulates PubMed
    CD1D downregulates PubMed
    CD1D downregulates PubMed
    CD1D inhibits PubMed
    T-cell surface glycoprotein CD3 zeta chain isoform 1 precursor CD247 interacts with PubMed
    CD27 antigen precursor CD27 downregulates PubMed
    leukocyte antigen CD37 isoform A CD37 relocalizes PubMed
    CD37 downregulates PubMed
    T-cell surface glycoprotein CD3 delta chain isoform A precursor CD3D interacts with PubMed
    T-cell surface glycoprotein CD3 epsilon chain precursor CD3E antagonizes PubMed
    CD3E interacts with PubMed
    T-cell surface glycoprotein CD3 gamma chain precursor CD3G interacts with PubMed
    T-cell surface glycoprotein CD4 isoform 1 precursor CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 degrades PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 depends on PubMed
    CD4 interacts with PubMed
    CD4 downregulates PubMed
    CD4 degrades PubMed
    CD4 interacts with PubMed
    CD4 relocalizes PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 interacts with PubMed
    CD4 inhibited by PubMed
    CD4 regulates PubMed
    CD4 binds PubMed
    CD4 interacts with PubMed
    CD4 interacts with PubMed
    CD4 induces accumulation of PubMed
    CD4 interacts with PubMed
    CD4 downregulates PubMed
    CD4 binds PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 downregulates PubMed
    CD4 degrades PubMed
    tumor necrosis factor receptor superfamily member 5 isoform 1 precursor CD40 upregulates PubMed
    CD48 antigen isoform 1 precursor CD48 downregulates PubMed
    leukocyte surface antigen CD53 isoform 1 CD53 relocalizes PubMed
    CD53 downregulates PubMed
    CD63 antigen isoform A CD63 downregulates PubMed
    T-cell antigen CD7 precursor CD7 downregulates PubMed
    HLA class II histocompatibility antigen gamma chain isoform b CD74 interacts with PubMed
    CD81 antigen isoform 1 CD81 co-localizes with PubMed
    CD81 downregulates PubMed
    CD82 antigen isoform 1 CD82 downregulates PubMed
    CD83 antigen isoform a precursor CD83 downregulates PubMed
    M-phase inducer phosphatase 1 isoform a CDC25A stabilizes PubMed
    cadherin-1 isoform 1 preproprotein CDH1 interacts with PubMed
    centrosomal protein of 57 kDa isoform a CEP57 interacts with PubMed
    ceramide synthase 2 CERS2 interacts with PubMed
    cysteine and histidine-rich domain-containing protein 1 isoform a CHORDC1 interacts with PubMed
    contactin-associated protein 1 precursor CNTNAP1 interacts with PubMed
    collagen alpha-1(I) chain preproprotein COL1A1 upregulates PubMed
    casein kinase I isoform gamma-3 isoform 1 CSNK1G3 binds PubMed
    casein kinase II subunit alpha isoform a CSNK2A1 phosphorylated by PubMed
    CSNK2A1 phosphorylated by PubMed
    casein kinase II subunit alpha' CSNK2A2 phosphorylated by PubMed
    CSNK2A2 phosphorylated by PubMed
    casein kinase II subunit beta isoform 1 CSNK2B phosphorylated by PubMed
    CSNK2B phosphorylated by PubMed
    CSNK2B phosphorylated by PubMed
    catenin beta-1 isoform 1 CTNNB1 stabilizes PubMed
    CTNNB1 interacts with PubMed
    CTNNB1 stabilizes PubMed
    cullin-1 CUL1 interacts with PubMed
    C-X-C chemokine receptor type 3 isoform 1 CXCR3 downregulates PubMed
    C-X-C chemokine receptor type 4 isoform b CXCR4 downregulates PubMed
    diacylglycerol lipase-beta isoform 1 DAGLB interacts with PubMed
    dynamin-2 isoform 3 DNM2 inhibited by PubMed
    enhancer of mRNA-decapping protein 4 isoform 2 EDC4 interacts with PubMed
    early endosome antigen 1 EEA1 co-localizes with PubMed
    interferon-induced, double-stranded RNA-activated protein kinase isoform a EIF2AK2 inhibits PubMed
    tumor necrosis factor receptor superfamily member 6 isoform 1 precursor FAS interacts with PubMed
    F-box/WD repeat-containing protein 11 isoform A FBXW11 interacts with PubMed
    FBXW11 interacts with PubMed
    low affinity immunoglobulin gamma Fc region receptor III-A isoform a FCGR3A interacts with PubMed
    FCGR3A antagonizes PubMed
    flotillin-1 isoform 1 FLOT1 co-localizes with PubMed
    protein c-Fos FOS activates PubMed
    protein FosB isoform 1 FOSB activates PubMed
    guanylate-binding protein 5 isoform 1 GBP5 antagonizes PubMed
    golgin subfamily A member 4 isoform 2 GOLGA4 co-localizes with PubMed
    glycogen synthase kinase-3 beta isoform 1 GSK3B binds PubMed
    glycophorin-A isoform 1 precursor GYPA downregulates PubMed
    trifunctional enzyme subunit alpha, mitochondrial precursor HADHA interacts with PubMed
    trifunctional enzyme subunit beta, mitochondrial isoform 1 precursor HADHB interacts with PubMed
    hepatocyte growth factor isoform 1 preproprotein HGF downregulates PubMed
    hepatocyte growth factor-regulated tyrosine kinase substrate HGS interacts with PubMed
    HGS requires PubMed
    HGS cooperates with PubMed
    HGS interacts with PubMed
    HLA class I histocompatibility antigen, A alpha chain isoform A*03:01:01:01 precursor HLA-A downregulates PubMed
    HLA-A regulated by PubMed
    major histocompatibility complex, class I, B precursor HLA-B downregulates PubMed
    HLA-B regulated by PubMed
    HLA class I histocompatibility antigen, C alpha chain precursor HLA-C downregulates PubMed
    HLA-C regulated by PubMed
    HLA class II histocompatibility antigen, DM alpha chain precursor HLA-DMA modulates PubMed
    HLA class II histocompatibility antigen, DM beta chain precursor HLA-DMB modulates PubMed
    HLA class II histocompatibility antigen, DO alpha chain precursor HLA-DOA modulates PubMed
    HLA class II histocompatibility antigen, DO beta chain precursor HLA-DOB modulates PubMed
    HLA class II histocompatibility antigen, DP alpha 1 chain precursor HLA-DPA1 modulates PubMed
    HLA class II histocompatibility antigen, DP beta 1 chain precursor HLA-DPB1 modulates PubMed
    HLA class II histocompatibility antigen, DQ alpha 1 chain precursor HLA-DQA1 modulates PubMed
    HLA class II histocompatibility antigen, DQ alpha 2 chain precursor HLA-DQA2 modulates PubMed
    HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor HLA-DQB1 modulates PubMed
    HLA class II histocompatibility antigen, DQ beta 2 chain isoform 2 precursor HLA-DQB2 modulates PubMed
    HLA class II histocompatibility antigen, DR alpha chain precursor HLA-DRA modulates PubMed
    major histocompatibility complex, class II, DR beta 1 precursor HLA-DRB1 modulates PubMed
    major histocompatibility complex, class II, DR beta 3 precursor HLA-DRB3 modulates PubMed
    major histocompatibility complex, class II, DR beta 4 precursor HLA-DRB4 modulates PubMed
    major histocompatibility complex, class II, DR beta 5 precursor HLA-DRB5 modulates PubMed
    HLA class I histocompatibility antigen, alpha chain E precursor HLA-E regulated by PubMed
    HLA class I histocompatibility antigen, alpha chain F isoform 2 precursor HLA-F regulated by PubMed
    HLA class I histocompatibility antigen, alpha chain G isoform 2 precursor HLA-G regulated by PubMed
    very-long-chain 3-oxoacyl-CoA reductase HSD17B12 interacts with PubMed
    intercellular adhesion molecule 1 precursor ICAM1 downregulates PubMed
    intercellular adhesion molecule 2 precursor ICAM2 downregulates PubMed
    ICAM2 interacts with PubMed
    gamma-interferon-inducible protein 16 isoform 1 IFI16 antagonizes PubMed
    interferon-induced protein 44-like isoform 1 IFI44L downregulates PubMed
    interferon-induced protein with tetratricopeptide repeats 1 isoform 1 IFIT1 inhibits PubMed
    interferon-induced protein with tetratricopeptide repeats 2 IFIT2 inhibits PubMed
    interferon-induced protein with tetratricopeptide repeats 3 isoform a IFIT3 inhibits PubMed
    interferon-induced transmembrane protein 1 IFITM1 inhibits PubMed
    interferon alpha-1/13 precursor IFNA1 suppresses PubMed
    IFNA1 attenuates PubMed
    IFNA1 modulates PubMed
    IFNA1 disrupts PubMed
    IFNA1 inhibited by PubMed
    IFNA1 interacts with PubMed
    IFNA1 inhibits PubMed
    interferon alpha-10 precursor IFNA10 interacts with PubMed
    IFNA10 inhibits PubMed
    IFNA13 interacts with PubMed
    IFNA13 inhibits PubMed
    interferon alpha-14 precursor IFNA14 interacts with PubMed
    IFNA14 inhibits PubMed
    interferon alpha-16 precursor IFNA16 interacts with PubMed
    IFNA16 inhibits PubMed
    interferon alpha-17 precursor IFNA17 interacts with PubMed
    IFNA17 inhibits PubMed
    interferon alpha-2 precursor IFNA2 interacts with PubMed
    IFNA2 inhibits PubMed
    interferon alpha-21 precursor IFNA21 interacts with PubMed
    IFNA21 inhibits PubMed
    interferon alpha-4 precursor IFNA4 interacts with PubMed
    IFNA4 inhibits PubMed
    interferon alpha-5 precursor IFNA5 interacts with PubMed
    IFNA5 inhibits PubMed
    interferon alpha-6 precursor IFNA6 interacts with PubMed
    IFNA6 inhibits PubMed
    interferon alpha-7 precursor IFNA7 interacts with PubMed
    IFNA7 inhibits PubMed
    interferon alpha-8 precursor IFNA8 interacts with PubMed
    IFNA8 inhibits PubMed
    interferon beta precursor IFNB1 inhibits PubMed
    IFNB1 suppresses PubMed
    IFNB1 modulates PubMed
    IFNB1 attenuates PubMed
    IFNB1 modulates PubMed
    IFNB1 inhibited by PubMed
    interferon gamma receptor 1 isoform 1 precursor IFNGR1 modulates PubMed
    IFNGR1 downregulates PubMed
    insulin-like growth factor-binding protein 1 precursor IGFBP1 downregulates PubMed
    insulin-like growth factor-binding protein 2 isoform a precursor IGFBP2 downregulates PubMed
    inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1 IKBKB inhibits PubMed
    cytokine receptor common subunit gamma precursor IL2RG downregulates PubMed
    importin-9 IPO9 interacts with PubMed
    interferon regulatory factor 3 isoform 1 IRF3 induces cleavage of PubMed
    IRF3 induces cleavage of PubMed
    IRF3 induces cleavage of PubMed
    IRF3 induces cleavage of PubMed
    IRF3 co-localizes with PubMed
    IRF3 interacts with PubMed
    IRF3 complexes with PubMed
    ubiquitin-like protein ISG15 ISG15 inhibits PubMed
    interferon-stimulated gene 20 kDa protein isoform a ISG20 inhibits PubMed
    transcription factor Jun JUN activates PubMed
    transcription factor JunB JUNB activates PubMed
    transcription factor JunD isoform JunD-FL JUND activates PubMed
    potassium channel subfamily K member 3 KCNK3 interacts with PubMed
    KCNK3 interacts with PubMed
    killer cell immunoglobulin-like receptor 2DL2 precursor KIR2DL2 inhibits PubMed
    NKG2-D type II integral membrane protein KLRK1 downregulates PubMed
    lysosome-associated membrane glycoprotein 1 precursor LAMP1 downregulates PubMed
    LAMP1 co-localizes with PubMed
    lysosome-associated membrane glycoprotein 2 isoform A precursor LAMP2 downregulates PubMed
    LAMP2 co-localizes with PubMed
    tyrosine-protein kinase Lck isoform a LCK relocalizes PubMed
    leukocyte immunoglobulin-like receptor subfamily A member 4 precursor LILRA4 requires PubMed
    leucine-rich PPR motif-containing protein, mitochondrial precursor LRPPRC interacts with PubMed
    mitochondrial antiviral-signaling protein isoform 2 MAVS degrades PubMed
    MAVS blocks PubMed
    MHC class I polypeptide-related sequence A isoform 1 (MICA*001) precursor MICA downregulates PubMed
    macrophage migration inhibitory factor MIF inhibited by PubMed
    72 kDa type IV collagenase isoform 1 preproprotein MMP2 upregulates PubMed
    moesin MSN interacts with PubMed
    mucin-1 isoform 1 precursor MUC1 downregulates PubMed
    interferon-induced GTP-binding protein Mx1 isoform a MX1 inhibits PubMed
    NEDD8-activating enzyme E1 regulatory subunit isoform b NAE1 depends on PubMed
    condensin-2 complex subunit D3 isoform 1 NCAPD3 interacts with PubMed
    NEDD8 NEDD8 interacts with PubMed
    nuclear factor of activated T-cells 5 isoform c NFAT5 regulates PubMed
    nuclear factor of activated T-cells, cytoplasmic 1 isoform B NFATC1 regulates PubMed
    nuclear factor of activated T-cells, cytoplasmic 2 isoform B NFATC2 regulates PubMed
    nuclear factor of activated T-cells, cytoplasmic 3 isoform 2 NFATC3 regulates PubMed
    nuclear factor of activated T-cells, cytoplasmic 4 isoform 2 NFATC4 regulates PubMed
    nuclear factor NF-kappa-B p105 subunit isoform 1 NFKB1 modulates PubMed
    NFKB1 inhibits PubMed
    NFKB1 inhibits PubMed
    NFKB1 inhibits PubMed
    NFKB1 inhibits PubMed
    NFKB1 inhibits PubMed
    NF-kappa-B inhibitor alpha NFKBIA inhibits PubMed
    NFKBIA inhibits PubMed
    NFKBIA stabilizes PubMed
    NFKBIA stabilizes PubMed
    serine/threonine-protein kinase NLK NLK binds PubMed
    nuclear protein localization protein 4 homolog isoform 1 NPLOC4 cooperates with PubMed
    2'-5'-oligoadenylate synthase 1 isoform 3 OAS1 antagonizes PubMed
    poly PARP1 induces cleavage of PubMed
    type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2 PIP4P1 interacts with PubMed
    serine/threonine-protein kinase N2 isoform 1 PKN2 binds PubMed
    serine/threonine-protein kinase PLK1 PLK1 binds PubMed
    serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1 PPP2CA dephosphorylated by PubMed
    serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB dephosphorylated by PubMed
    serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform 1 PPP2R1A dephosphorylated by PubMed
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a PPP2R5E interacts with PubMed
    prolactin regulatory element-binding protein isoform 1 PREB interacts with PubMed
    DNA-dependent protein kinase catalytic subunit isoform 1 PRKDC interacts with PubMed
    prostaglandin E synthase 3 isoform a PTGES3 interacts with PubMed
    poliovirus receptor isoform alpha precursor PVR downregulates PubMed
    PVR relocalizes PubMed
    PVR downregulates PubMed
    PVR downregulates PubMed
    UL-16 binding protein 5 preproprotein RAET1G downregulates PubMed
    UL16-binding protein 6 precursor RAET1L downregulates PubMed
    ran-specific GTPase-activating protein isoform 2 RANBP1 interacts with PubMed
    RNA-binding motif protein, Y chromosome, family 1 member A1 isoform 1 RBMY1A1 interacts with PubMed
    transcription factor p65 isoform 1 RELA inhibits PubMed
    RELA inhibited by PubMed
    E3 ubiquitin-protein ligase RNF115 RNF115 inhibits PubMed
    E3 ubiquitin-protein ligase RNF213 isoform 2 RNF213 interacts with PubMed
    ribosomal protein S6 kinase alpha-5 isoform a RPS6KA5 binds PubMed
    S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 isoform 1 RSAD2 inhibits PubMed
    reticulon-3 isoform a RTN3 interacts with PubMed
    reticulon-4 isoform C RTN4 interacts with PubMed
    secretory carrier-associated membrane protein 3 isoform 1 SCAMP3 interacts with PubMed
    SCY1-like protein 2 isoform 1 SCYL2 inhibited by PubMed
    SCYL2 inhibited by PubMed
    SCYL2 inhibited by PubMed
    SCYL2 binds PubMed
    L-selectin precursor SELL inhibits PubMed
    SELL downregulates PubMed
    P-selectin glycoprotein ligand 1 isoform 2 precursor SELPLG downregulates PubMed
    semaphorin-4D isoform 1 precursor SEMA4D downregulates PubMed
    semaphorin-7A isoform 1 preproprotein SEMA7A downregulates PubMed
    sphingosine-1-phosphate lyase 1 SGPL1 interacts with PubMed
    small glutamine-rich tetratricopeptide repeat-containing protein alpha SGTA interacts with PubMed
    SGTA binds PubMed
    SGTA interacts with PubMed
    S-phase kinase-associated protein 1 isoform a SKP1 interacts with PubMed
    SLAM family member 6 isoform 2 precursor SLAMF6 downregulates PubMed
    SLAMF6 downregulates PubMed
    SLAMF6 downregulates PubMed
    SLAMF6 modulates PubMed
    SLAMF6 modulates PubMed
    SLAMF6 downregulates PubMed
    SLAMF6 interacts with PubMed
    SLAMF6 binds PubMed
    long-chain fatty acid transport protein 4 SLC27A4 interacts with PubMed
    sodium-coupled neutral amino acid symporter 1 isoform 1 SLC38A1 degrades PubMed
    SLC38A1 ubiquitinates PubMed
    SLC38A1 binds PubMed
    SLC38A1 depletes PubMed
    SLC38A1 downregulates PubMed
    SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform 1 precursor SLIRP interacts with PubMed
    survival motor neuron protein isoform d SMN1 upregulates PubMed
    zinc finger protein SNAI1 SNAI1 upregulates PubMed
    SNAI1 upregulates PubMed
    zinc finger protein SNAI2 SNAI2 upregulates PubMed
    SNAI2 upregulates PubMed
    clathrin coat assembly protein AP180 isoform a SNAP91 inhibited by PubMed
    leukosialin precursor SPN antagonizes PubMed
    serine/arginine-rich splicing factor 5 isoform 1 SRSF5 regulated by PubMed
    signal transducer and activator of transcription 1-alpha/beta isoform alpha STAT1 inhibits PubMed
    TBC1 domain family member 15 isoform 1 TBC1D15 interacts with PubMed
    FAST kinase domain-containing protein 4 isoform 1 TBRG4 interacts with PubMed
    transferrin receptor protein 1 isoform 1 TFRC downregulates PubMed
    TFRC co-localizes with PubMed
    transforming growth factor beta-1 proprotein preproprotein TGFB1 interacts with PubMed
    TGFB1 activates PubMed
    transforming growth factor beta-2 proprotein isoform 2 preproprotein TGFB2 interacts with PubMed
    TGFB2 activates PubMed
    transforming growth factor beta-3 proprotein isoform 1 preproprotein TGFB3 interacts with PubMed
    TGFB3 activates PubMed
    TGF-beta receptor type-1 isoform 1 precursor TGFBR1 interacts with PubMed
    TGF-beta receptor type-2 isoform B precursor TGFBR2 interacts with PubMed
    transforming growth factor beta receptor type 3 isoform a precursor TGFBR3 interacts with PubMed
    trans-Golgi network integral membrane protein 2 isoform 1 precursor TGOLN2 co-localizes with PubMed
    TGOLN2 co-localizes with PubMed
    transmembrane protein 192 TMEM192 interacts with PubMed
    tumor necrosis factor TNF inhibits PubMed
    tumor necrosis factor receptor superfamily member 1B precursor TNFRSF1B downregulates PubMed
    tumor necrosis factor receptor superfamily member 8 isoform 1 precursor TNFRSF8 downregulates PubMed
    cellular tumor antigen p53 isoform a TP53 upregulates PubMed
    TP53 stabilizes PubMed
    TNF receptor-associated factor 1 isoform a TRAF1 downregulates PubMed
    tripartite motif-containing protein 5 isoform alpha TRIM5 inhibits PubMed
    tumor susceptibility gene 101 protein TSG101 requires PubMed
    tetraspanin-7 TSPAN7 downregulates PubMed
    testis-specific serine/threonine-protein kinase 2 TSSK2 binds PubMed
    ubiquitin-associated protein 1 isoform 1 UBAP1 requires PubMed
    UBAP1 requires PubMed
    ubiquitin recognition factor in ER-associated degradation protein 1 isoform A UFD1 cooperates with PubMed
    UL16-binding protein 2 preproprotein ULBP2 downregulates PubMed
    uroporphyrinogen decarboxylase UROD upregulates PubMed
    vascular cell adhesion protein 1 isoform a precursor VCAM1 upregulates PubMed
    transitional endoplasmic reticulum ATPase isoform 1 VCP cooperates with PubMed
    VCP cooperates with PubMed
    vascular endothelial growth factor A, long form isoform b VEGFA upregulates PubMed
    vacuolar protein sorting-associated protein 4A VPS4A cooperates with PubMed
    vacuolar protein sorting-associated protein 4B VPS4B cooperates with PubMed
    WD repeat-containing protein 81 isoform 1 WDR81 requires PubMed
    exportin-1 isoform 1 XPO1 interacts with PubMed
    exportin-4 isoform 1 XPO4 interacts with PubMed
    exportin-5 XPO5 interacts with PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    Vpu
    NP_057855.1
    • Vpu and gp160 are translated from different reading frames of the same bicistronic mRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001802.1 Reference assembly

      Range
      5608..5856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_057855.1 Vpu [Human immunodeficiency virus 1]

      See identical proteins and their annotated locations for NP_057855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05919, P05920, P05922, P69699, P69700, Q9WB91
      UniProtKB/TrEMBL
      Q74598, Q76PP7
      Conserved Domains (1) summary
      pfam00558
      Location:23 → 79
      Vpu; Vpu protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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