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    IGF1 insulin like growth factor 1 [ Bos taurus (cattle) ]

    Gene ID: 281239, updated on 3-Apr-2024

    Summary

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    Official Symbol
    IGF1provided by VGNC
    Official Full Name
    insulin like growth factor 1provided by VGNC
    Primary source
    VGNC:VGNC:30076
    See related
    BGD:BT11525; Ensembl:ENSBTAG00000011082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    IGF-1; IGF-I
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (66186011..66264048, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene reticulon-3-like Neighboring gene T-complex protein 1 subunit epsilon-like Neighboring gene uncharacterized LOC112446717 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC101902701

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis]. Martens H. Tierarztl Prax Ausg G Grosstiere Nutztiere, 2023 Apr. PMID 37230145
    2. Polymorphism of Insulin-like Growth Factor 1 Gene (IGF1/TasI, IGF1/SnaBI, IGF1/RsaI) and the Association with Daily Gain of Pesisir Cattle Local Breed from West Sumatera, Indonesia. Yurnalis, et al. Pak J Biol Sci, 2017. PMID 29023078
    3. Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling. Lu Y, et al. Am J Physiol Regul Integr Comp Physiol, 2017 May 1. PMID 28228415, Free PMC Article
    4. Transcriptomics of liver and muscle in Holstein cows genetically divergent for fertility highlight differences in nutrient partitioning and inflammation processes. Moran B, et al. BMC Genomics, 2016 Aug 11. PMID 27514375, Free PMC Article
    5. Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle. Chung HY, et al. Genet Mol Res, 2015 Apr 10. PMID 25966067

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis].
      Title: [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis].
    2. Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
      Title: Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
    3. Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.
      Title: Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.
    4. the addition of PAPP-A did not affect embryo yield and blastocyst survival, higher IGF-1 levels may affect embryo competence through differential expression of genes involved in lipid metabolism, oocyte competence, and mitochondrial function.
      Title: Use of pregnancy-associated plasma protein-A during oocyte in vitro maturation increases IGF-1 and affects the transcriptional profile of cumulus cells and embryos from Nelore cows.
    5. This study showed that the IGF-1 SnaBI TT appears to be associated with fewer days to ovulation and lesser calving to conseption interval of lactating dairy cows and had an additive association with the GHR AluI T allele on indicators for improvement of fertility.
      Title: Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows.
    6. LncRNA H19 participated in the regulation of the proliferation and apoptosis of male germline stem cells via the IGF-1 signaling pathway
      Title: H19 regulates the proliferation of bovine male germline stem cells via IGF-1 signaling pathway.
    7. plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I have a relationship with scrotal circumference and testicular weight in Japanese Black beef bull calves
      Title: Relationships of plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I concentrations with scrotal circumference and testicular weight in Japanese Black beef bull calves.
    8. These results suggest that reduced secretions of IGF-I, INSL3, and inhibin surrounding puberty may be associated with semen aberration in beef bulls.
      Title: Plasma IGF-I, INSL3, testosterone, inhibin concentrations and scrotal circumferences surrounding puberty in Japanese Black beef bulls with normal and abnormal semen.
    9. IGF1/RsaI was associated with average daily weight gain in cattle.
      Title: Polymorphism of Insulin-like Growth Factor 1 Gene (IGF1/TasI, IGF1/SnaBI, IGF1/RsaI) and the Association with Daily Gain of Pesisir Cattle Local Breed from West Sumatera, Indonesia.
    10. Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
      Title: Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (63)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor I
    Names
    class 1 insulin-like growth factor I preproprotein
    insulin growth factor-1
    insulin-like growth factor 1 (somatomedin C)
    insulin-like growth factor I (somatomedin C)
    prepro-IGF-I
    somatomedin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077828.1 → NP_001071296.1  insulin-like growth factor I preproprotein

      See identical proteins and their annotated locations for NP_001071296.1

      Status: PROVISIONAL

      Source sequence(s)
      BC126802
      UniProtKB/Swiss-Prot
      P07455
      UniProtKB/TrEMBL
      F2X2F0, Q9N1C1
      Related
      ENSBTAP00000082984.1, ENSBTAT00000103741.1
      Conserved Domains (1) summary
      cd04368
      Location:50 → 117
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66186011..66264048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005206497.5 → XP_005206554.1  insulin-like growth factor I isoform X5

      See identical proteins and their annotated locations for XP_005206554.1

      UniProtKB/TrEMBL
      Q9N1C1
      Related
      ENSBTAP00000014713.6, ENSBTAT00000014713.7
      Conserved Domains (1) summary
      cd04368
      Location:49 → 116
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    2. XM_005206499.5 → XP_005206556.1  insulin-like growth factor I isoform X7

      See identical proteins and their annotated locations for XP_005206556.1

      UniProtKB/TrEMBL
      F2X2F2, Q9N1C1
      Conserved Domains (1) summary
      cd04368
      Location:34 → 101
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    3. XM_005206500.5 → XP_005206557.1  insulin-like growth factor I isoform X8

      See identical proteins and their annotated locations for XP_005206557.1

      UniProtKB/TrEMBL
      Q9N1C1
      Conserved Domains (1) summary
      cd04368
      Location:33 → 100
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    4. XM_059886094.1 → XP_059742077.1  insulin-like growth factor I isoform X1

      UniProtKB/TrEMBL
      F2X2F1

    5. XM_024991342.2 → XP_024847110.1  insulin-like growth factor I isoform X6

      Conserved Domains (1) summary
      cd04368
      Location:50 → 117
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

    6. XM_015471064.3 → XP_015326550.1  insulin-like growth factor I isoform X4

      Conserved Domains (2) summary
      cd04368
      Location:33 → 100
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam15724
      Location:108 → 157
      TMEM119; TMEM119 family

    7. XM_015471062.3 → XP_015326548.1  insulin-like growth factor I isoform X2

      Related
      ENSBTAP00000055243.2, ENSBTAT00000063328.3
      Conserved Domains (2) summary
      cd04368
      Location:49 → 116
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam15724
      Location:124 → 173
      TMEM119; TMEM119 family

    8. XM_015471061.3 → XP_015326547.1  insulin-like growth factor I isoform X1

      UniProtKB/TrEMBL
      F2X2F1
      Conserved Domains (2) summary
      cd04368
      Location:50 → 117
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam15724
      Location:125 → 174
      TMEM119; TMEM119 family

    9. XM_015471063.3 → XP_015326549.1  insulin-like growth factor I isoform X3

      UniProtKB/TrEMBL
      F2X2F3
      Related
      ENSBTAP00000041154.3, ENSBTAT00000043595.4
      Conserved Domains (2) summary
      cd04368
      Location:34 → 101
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam15724
      Location:109 → 158
      TMEM119; TMEM119 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07455.2 GenPept UniProtKB/Swiss-Prot:P07455

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