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    RANBP9 RAN binding protein 9 [ Homo sapiens (human) ]

    Gene ID: 10048, updated on 5-Jan-2022

    Summary

    Official Symbol
    RANBP9provided by HGNC
    Official Full Name
    RAN binding protein 9provided by HGNC
    Primary source
    HGNC:HGNC:13727
    See related
    Ensembl:ENSG00000010017 MIM:603854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BPM-L; BPM90; RANBPM; RanBP7
    Summary
    This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 72.2), esophagus (RPKM 38.9) and 23 other tissues See more
    Orthologs
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    Genomic context

    See RANBP9 in Genome Data Viewer
    Location:
    6p23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (13621498..13711835, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13621730..13712067, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374937 Neighboring gene sirtuin 5 Neighboring gene uncharacterized LOC105374938 Neighboring gene nucleolar protein 7 Neighboring gene Sharpr-MPRA regulatory region 12249 Neighboring gene Sharpr-MPRA regulatory region 2979 Neighboring gene mitochondrial calcium uniporter regulator 1 Neighboring gene uncharacterized LOC107986571

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies nuclear import-export proteins Exp2 and RanBP9 as IN-binding partners PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of microtubule associated complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ran-binding protein 9
    Names
    Ran Binding Protein in the Microtubule organizing center
    novel centrosomal protein RanBPM
    ran binding protein, centrosomal
    ran-binding protein M

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005493.3NP_005484.2  ran-binding protein 9

      See identical proteins and their annotated locations for NP_005484.2

      Status: REVIEWED

      Source sequence(s)
      AB055311, AF306510, BC052781, Z93020
      Consensus CDS
      CCDS4529.1
      UniProtKB/Swiss-Prot
      Q96S59
      UniProtKB/TrEMBL
      A0A024QZW3
      Related
      ENSP00000011619.3, ENST00000011619.6
      Conserved Domains (4) summary
      smart00667
      Location:364397
      LisH; Lissencephaly type-1-like homology motif
      smart00757
      Location:616708
      CRA; CT11-RanBPM
      cd12909
      Location:189331
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
      pfam10607
      Location:403457
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      13621498..13711835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514205.2XP_011512507.1  ran-binding protein 9 isoform X1

      Conserved Domains (5) summary
      smart00667
      Location:364397
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:403459
      CTLH; C-terminal to LisH motif
      smart00757
      Location:526618
      CRA; CT11-RanBPM
      pfam10607
      Location:403618
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:189331
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
    2. XM_006714945.2XP_006715008.1  ran-binding protein 9 isoform X3

      See identical proteins and their annotated locations for XP_006715008.1

      UniProtKB/Swiss-Prot
      Q96S59
      Conserved Domains (4) summary
      smart00667
      Location:135168
      LisH; Lissencephaly type-1-like homology motif
      smart00757
      Location:387479
      CRA; CT11-RanBPM
      cd12909
      Location:1102
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
      pfam10607
      Location:174228
      CLTH; CTLH/CRA C-terminal to LisH motif domain
    3. XM_017010149.1XP_016865638.1  ran-binding protein 9 isoform X2

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