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    Ctse cathepsin E [ Mus musculus (house mouse) ]

    Gene ID: 13034, updated on 5-Aug-2022

    Summary

    Official Symbol
    Ctseprovided by MGI
    Official Full Name
    cathepsin Eprovided by MGI
    Primary source
    MGI:MGI:107361
    See related
    Ensembl:ENSMUSG00000004552 AllianceGenome:MGI:107361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CE; CatE; A430072O03Rik; C920004C08Rik
    Summary
    This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in stomach adult (RPKM 438.1), bladder adult (RPKM 70.7) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Ctse in Genome Data Viewer
    Location:
    1 E4; 1 57.14 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131566052..131603245)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131638314..131675507)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (133534891..133572084)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene arginine vasopressin receptor 1B Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene Neighboring gene RAB7B, member RAS oncogene family Neighboring gene predicted gene, 30104

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aspartic-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007799.3NP_031825.2  cathepsin E preproprotein

      See identical proteins and their annotated locations for NP_031825.2

      Status: REVIEWED

      Source sequence(s)
      AC120217, AC138277, AK145875
      Consensus CDS
      CCDS15271.1
      UniProtKB/Swiss-Prot
      P70269, Q4FK00
      Related
      ENSMUSP00000073072.7, ENSMUST00000073350.13
      Conserved Domains (3) summary
      pfam00026
      Location:78395
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:2250
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:79394
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131566052..131603245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)