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    Psma3 proteasome subunit alpha 3 [ Mus musculus (house mouse) ]

    Gene ID: 19167, updated on 5-Jan-2022

    Summary

    Official Symbol
    Psma3provided by MGI
    Official Full Name
    proteasome subunit alpha 3provided by MGI
    Primary source
    MGI:MGI:104883
    See related
    Ensembl:ENSMUSG00000060073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmpc8
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasomal protein catabolic process and regulation of endopeptidase activity. Part of proteasome core complex. Is expressed in several structures, including alimentary system; central nervous system; cranium; dorsal root ganglion; and lung. Orthologous to human PSMA3 (proteasome 20S subunit alpha 3). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Ubiquitous expression in placenta adult (RPKM 35.7), CNS E11.5 (RPKM 28.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Psma3 in Genome Data Viewer
    Location:
    12; 12 C2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71016057..71042651)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (70969283..70995877)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (72075610..72095924)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ARP10 actin-related protein 10 Neighboring gene nuclear encoded tRNA lysine 17 (anticodon CTT) Neighboring gene RIKEN cDNA 3110056K07 gene Neighboring gene AT rich interactive domain 4A (RBP1-like) Neighboring gene translocase of outer mitochondrial membrane 20-like Neighboring gene predicted gene, 32906

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis involved in cellular protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proteasome subunit alpha type-3
    Names
    macropain subunit C8
    multicatalytic endopeptidase complex subunit C8
    proteasome (prosome, macropain) subunit, alpha type 3
    proteasome component C8
    proteasome subunit K
    NP_001297524.1
    NP_001297525.1
    NP_035314.3
    XP_017170485.1
    XP_030102476.1
    XP_030102477.1
    XP_036013150.1
    XP_036013151.1
    XP_036013152.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310595.1NP_001297524.1  proteasome subunit alpha type-3 isoform b

      See identical proteins and their annotated locations for NP_001297524.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC132325, AI303320, AK169577, BY159585
      Consensus CDS
      CCDS79119.1
      UniProtKB/TrEMBL
      E0CX62, Q3TEL1
      Conserved Domains (1) summary
      cl00467
      Location:1142
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    2. NM_001310596.1NP_001297525.1  proteasome subunit alpha type-3 isoform b

      See identical proteins and their annotated locations for NP_001297525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC132325
      Consensus CDS
      CCDS79119.1
      UniProtKB/TrEMBL
      E0CX62
      Conserved Domains (1) summary
      cl00467
      Location:1142
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    3. NM_011184.5NP_035314.3  proteasome subunit alpha type-3 isoform a

      See identical proteins and their annotated locations for NP_035314.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC132325, AI303320, AK168495, BY159585
      Consensus CDS
      CCDS25961.1
      UniProtKB/Swiss-Prot
      O70435
      UniProtKB/TrEMBL
      Q58EV4
      Related
      ENSMUSP00000125548.2, ENSMUST00000160027.8
      Conserved Domains (1) summary
      cd03751
      Location:5217
      proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      71016057..71042651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314996.2XP_017170485.1  proteasome subunit alpha type-3 isoform X1

      UniProtKB/Swiss-Prot
      O70435
      UniProtKB/TrEMBL
      Q58EV4
      Conserved Domains (1) summary
      cd03751
      Location:5217
      proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
    2. XM_030246616.1XP_030102476.1  proteasome subunit alpha type-3 isoform X1

      Conserved Domains (1) summary
      cd03751
      Location:5217
      proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
    3. XM_036157257.1XP_036013150.1  proteasome subunit alpha type-3 isoform X2

      Conserved Domains (1) summary
      cd03751
      Location:5195
      proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
    4. XM_036157259.1XP_036013152.1  proteasome subunit alpha type-3 isoform X4

      Conserved Domains (1) summary
      cl00467
      Location:1120
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    5. XM_036157258.1XP_036013151.1  proteasome subunit alpha type-3 isoform X4

      Conserved Domains (1) summary
      cl00467
      Location:1120
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    6. XM_030246617.2XP_030102477.1  proteasome subunit alpha type-3 isoform X3

      Related
      ENSMUSP00000124894.3, ENSMUST00000160864.8
      Conserved Domains (1) summary
      cl00467
      Location:1142
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
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