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    Spp1 secreted phosphoprotein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25353, updated on 25-Jan-2022

    Summary

    Symbol
    Spp1provided by RGD
    Full Name
    secreted phosphoprotein 1provided by RGD
    Primary source
    RGD:3752
    See related
    Ensembl:ENSRNOG00000043451 AllianceGenome:RGD:3752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OSP
    Summary
    Predicted to enable extracellular matrix binding activity and integrin binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; osteoblast differentiation; and positive regulation of bone resorption. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in Kidney (RPKM 3427.7), Adrenal (RPKM 462.1) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Spp1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5308885..5315120, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (6673686..6679965, complement)

    Chromosome 14 - NC_051349.1Genomic Context describing neighboring genes Neighboring gene similar to THO complex subunit 2 (Tho2) Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene uncharacterized LOC100910198 Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene integrin-binding sialoprotein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in androgen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to testosterone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within collecting duct development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of collateral sprouting of intact axon in response to injury IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of bone resorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of estradiol secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to steroid hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to vitamin D ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within urate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    osteopontin
    Names
    SPP-1
    Sialoprotein (osteopontin)
    bone sialoprotein 1
    osteopontin-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012881.2NP_037013.2  osteopontin precursor

      See identical proteins and their annotated locations for NP_037013.2

      Status: VALIDATED

      Source sequence(s)
      BC078874, BU759036, CV102664
      UniProtKB/Swiss-Prot
      P08721
      Related
      ENSRNOP00000062358.2, ENSRNOT00000067875.5
      Conserved Domains (1) summary
      pfam00865
      Location:22317
      Osteopontin; Osteopontin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051349.1 Reference mRatBN7.2 Primary Assembly

      Range
      5308885..5315120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769996.3XP_008768218.1  osteopontin isoform X1

      See identical proteins and their annotated locations for XP_008768218.1

      UniProtKB/Swiss-Prot
      P08721
      Conserved Domains (1) summary
      pfam00865
      Location:22317
      Osteopontin; Osteopontin
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