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    aco2 aconitase 2, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 322670, updated on 5-Jan-2022

    Summary

    Official Symbol
    aco2provided by ZNC
    Official Full Name
    aconitase 2, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1390
    See related
    Ensembl:ENSDARG00000007294
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb1017; wu:fa10e03; wu:fb69g04; wu:fc20c11
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including adaxial cell; heart tube; musculature system; nervous system; and pronephric duct. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Nov 2021]
    Orthologs
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    Genomic context

    See aco2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (19106571..19119154, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18984697..18997280, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 12 NC_007123.5 (20202853..20215436, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 2Cb Neighboring gene cold shock domain containing C2, RNA binding a Neighboring gene PHD finger protein 5A Neighboring gene TEF transcription factor, PAR bZIP family member a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    aconitate hydratase, mitochondrial
    NP_944590.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198908.1NP_944590.1  aconitate hydratase, mitochondrial

      See identical proteins and their annotated locations for NP_944590.1

      Status: PROVISIONAL

      Source sequence(s)
      BC058049
      UniProtKB/TrEMBL
      Q6PEI6
      Related
      ENSDARP00000123883.2, ENSDART00000149180.3
      Conserved Domains (3) summary
      cd01584
      Location:97507
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:589737
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:47777
      aconitase_mito; aconitate hydratase, mitochondrial

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      19106571..19119154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      328446..344007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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