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    fbp1a fructose-1,6-bisphosphatase 1a [ Danio rerio (zebrafish) ]

    Gene ID: 335231, updated on 25-Jan-2022

    Summary

    Official Symbol
    fbp1aprovided by ZNC
    Official Full Name
    fructose-1,6-bisphosphatase 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7171
    See related
    Ensembl:ENSDARG00000021366 AllianceGenome:ZFIN:ZDB-GENE-030131-7171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fbp1; fbp1l; fk92h02; zgc:64096; wu:fk92h02
    Summary
    Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Predicted to be involved in several processes, including fructose 1,6-bisphosphate metabolic process; hexose metabolic process; and sucrose biosynthetic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; lens; liver; and solid lens vesicle. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1). [provided by Alliance of Genome Resources, Nov 2021]
    Orthologs
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    Genomic context

    See fbp1a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (44833313..44843738, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (44233160..44243585, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 5 NC_007116.5 (46451895..46462230, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene cathepsin La Neighboring gene fructose-1,6-bisphosphatase 2 Neighboring gene KN motif and ankyrin repeat domains 1a Neighboring gene doublesex and mab-3 related transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sucrose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    fructose-1,6-bisphosphatase 1a
    Names
    fructose-1,6-bisphosphatase 1, like
    NP_956236.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199942.2NP_956236.1  fructose-1,6-bisphosphatase 1a

      See identical proteins and their annotated locations for NP_956236.1

      Status: VALIDATED

      Source sequence(s)
      CR388096, EH585004
      UniProtKB/TrEMBL
      Q6PFT1
      Related
      ENSDARP00000004866.7, ENSDART00000003926.8
      Conserved Domains (1) summary
      cd00354
      Location:18332
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      44833313..44843738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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