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    hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) [ Danio rerio (zebrafish) ]

    Gene ID: 394060, updated on 19-May-2022

    Summary

    Official Symbol
    hmgcs1provided by ZNC
    Official Full Name
    3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1042
    See related
    Ensembl:ENSDARG00000103025 AllianceGenome:ZFIN:ZDB-GENE-040426-1042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56481
    Summary
    Predicted to enable hydroxymethylglutaryl-CoA synthase activity. Acts upstream of or within animal organ development and oligodendrocyte development. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin musculature; and yolk syncytial layer. Orthologous to several human genes including HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See hmgcs1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (6010562..6034410)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (6009381..6033201)
    103 previous assembly Zv9 (GCF_000002035.4) 10 NC_007121.5 (7996234..8020026)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase pim-3-like Neighboring gene mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase Neighboring gene E3 ubiquitin-protein ligase RNF12-B-like Neighboring gene serine/threonine-protein kinase pim-2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC56481

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydroxymethylglutaryl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydroxymethylglutaryl-CoA synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within acetyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neural crest cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    hydroxymethylglutaryl-CoA synthase, cytoplasmic
    Names
    3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
    NP_957379.2
    XP_005155548.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201085.2NP_957379.2  hydroxymethylglutaryl-CoA synthase, cytoplasmic

      Status: VALIDATED

      Source sequence(s)
      BX322605
      Conserved Domains (3) summary
      TIGR01833
      Location:20477
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam01154
      Location:23193
      HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
      pfam08540
      Location:194477
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      6010562..6034410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155491.3XP_005155548.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A0R4IQG1
      Related
      ENSDARP00000145051.1, ENSDART00000190025.1
      Conserved Domains (3) summary
      TIGR01833
      Location:13470
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam01154
      Location:16186
      HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
      pfam08540
      Location:187470
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal