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    NTAQ1 N-terminal glutamine amidase 1 [ Homo sapiens (human) ]

    Gene ID: 55093, updated on 22-May-2022

    Summary

    Official Symbol
    NTAQ1provided by HGNC
    Official Full Name
    N-terminal glutamine amidase 1provided by HGNC
    Primary source
    HGNC:HGNC:25490
    See related
    Ensembl:ENSG00000156795 AllianceGenome:HGNC:25490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WDYHV1; C8orf32
    Summary
    Predicted to enable protein-N-terminal glutamine amidohydrolase activity. Predicted to be involved in cellular protein modification process. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 1.6), ovary (RPKM 1.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NTAQ1 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (123416725..123475696)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (124547829..124579159)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124428965..124460331)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATPase family AAA domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 2006 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 6 Neighboring gene U4 spliceosomal RNA Neighboring gene F-box protein 32 Neighboring gene RN7SK pseudogene 155

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-N-terminal asparagine amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-N-terminal glutamine amidohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-N-terminal glutamine amidohydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in protein modification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein modification process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein N-terminal glutamine amidohydrolase
    Names
    N-terminal Gln amidase
    WDYHV motif containing 1
    WDYHV motif-containing protein 1
    nt(Q)-amidase
    protein NH2-terminal glutamine deamidase
    NP_001269953.1
    NP_001269956.1
    NP_060494.1
    XP_006716660.1
    XP_047277879.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001283024.1NP_001269953.1  protein N-terminal glutamine amidohydrolase isoform 2

      See identical proteins and their annotated locations for NP_001269953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC021305, AK293492
      Consensus CDS
      CCDS64965.1
      UniProtKB/Swiss-Prot
      Q96HA8
      Related
      ENSP00000430427.1, ENST00000523984.5
      Conserved Domains (1) summary
      pfam09764
      Location:1132
      Nt_Gln_amidase; N-terminal glutamine amidase
    2. NM_001283027.1NP_001269956.1  protein N-terminal glutamine amidohydrolase isoform 3

      See identical proteins and their annotated locations for NP_001269956.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and has an alternate internal exon compared to variant 1. These differences cause translation initiation at a alternate start codon compared to variant 1. The encoded isoform (3) is shorter and has a disntinct N-teminus compared to isoform 1.
      Source sequence(s)
      AC021305, AU119047, BG528966
      Conserved Domains (1) summary
      pfam09764
      Location:11124
      Nt_Gln_amidase; N-terminal glutamine amidase
    3. NM_018024.3NP_060494.1  protein N-terminal glutamine amidohydrolase isoform 1

      See identical proteins and their annotated locations for NP_060494.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC021305, AK001066
      Consensus CDS
      CCDS6344.1
      UniProtKB/Swiss-Prot
      Q96HA8
      Related
      ENSP00000287387.2, ENST00000287387.7
      Conserved Domains (1) summary
      pfam09764
      Location:23192
      Nt_Gln_amidase; N-terminal glutamine amidase

    RNA

    1. NR_133926.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon and includes an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC021305, AK001066, AL528914

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      123416725..123475696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421923.1XP_047277879.1  protein N-terminal glutamine amidohydrolase isoform X2

    2. XM_006716597.4XP_006716660.1  protein N-terminal glutamine amidohydrolase isoform X1

      UniProtKB/TrEMBL
      E5RHC2
      Related
      ENSP00000428615.1, ENST00000523356.1
      Conserved Domains (1) summary
      pfam09764
      Location:23182
      Nt_Gln_amidase; N-terminal glutamine amidase

    RNA

    1. XR_007060742.1 RNA Sequence

    2. XR_002956636.2 RNA Sequence

    3. XR_002956635.2 RNA Sequence

    4. XR_007060741.1 RNA Sequence

    5. XR_007060738.1 RNA Sequence

    6. XR_007060736.1 RNA Sequence

    7. XR_928337.4 RNA Sequence

    8. XR_007060739.1 RNA Sequence

    9. XR_007060740.1 RNA Sequence

    10. XR_007060737.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      124547829..124579159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)