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    cd44a CD44 molecule (Indian blood group) a [ Danio rerio (zebrafish) ]

    Gene ID: 797357, updated on 22-Sep-2022

    Summary

    Official Symbol
    cd44aprovided by ZNC
    Official Full Name
    CD44 molecule (Indian blood group) aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110429-1
    See related
    Ensembl:ENSDARG00000087863 AllianceGenome:ZFIN:ZDB-GENE-110429-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa99e04; wu:fa99e04
    Summary
    Predicted to enable hyaluronic acid binding activity and transmembrane signaling receptor activity. Predicted to contribute to cytokine receptor activity. Acts upstream of or within vasculature development. Predicted to be located in membrane and microvillus. Predicted to be integral component of membrane. Predicted to be part of macrophage migration inhibitory factor receptor complex. Predicted to be active in basolateral plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See cd44a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (49882749..49893013, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (49609973..49620224, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 7 NC_007118.5 (51339738..51350030, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene peptidase domain containing associated with muscle regeneration 1a Neighboring gene solute carrier family 1 member 2a Neighboring gene APAF1 interacting protein Neighboring gene leucine rich repeat containing 4C, genome duplicate b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hyaluronic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vasculature development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    part_of macrophage migration inhibitory factor receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      49882749..49893013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001922456.6XP_001922491.1  CD44 antigen

      UniProtKB/TrEMBL
      E7F6T0
      Related
      ENSDARP00000110970.1, ENSDART00000126240.3
      Conserved Domains (1) summary
      pfam00193
      Location:33122
      Xlink; Extracellular link domain