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    LY86 lymphocyte antigen 86 [ Homo sapiens (human) ]

    Gene ID: 9450, updated on 12-Aug-2022

    Summary

    Official Symbol
    LY86provided by HGNC
    Official Full Name
    lymphocyte antigen 86provided by HGNC
    Primary source
    HGNC:HGNC:16837
    See related
    Ensembl:ENSG00000112799 MIM:605241; AllianceGenome:HGNC:16837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MD1; MD-1; MMD-1; dJ80N2.1
    Summary
    Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lymph node (RPKM 17.5), spleen (RPKM 16.2) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LY86 in Genome Data Viewer
    Location:
    6p25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (6588720..6654982)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (6457947..6524157)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (6588953..6655215)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LY86 antisense RNA 1 Neighboring gene small nuclear RNA activating complex polypeptide 5 pseudogene 1 Neighboring gene calponin 3 pseudogene 1 Neighboring gene uncharacterized LOC101928004 Neighboring gene uncharacterized LOC101928047 Neighboring gene uncharacterized LOC105374901

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
    EBI GWAS Catalog
    Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lymphocyte antigen 86
    Names
    MD-1, RP105-associated
    ly-86
    protein MD-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004271.4NP_004262.1  lymphocyte antigen 86 precursor

      See identical proteins and their annotated locations for NP_004262.1

      Status: VALIDATED

      Source sequence(s)
      BC038846, CD695164
      Consensus CDS
      CCDS4498.1
      UniProtKB/Swiss-Prot
      O95711, Q9UQC4
      Related
      ENSP00000230568.3, ENST00000230568.5
      Conserved Domains (1) summary
      cd00915
      Location:30159
      MD-1_MD-2; MD-1 and MD-2 are cofactors required for LPS signaling through cell surface receptors. MD-2 and its binding partner, Toll-like receptor 4 (TLR4), are essential for the innate immune responses of mammalian cells to bacterial lipopolysaccharide (LPS); MD-2 ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      6588720..6654982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      6457947..6524157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)