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    Spon2 spondin 2, extracellular matrix protein [ Mus musculus (house mouse) ]

    Gene ID: 100689, updated on 20-Jul-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice.

    Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice.
    Cheng XS, Huo YN, Fan YY, Xiao CX, Ouyang XM, Liang LY, Lin Y, Wu JF, Ren JL, Guleng B., Free PMC Article

    05/8/2021
    mindin binds with the integrin Mac-1 to promote macrophage phagocytosis through Syk activation and NF-kappaB p65 translocation.

    The pattern-recognition molecule mindin binds integrin Mac-1 to promote macrophage phagocytosis via Syk activation and NF-κB p65 translocation.
    Liu YS, Wang LF, Cheng XS, Huo YN, Ouyang XM, Liang LY, Lin Y, Wu JF, Ren JL, Guleng B., Free PMC Article

    07/18/2020
    Study identified the extracelular matrix protein mindin in the secretome of prostate adenocarcinoma cells and show that mindin overexpression in human and mouse TRAMP-C1-induced prostate tumors correlates with upregulated levels of bone-related genes in the tumorigenic prostate tissues. Mindin silencing decreased osteomimicry in adenocarcinoma cells and in the prostate tumor mice model.

    The secreted matrix protein mindin increases prostate tumor progression and tumor-bone crosstalk via ERK 1/2 regulation.
    Ardura JA, Gutiérrez-Rojas I, Álvarez-Carrión L, Rodríguez-Ramos MR, Pozuelo JM, Alonso V.

    05/16/2020
    Mindin is a novel modulator of hepatic I/R injury through regulating inflammatory responses, as well as hepatocyte apoptosis and proliferation via inactivation of the Akt signaling pathway.

    Mindin deficiency protects the liver against ischemia/reperfusion injury.
    Sun P, Zhang P, Wang PX, Zhu LH, Du Y, Tian S, Zhu X, Li H.

    12/17/2016
    Mindin protects against vascular hyperplasia by suppression of abnormal VSMC proliferation, migration and phenotypic switching in an AKT-dependent manner.

    Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation.
    Zhu LH, Huang L, Zhang X, Zhang P, Zhang SM, Guan H, Zhang Y, Zhu XY, Tian S, Deng K, Li H.

    07/25/2015
    Spondin 2 regulates hepatic lipid metabolism and alleviates hepatic steatosis, obesity, inflammation, and insulin resistance via its interaction with PPARalpha.

    Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice.
    Zhu LH, Wang A, Luo P, Wang X, Jiang DS, Deng W, Zhang X, Wang T, Liu Y, Gao L, Zhang S, Zhang X, Zhang J, Li H.

    05/16/2015
    The data of this study demonstrated that mindin is a critical mediator of ischemic brain injury in an experimental stroke model.

    Mindin is a critical mediator of ischemic brain injury in an experimental stroke model.
    Wang L, Lu Y, Zhang X, Zhang Y, Jiang D, Dong X, Deng S, Yang L, Guan Y, Zhu L, Zhou Y, Zhang X, Li H.

    11/30/2013
    Data show that mindin, as an intrinsic cardioprotective factor, prevents maladaptive remodelling and the transition to heart failure by blocking AKT/GSK3beta signalling.

    Disruption of mindin exacerbates cardiac hypertrophy and fibrosis.
    Bian ZY, Wei X, Deng S, Tang QZ, Feng J, Zhang Y, Liu C, Jiang DS, Yan L, Zhang LF, Chen M, Fassett J, Chen Y, He YW, Yang Q, Liu PP, Li H., Free PMC Article

    11/17/2012
    Mindin expression is upregulated during intestinal inflammation and may induce NF-kappaBp65 promoter activation in a TLR-9 mediated manner.

    Mindin is upregulated during colitis and may activate NF-kappaB in a TLR-9 mediated manner.
    Guleng B, Lian YM, Ren JL., Free PMC Article

    05/31/2010
    Mindin is a pattern-recognition molecule for microbial pathogens.

    The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.
    He YW, Li H, Zhang J, Hsu CL, Lin E, Zhang N, Guo J, Forbush KA, Bevan MJ.

    01/21/2010
    mindin participates in integrin-dependent trafficking of eosinophils and can contribute to the severity of allergic airways disease.

    The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace.
    Li Z, Garantziotis S, Jia W, Potts EN, Lalani S, Liu Z, He YW, Foster WM, Hollingsworth JW., Free PMC Article

    01/21/2010
    The structure of the F-spondin domain of mindin was determined at 1.8-A resolution.

    Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule.
    Li Y, Cao C, Jia W, Yu L, Mo M, Wang Q, Huang Y, Lim JM, Ishihara M, Wells L, Azadi P, Robinson H, He YW, Zhang L, Mariuzza RA., Free PMC Article

    01/21/2010
    mindin plays an essential role in the host innate immune response to influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influenza infection.

    Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses.
    Jia W, Li H, He YW.

    01/21/2010
    Mindin-integrin interactions play a key role in regulating Rho GTPase expression in DCs and DC priming of T lymphocytes.

    Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin.
    Li H, Oliver T, Jia W, He YW., Free PMC Article

    01/21/2010
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