| TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy. | TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy.
Zhang J, Li Y, Chen J, Huang T, Lin J, Pi Y, Hao H, Wang D, Liang X, Fu S, Yu J., Free PMC Article | 04/18/2024 |
| Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma. | Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma.
Dong Z, Zhang G, Lu J, Guo Y, Liang J, Shen S, Guo W. | 04/17/2023 |
| Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway. | Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway.
Wang D, Li Y, Sui S, Cai M, Dong K, Wang P, Liang X, Fu S, Yu J., Free PMC Article | 01/21/2023 |
| Identification of miR253p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer. | Identification of miR‑25‑3p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer.
Zhao T, Meng W, Chin Y, Gao L, Yang X, Sun S, Pan X, He L., Free PMC Article | 05/15/2021 |
| TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer. | TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer.
Bai Y, Qiao L, Xie N, Li Y, Nie Y, Pan Y, Shi Y, Wang J, Liu N., Free PMC Article | 04/24/2021 |
| LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis. | LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis.
Wang R, Huang Z, Qian C, Wang M, Zheng Y, Jiang R, Yu C. | 11/28/2020 |
| The downregulation of DAL-1 and TOB1 expression is associated with shorter survival of gastric cancer patients and may be considered potential novel markers for predicting the outcomes of patients with gastric cancer | Decreased expression levels of DAL-1 and TOB1 are associated with clinicopathological features and poor prognosis in gastric cancer.
Guo H, Zhang R, Afrifa J, Wang Y, Yu J. | 01/11/2020 |
| TOB1 was found to be directly targeted by miR-371a-3p, in which TOB1 was down-regulated by miR-371a-3p in gastric cancer (GC). Most importantly, results showed that TOB1 plays a tumor-suppressive role in GC cells, and it is required for the miR-371a-3p's oncogenic activities in GC cells. | MicroRNA-371a-3p promotes progression of gastric cancer by targeting TOB1.
Guo H, Ji F, Zhao X, Yang X, He J, Huang L, Zhang Y. | 11/9/2019 |
| Our findings provide important insights into a previously unrecognized oncogenic role of Tob1 in colon cancer and suggest that Tob1 is an adverse prognostic factor and therapeutic target for colon cancer. | High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.
Li D, Xiao L, Ge Y, Fu Y, Zhang W, Cao H, Chen B, Wang H, Zhan YY, Hu T., Free PMC Article | 04/27/2019 |
| MiR-590 targets Tob1 that is significantly decreased in patients with multiple sclerosis. | MicroRNA-590 promotes pathogenic Th17 cell differentiation through targeting Tob1 and is associated with multiple sclerosis.
Liu Q, Gao Q, Zhang Y, Li Z, Mei X. | 10/21/2017 |
| The dual-luciferase reporter assay also confirmed that miR-25 harbored the A allele which caused an incapacitation of binding at the TOB1. In conclusion, rs41274221 in miR-25 was a subgroup which may protect the patients from further growth and metastasis of gastric cancer and might serve as a novel biomarker for the disease | The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer.
Zhou J, Zhou J, Wang W, Li W, Wu L, Li G, Shi J, Zhou S. | 02/4/2017 |
| A novel role for TOB1 in mediating survival of estrogen-independent breast cancers. | Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation.
Zhang YW, Nasto RE, Varghese R, Jablonski SA, Serebriiskii IG, Surana R, Calvert VS, Bebu I, Murray J, Jin L, Johnson M, Riggins R, Ressom H, Petricoin E, Clarke R, Golemis EA, Weiner LM., Free PMC Article | 09/3/2016 |
| Reduced TOB1 expression in gastric adenocarcinoma is associated with the extent of differentiation and the TNM stage of gastric cancer. | Clinicopathological significance of cytoplasmic transducer of ErbB2. 1 expression in gastric cancer.
Zhang SQ, Sun KK, Wu XY, Zhong N, Zhao H, Li DC. | 01/16/2016 |
| miR-25 promotes GC progression by directly downregulating TOB1 expression, and may be a noninvasive biomarker for the prognosis of GC patients. | MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival.
Li BS, Zuo QF, Zhao YL, Xiao B, Zhuang Y, Mao XH, Wu C, Yang SM, Zeng H, Zou QM, Guo G. | 08/1/2015 |
| arsenite-induced oxidative stress inhibits deadenylation of mRNA primarily through downregulation of Tob and Pan3, both of which mediate the recruitment of deadenylases to mRNA | Arsenite inhibits mRNA deadenylation through proteolytic degradation of Tob and Pan3.
Yamagishi R, Hosoda N, Hoshino S. | 02/14/2015 |
| Tob is a key factor in the regulation of c-myc gene expression, which is essential for cell growth. | Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB.
Ogami K, Hosoda N, Funakoshi Y, Hoshino S. | 03/8/2014 |
| TOB1 demonstrated a radioprotective function in the immortalized normal human bronchial epithelial cell line. | Overexpression of TOB1 confers radioprotection to bronchial epithelial cells through the MAPK/ERK pathway.
Che J, Lu YW, Sun KK, Feng C, Dong AJ, Jiao Y. | 03/1/2014 |
| TOB1 modulates the radiosensitivity of lung cancer cells via the MAPK/ERK signaling pathway. | Enhanced radiosensitivity of NSCLC cells by transducer of erbB2.1 (TOB1) through modulation of the MAPK/ERK pathway.
Sun KK, Zhong N, Yang Y, Zhao L, Jiao Y. | 11/2/2013 |
| Cdc7 phosphorylates and interacts with Tob to inhibit the Cul4-DDB1(Cdt2)-dependent Tob degradation. | Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.
Suzuki T, Tsuzuku J, Hayashi A, Shiomi Y, Iwanari H, Mochizuki Y, Hamakubo T, Kodama T, Nishitani H, Masai H, Yamamoto T., Free PMC Article | 03/2/2013 |
| study demonstrates that the overexpression of Tob1 inhibits gastric cancer progression by activating Smad4- and inhibiting betacatenin-mediated signaling pathways | Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting β‑catenin signaling.
Kundu J, Wahab SM, Kundu JK, Choi YL, Erkin OC, Lee HS, Park SG, Shin YK., Free PMC Article | 01/26/2013 |
| TOB1 overexpression not only increased the expression of the phosphatase and tensin homolog (PTEN), an important tumor suppressor, but also regulated the downstream effectors in the PI3K/PTEN signaling pathway, including Akt, ERK1/2, etc. | Suppression of human lung cancer cell proliferation and metastasis in vitro by the transducer of ErbB-2.1 (TOB1).
Jiao Y, Sun KK, Zhao L, Xu JY, Wang LL, Fan SJ., Free PMC Article | 05/26/2012 |
| The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked. | Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.
Ezzeddine N, Chen CY, Shyu AB., Free PMC Article | 04/14/2012 |
| Silencing of HIC1 and TOB1 expression is a common occurrence in gastric cancer and may contribute to the development and progression of the disease. | Identification of novel subregions of LOH in gastric cancer and analysis of the HIC1 and TOB1 tumor suppressor genes in these subregions.
Yu J, Liu P, Cui X, Sui Y, Ji G, Guan R, Sun D, Ji W, Liu F, Liu A, Zhao Y, Yu Y, Jin Y, Bai J, Geng J, Xue Y, Qi J, Lee KY, Fu S., Free PMC Article | 12/31/2011 |
| Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). | Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles.
Bauerschlag DO, Ammerpohl O, Bräutigam K, Schem C, Lin Q, Weigel MT, Hilpert F, Arnold N, Maass N, Meinhold-Heerlein I, Wagner W. | 10/1/2011 |
| Together, these results indicate that Tob mediates the recruitment of Caf1 to the target of CPEB3 and elicits deadenylation and decay of the mRNA. | Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.
Hosoda N, Funakoshi Y, Hirasawa M, Yamagishi R, Asano Y, Miyagawa R, Ogami K, Tsujimoto M, Hoshino S., Free PMC Article | 06/18/2011 |