| ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/beta-Catenin Signaling Pathway. | ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway.
Zhu CC, Sun HL, Long TF, Lyu YY, Liu JL, Ni GT. | 05/1/2024 |
| CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2alpha and upregulation of tumor suppressor RBM5. | CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2α and upregulation of tumor suppressor RBM5.
Jin B, Wang M, Sun Y, Lee PAH, Zhang X, Lu Y, Zhao B., Free PMC Article | 04/4/2024 |
| RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9. | RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9.
Zhang M, Hyle J, Chen X, Xin Y, Jin Y, Zhang J, Yang X, Chen X, Wright S, Liu Z, Rosikiewicz W, Xu B, He L, Liu H, Ping N, Wu D, Wen F, Li C, Xu P., Free PMC Article | 01/27/2024 |
| Elucidating the role of RBM5 in osteoclastogenesis: a novel potential therapeutic target for osteoporosis. | Elucidating the role of RBM5 in osteoclastogenesis: a novel potential therapeutic target for osteoporosis.
Zhang Y, Chen X, Xiao Y, Mei Y, Yang T, Li D, Wang X, Yang H, Huang D, Hao D., Free PMC Article | 12/6/2023 |
| RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p. | RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p.
Bai T, Liu N. | 04/6/2023 |
| A bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5 granules. | A bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5 granules.
Pourpre R, Lakisic G, Desgranges E, Cossart P, Pagliuso A, Bierne H., Free PMC Article | 12/31/2022 |
| A de novo paradigm for male infertility. | A de novo paradigm for male infertility.
Oud MS, Smits RM, Smith HE, Mastrorosa FK, Holt GS, Houston BJ, de Vries PF, Alobaidi BKS, Batty LE, Ismail H, Greenwood J, Sheth H, Mikulasova A, Astuti GDN, Gilissen C, McEleny K, Turner H, Coxhead J, Cockell S, Braat DDM, Fleischer K, D'Hauwers KWM, Schaafsma E, Genetics of Male Infertility Initiative (GEMINI) consortium, Nagirnaja L, Conrad DF, Friedrich C, Kliesch S, Aston KI, Riera-Escamilla A, Krausz C, Gonzaga-Jauregui C, Santibanez-Koref M, Elliott DJ, Vissers LELM, Tüttelmann F, O'Bryan MK, Ramos L, Xavier MJ, van der Heijden GW, Veltman JA., Free PMC Article | 02/12/2022 |
| Circular circPSMC3 inhibits hepatocellular carcinoma migration and invasion by upregulating RBM5. | Circular circPSMC3 inhibits hepatocellular carcinoma migration and invasion by upregulating RBM5.
Tang B, Wang Y, Zhu F, Li H, Liu L, Chen Y, Zhou Y. | 08/7/2021 |
| RBM5 Acts as Tumor Suppressor in Medulloblastoma through Regulating Wnt/beta-Catenin Signaling. | RBM5 Acts as Tumor Suppressor in Medulloblastoma through Regulating Wnt/β-Catenin Signaling.
Yu J, Ji G, Shi W, Zhao R, Shen W, Zheng J, Li H, Jiang F. | 03/20/2021 |
| Conformational Dynamics from Ambiguous Zinc Coordination in the RanBP2-Type Zinc Finger of RBM5. | Conformational Dynamics from Ambiguous Zinc Coordination in the RanBP2-Type Zinc Finger of RBM5.
Soni K, Martínez-Lumbreras S, Sattler M. | 01/2/2021 |
| RBM5 expression was significantly down-regulated in bladder cancer tissues. Downrergulated RBM5 inhibits bladder cancer cell apoptosis via miR-432-5p/beta-catenin signaling. | Down-regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR-432-5p/β-catenin feedback loop.
Zhang YP, Liu KL, Wang YX, Yang Z, Han ZW, Lu BS, Qi JC, Yin YW, Teng ZH, Chang XL, Li JD, Xin H, Li W. | 06/6/2020 |
| RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD). | Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay.
Sun Y, Bao Y, Han W, Song F, Shen X, Zhao J, Zuo J, Saffen D, Chen W, Wang Z, You X, Wang Y., Free PMC Article | 10/28/2017 |
| results provide evidence that RBM10 expression, in RBM5-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 expression in clinical samples may therefore hold prognostic and/or potentially predictive value | RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.
Loiselle JJ, Roy JG, Sutherland LC., Free PMC Article | 10/7/2017 |
| the mechanism of action of RBM5-AS1 in the WNT pathway via physical interactions with beta-catenin, helping organize transcriptional complexes that sustain colon cancer-initiating cells function. | RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells.
Di Cecilia S, Zhang F, Sancho A, Li S, Aguiló F, Sun Y, Rengasamy M, Zhang W, Del Vecchio L, Salvatore F, Walsh MJ., Free PMC Article | 08/5/2017 |
| Low RBM5 expression was significantly associated with gliomas. | RBM5 inhibits tumorigenesis of gliomas through inhibition of Wnt/β-catenin signaling and induction of apoptosis.
Jiang Y, Sheng H, Meng L, Yue H, Li B, Zhang A, Dong Y, Liu Y., Free PMC Article | 06/24/2017 |
| RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer | Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer.
Kobayashi T, Ishida J, Shimizu Y, Kawakami H, Suda G, Muranaka T, Komatsu Y, Asaka M, Sakamoto N. | 04/8/2017 |
| Results show that RBM5 is downregulated in smoke induced tumor; its overexpression inhibits tumor growth through cell cycle arrest and induction of apoptosis suggesting the importance of RBM5 in the pathogenesis of smoking-related cancer. | RNA-binding motif protein 5 inhibits the proliferation of cigarette smoke-transformed BEAS-2B cells through cell cycle arrest and apoptosis.
Lv XJ, Du YW, Hao YQ, Su ZZ, Zhang L, Zhao LJ, Zhang J. | 12/24/2016 |
| ICG-001 had no apparent effect on the RBM5 levels. | RNA-binding motif protein 5 negatively regulates the activity of Wnt/β-catenin signaling in cigarette smoke-induced alveolar epithelial injury.
Hao YQ, Su ZZ, Lv XJ, Li P, Gao P, Wang C, Bai Y, Zhang J. | 12/19/2015 |
| RBM5 knockdown in human neuronal cells decreases caspase activation by staurosporine. | The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice.
Jackson TC, Du L, Janesko-Feldman K, Vagni VA, Dezfulian C, Poloyac SM, Jackson EK, Clark RS, Kochanek PM., Free PMC Article | 06/20/2015 |
| Antagonizes the effects of RBM5, RBM6, and RBM10 in cell colony formation. | RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.
Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J. | 04/19/2014 |
| Loss of RBM5 expression is associated with lung adenocarcinoma. | Tumor suppressor gene RBM5 delivered by attenuated Salmonella inhibits lung adenocarcinoma through diverse apoptotic signaling pathways.
Shao C, Yang B, Zhao L, Wang S, Zhang J, Wang K., Free PMC Article | 12/21/2013 |
| expression of RBM5 protein was significantly decreased in cancerous prostatic tissues compared to the normal tissues | 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis.
Zhao L, Li R, Shao C, Li P, Liu J, Wang K., Free PMC Article | 08/3/2013 |
| RBM5 can inhibit the growth of lung cancer cells and induce apoptosis both in vitro and in vivo. | The tumor suppressor gene RBM5 inhibits lung adenocarcinoma cell growth and induces apoptosis.
Shao C, Zhao L, Wang K, Xu W, Zhang J, Yang B., Free PMC Article | 06/22/2013 |
| Expression of RBM5 mRNA and protein was negatively correlated with expression of EGFR and KRAS mRNA and protein in NSCLC tissues. | Differential expression of RBM5, EGFR and KRAS mRNA and protein in non-small cell lung cancer tissues.
Liang H, Zhang J, Shao C, Zhao L, Xu W, Sutherland LC, Wang K., Free PMC Article | 03/2/2013 |
| RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract. | RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract.
Jin W, Niu Z, Xu D, Li X. | 01/5/2013 |