| ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway. | ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.
Zheng D, Wei Z, Zhang C, Liu W, Gong C, Wu F, Guo W., Free PMC Article | 05/7/2024 |
| Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1. | Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
Zhu J, Peng Z, Tian X, Wu T, Sun A, Yang W, Lin Q. | 06/28/2023 |
| Host factor TNK2 is required for influenza virus infection. | Host factor TNK2 is required for influenza virus infection.
Zhou A, Zhang W, Wang B. | 05/23/2023 |
| ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer. | ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
Hodder S, Fox M, Binti Ahmad Mokhtar AM, Mott HR, Owen D., Free PMC Article | 05/18/2023 |
| Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1. | Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
Kan Y, Paung Y, Seeliger MA, Miller WT., Free PMC Article | 04/12/2023 |
| Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk. | Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
Kan Y, Paung Y, Kim Y, Seeliger MA, Miller WT., Free PMC Article | 03/26/2023 |
| Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region. | Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.
Kan Y, Miller WT., Free PMC Article | 11/26/2022 |
| Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK. | Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.
Clayton NS, Fox M, Vicenté-Garcia JJ, Schroeder CM, Littlewood TD, Wilde JI, Krishnan K, Brown MJB, Crafter C, Mott HR, Owen D., Free PMC Article | 07/2/2022 |
| Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition. | Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition.
Ji Z, Njauw CN, Guhan S, Kumar R, Reddy B, Rajadurai A, Flaherty K, Tsao H. | 11/22/2021 |
| TNK2 promoted esophageal cancer progression via activating egfr-akt signaling. | TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.
Zhang A, Zhang R, Yang Z, Tian R., Free PMC Article | 11/6/2021 |
| Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer. | Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer.
Zhu J, Liu Y, Zhao M, Cao K, Ma J, Peng S., Free PMC Article | 08/21/2021 |
| Targeted inhibition of ACK1 can inhibit the proliferation of hepatocellular carcinoma cells through the PTEN/AKT/mTOR pathway. | Targeted inhibition of ACK1 can inhibit the proliferation of hepatocellular carcinoma cells through the PTEN/AKT/mTOR pathway.
Wang B, Song K, Chen L, Su H, Gao L, Liu J, Huang A. | 05/22/2021 |
| Knockdown of activated Cdc42-associated kinase inhibits human extravillous trophoblast migration and invasion and decreases protein expression of pho-Akt and matrix metalloproteinase. | Knockdown of activated Cdc42-associated kinase inhibits human extravillous trophoblast migration and invasion and decreases protein expression of pho-Akt and matrix metalloproteinase.
Liu Y, Shan N, Yuan Y, Tan B, He C, Tong C, Qi H. | 01/2/2021 |
| Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen. | Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen.
De Silva D, Zhang Z, Liu Y, Parker JS, Xu C, Cai L, Wang GG, Earp HS, Whang YE., Free PMC Article | 11/21/2020 |
| Together, these data support a model wherein TNK2, WASL, and NCK1 comprise a pathway important for the entry of multiple picornaviruses. | Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1.
Jiang H, Leung C, Tahan S, Wang D., Free PMC Article | 05/9/2020 |
| in this review, we will be summarizing the structural characteristics, activation, and regulation of ACK1 in breast cancer, aiming to deeply understand the functional and mechanistic role of ACK1 and provide novel therapeutic strategies for breast cancer treatment. | Research Progress of the Functional Role of ACK1 in Breast Cancer.
Liu X, Wang X, Li L, Han B., Free PMC Article | 04/11/2020 |
| ACK1 activated AKT and Src enhanced nuclear factor-small ka, CyrillicB (NF-small ka, CyrillicB) activity, suggesting a correlation between NF-small ka, CyrillicB signaling and TNF-alpha-mediated apoptosis in Caco-2 cells. Results demonstrate that ACK1 plays an important role in modulating TNF-alpha-induced aberrant cell proliferation and apoptosis, mediated in part by ACK1 activation. | A role for the non-receptor tyrosine kinase ACK1 in TNF-alpha-mediated apoptosis and proliferation in human intestinal epithelial caco-2 cells.
Zhao X, Lv C, Chen S, Zhi F. | 11/9/2019 |
| blockade of ACK1/TNK2 could be a new therapeutic modality to target recalcitrant Prostate cancer stem-like cells. | Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells.
Mahajan NP, Coppola D, Kim J, Lawrence HR, Lawrence NJ, Mahajan K., Free PMC Article | 12/22/2018 |
| HSP90 is an upstream regulator of the ACK1-dependent phosphorylation of STAT1 and STAT3. | HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3.
Mahendrarajah N, Borisova ME, Reichardt S, Godmann M, Sellmer A, Mahboobi S, Haitel A, Schmid K, Kenner L, Heinzel T, Beli P, Krämer OH. | 06/9/2018 |
| we demonstrate that amplification of ACK1 promotes gastric tumorigenesis by inducing an ECD-dependent ubiquitination degradation of p53 | Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation.
Xu SH, Huang JZ, Chen M, Zeng M, Zou FY, Chen D, Yan GR., Free PMC Article | 09/23/2017 |
| These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding. | A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK.
Tetley GJN, Mott HR, Cooley RN, Owen D., Free PMC Article | 07/15/2017 |
| miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT-MMP2-MMP9 pathway. | miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT/MMPs pathway.
Liu Z, Liu Z, Zhang Y, Li Y, Liu B, Zhang K. | 06/24/2017 |
| findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells. | Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.
Thaker YR, Recino A, Raab M, Jabeen A, Wallberg M, Fernandez N, Rudd CE., Free PMC Article | 04/29/2017 |
| ACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms. | Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms.
Lv C, Zhao X, Gu H, Huang L, Zhou S, Zhi F., Free PMC Article | 04/1/2017 |
| Ack1 overexpression promotes metastasis in hepatocellular carcinoma. | Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma.
Lei X, Li YF, Chen GD, Ou DP, Qiu XX, Zuo CH, Yang LY., Free PMC Article | 10/8/2016 |