| Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses. | Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses.
Inglebert Y, Wu PY, Tourbina-Kolomiets J, Dang CL, McKinney RA., Free PMC Article | 04/5/2024 |
| Synaptopodin Regulates Denervation-Induced Plasticity at Hippocampal Mossy Fiber Synapses. | Synaptopodin Regulates Denervation-Induced Plasticity at Hippocampal Mossy Fiber Synapses.
Kruse P, Brandes G, Hemeling H, Huang Z, Wrede C, Hegermann J, Vlachos A, Lenz M., Free PMC Article | 02/9/2024 |
| Autism-related KLHL17 and SYNPO act in concert to control activity-dependent dendritic spine enlargement and the spine apparatus. | Autism-related KLHL17 and SYNPO act in concert to control activity-dependent dendritic spine enlargement and the spine apparatus.
Hu HT, Lin YJ, Wang UT, Lee SP, Liou YH, Chen BC, Hsueh YP., Free PMC Article | 09/14/2023 |
| All-trans retinoic acid induces synaptopodin-dependent metaplasticity in mouse dentate granule cells. | All-trans retinoic acid induces synaptopodin-dependent metaplasticity in mouse dentate granule cells.
Lenz M, Eichler A, Kruse P, Muellerleile J, Deller T, Jedlicka P, Vlachos A., Free PMC Article | 11/22/2021 |
| Granule Cell Ensembles in Mouse Dentate Gyrus Rapidly Upregulate the Plasticity-Related Protein Synaptopodin after Exploration Behavior. | Granule Cell Ensembles in Mouse Dentate Gyrus Rapidly Upregulate the Plasticity-Related Protein Synaptopodin after Exploration Behavior.
Paul MH, Choi M, Schlaudraff J, Deller T, Del Turco D., Free PMC Article | 08/21/2021 |
| Myosin V regulates synaptopodin clustering and localization in the dendrites of hippocampal neurons. | Myosin V regulates synaptopodin clustering and localization in the dendrites of hippocampal neurons.
Konietzny A, González-Gallego J, Bär J, Perez-Alvarez A, Drakew A, Demmers JAA, Dekkers DHW, Hammer JA 3rd, Frotscher M, Oertner TG, Wagner W, Kneussel M, Mikhaylova M., Free PMC Article | 07/11/2020 |
| Study indicates that a reduction in the expression of synaptopodin ameliorates Alzheimer's Disease-associated phenotype in 3xTg mice. | Synaptopodin Deficiency Ameliorates Symptoms in the 3xTg Mouse Model of Alzheimer's Disease.
Aloni E, Oni-Biton E, Tsoory M, Moallem DH, Segal M., Free PMC Article | 06/20/2020 |
| These findings indicate that NEFH is expressed in podocytes during the disease course and that it prevents the reduction in synaptopodin expression and detachment of podocytes. | Neurofilament heavy polypeptide protects against reduction in synaptopodin expression and prevents podocyte detachment.
Wang J, Hidaka T, Sasaki Y, Tanaka E, Takagi M, Shibata T, Kubo A, Trejo JAO, Wang L, Asanuma K, Tomino Y., Free PMC Article | 11/2/2019 |
| synaptopodin-deficient mice lacking the cisternal organelle showed AIS shortening in the dark | Structural Plasticity of Synaptopodin in the Axon Initial Segment during Visual Cortex Development.
Schlüter A, Del Turco D, Deller T, Gutzmann A, Schultz C, Engelhardt M. | 06/23/2018 |
| Results link synaptopodin (SP) with ryanodine receptors, in that ryanodine is able to convert short-term potentiation to long-term potentiation under our testing conditions only in ventral hippocampus, and only in the presence of SP in this region of the hippocampus. | Ryanodine-mediated conversion of STP to LTP is lacking in synaptopodin-deficient mice.
Grigoryan G, Segal M. | 10/7/2017 |
| miR-206 was up-regulated in Adriamycin nephropathy mice, which led to severe podocyte injury and inhibited the expression of WT1 and synaptopodin. In vitro, over expression of miR-206 induced WT1 and synaptopodin degradation and actin rearrangement, initiating a catastrophic collapse of the entire podocyte-stabilizing system. | MicroRNA-206 and its down-regulation of Wilms'Tumor-1 dictate podocyte health in adriamycin-induced nephropathy.
Guo N, Guo J, Su D. | 04/15/2017 |
| WAVE1 phosphorylation in podocytes. Synaptopodin is a well-characterized target of CsA. WAVE1 overexpression and synaptopodin knockdown experiments directly demonstrated that WAVE1 expression is not dependent on synaptopodin expression, and vice versa | Cyclosporine A protects podocytes by regulating WAVE1 phosphorylation.
Li X, Ding F, Wang S, Li B, Ding J., Free PMC Article | 10/8/2016 |
| synaptopodin has an essential, calcium store-related role in regulating synaptic plasticity in cultured hippocampal neurons | Synaptopodin regulates spine plasticity: mediation by calcium stores.
Korkotian E, Frotscher M, Segal M., Free PMC Article | 10/18/2014 |
| Our results identify synaptopodin as a substrate of PKA in hippocampal neurons and point to an essential role for synaptopodin in activity-dependent regulation of dendritic spine dynamics and synaptic plasticity in postnatal brain development. | Essential role for synaptopodin in dendritic spine plasticity of the developing hippocampus.
Zhang XL, Pöschel B, Faul C, Upreti C, Stanton PK, Mundel P., Free PMC Article | 10/19/2013 |
| Synaptopodin has an important role in homeostatic synaptic plasticity | Synaptopodin regulates denervation-induced homeostatic synaptic plasticity.
Vlachos A, Ikenberg B, Lenz M, Becker D, Reifenberg K, Bas-Orth C, Deller T., Free PMC Article | 07/27/2013 |
| Together, these results indicate that alpha-actinin and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS. | Colocalization of α-actinin and synaptopodin in the pyramidal cell axon initial segment.
Sánchez-Ponce D, Blázquez-Llorca L, DeFelipe J, Garrido JJ, Muñoz A. | 11/17/2012 |
| Synpatopodin may play an important role in the changes of PSD-95 and NR1 protein levels and other synaptic alterations that are induced by corticosterone | Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain.
Cohen JW, Louneva N, Han LY, Hodes GE, Wilson RS, Bennett DA, Lucki I, Arnold SE., Free PMC Article | 10/22/2011 |
| HGF protects podocytes from a loss of nephrin, at least in part, through maintaining synaptopodin in nephritic mice with albuminuria. | Preservations of nephrin and synaptopodin by recombinant hepatocyte growth factor in podocytes for the attenuations of foot process injury and albuminuria in nephritic mice.
Kato T, Mizuno S, Nakamura T. | 06/18/2011 |
| In this review, hippocampal neurons in SP-knockout mice lack a dendritic spine apparatus and express lower long term potential, probably playing a role in synaptic plasticity and linked mechanistically to synaptic functions. | The spine apparatus, synaptopodin, and dendritic spine plasticity.
Segal M, Vlachos A, Korkotian E. | 12/11/2010 |
| Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments. | Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments.
Kim EY, Suh JM, Chiu YH, Dryer SE., Free PMC Article | 09/27/2010 |
| The result of this study demonstrate that synaptopodin is an essential component of the cisternal organelle of axons and of the dendritic spine apparatus, two organelles that are structurally and molecularly related. | Loss of the cisternal organelle in the axon initial segment of cortical neurons in synaptopodin-deficient mice.
Bas Orth C, Schultz C, Müller CM, Frotscher M, Deller T. | 01/21/2010 |
| Synaptopodin directly binds to IRSp53 and suppresses Cdc42:IRSp53:Mena-initiated filopodia formation by blocking the binding of Cdc42 and Mena to IRSp53. | Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes.
Yanagida-Asanuma E, Asanuma K, Kim K, Donnelly M, Young Choi H, Hyung Chang J, Suetsugu S, Tomino Y, Takenawa T, Faul C, Mundel P., Free PMC Article | 01/21/2010 |
| We found synaptopodin expression in primary sensory neurons of craniospinal ganglia. | Synaptopodin and 4 novel genes identified in primary sensory neurons.
Verpoorten N, Verhoeven K, Weckx S, Jacobs A, Serneels S, Del Favero J, Ceuterick C, Van Bockstaele DR, Berneman ZN, Van den Bosch L, Robberecht W, Nobbio L, Schenone A, Dessaud E, deLapeyrière O, Huylebroeck D, Zwijsen A, De Jonghe P, Timmerman V. | 01/21/2010 |
| CD2AP, Fyn, and synaptopodin have roles in development of focal segmental glomerulosclerosis in a mouse model | Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.
Huber TB, Kwoh C, Wu H, Asanuma K, Gödel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS., Free PMC Article | 01/21/2010 |
| Studies in mice have shown that sFlt-1 may play a role in inducing proteinuria by neutralizing vascular endothelial growth factor (VEGF) and suppressing nephrin and synaptopodin. | Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia.
Garovic VD, Wagner SJ, Petrovic LM, Gray CE, Hall P, Sugimoto H, Kalluri R, Grande JP. | 01/21/2010 |