| Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation. | Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation.
Singh BK, Yokoyama Y, Tanaka Y, Laczkó D, Deshpande DA, Kambayashi T. | 12/6/2023 |
| Diacylglycerol kinase zeta limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes. | Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes.
Arranz-Nicolás J, Martin-Salgado M, Rodríguez-Rodríguez C, Liébana R, Moreno-Ortiz MC, Leitner J, Steinberger P, Ávila-Flores A, Merida I., Free PMC Article | 09/18/2021 |
| DGK alpha and zeta Activities Control TH1 and TH17 Cell Differentiation. | DGK α and ζ Activities Control T(H)1 and T(H)17 Cell Differentiation.
Yang J, Wang HX, Xie J, Li L, Wang J, Wan ECK, Zhong XP., Free PMC Article | 10/24/2020 |
| Diacylglycerol kinase zeta promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms. | Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.
Singh BK, Lu W, Schmidt Paustian AM, Ge MQ, Koziol-White CJ, Flayer CH, Killingbeck SS, Wang N, Dong X, Riese MJ, Deshpande DA, Panettieri RA Jr, Haczku A, Kambayashi T., Free PMC Article | 08/15/2020 |
| The Dgkzeta induction in arthritic conditions perpetuates systemic inflammatory responses mediated by macrophages and highlight a potential role of Dgkzeta-DAG/phosphatidic acid axis as a modulator of inflammatory cytokine production in sJIA and CSS. | Diacylglycerol Kinase ζ Regulates Macrophage Responses in Juvenile Arthritis and Cytokine Storm Syndrome Mouse Models.
Mahajan S, Mellins ED, Faccio R., Free PMC Article | 08/1/2020 |
| results implicate DGKzeta as a novel negative regulator of GPVI-mediated platelet activation that plays an important role in regulating thrombus formation in vivo. | Diacylglycerol kinase ζ is a negative regulator of GPVI-mediated platelet activation.
Moroi AJ, Zwifelhofer NM, Riese MJ, Newman DK, Newman PJ., Free PMC Article | 07/25/2020 |
| Loss of DGK zeta expression is associated with muscle atrophy. | A DGKζ-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling.
You JS, Dooley MS, Kim CR, Kim EJ, Xu W, Goodman CA, Hornberger TA., Free PMC Article | 10/19/2019 |
| the results demonstrate that DGKzeta plays a sentinel role in p53 expression at the cellular and organismal levels after DNA damaging stress conditions. | DGKζ ablation engenders upregulation of p53 level in the spleen upon whole-body ionizing radiation.
Tanaka T, Iseki K, Tanaka K, Nakano T, Iino M, Goto K. | 09/14/2019 |
| DGKzeta deficiency protects against peripheral insulin resistance and improves energy metabolism. | DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism.
Benziane B, Borg ML, Tom RZ, Riedl I, Massart J, Björnholm M, Gilbert M, Chibalin AV, Zierath JR., Free PMC Article | 07/21/2018 |
| DGKzeta prevents GLUT4 translocation in the absence of insulin. DGKzeta dissociated from IRS-1 by insulin stimulation enhances GLUT4 translocation through PIP5K1alpha activity | A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes.
Liu T, Yu B, Kakino M, Fujimoto H, Ando Y, Hakuno F, Takahashi SI., Free PMC Article | 04/14/2018 |
| Our studies identify a previously unrecognized DGKzeta contribution as a negative regulator of the crosstalk between phospholipase C-gamma- and phosphoinositide 3-kinase-regulated pathways. | Predominant contribution of DGKζ over DGKα in the control of PKC/PDK-1-regulated functions in T cells.
Ávila-Flores A, Arranz-Nicolás J, Andrada E, Soutar D, Mérida I. | 03/31/2018 |
| Our results demonstrate that, in addition to its known role in limiting canonical antigen-mediated activation of cytotoxic function, DGKzeta negatively regulates IL-2/IL-15-dependent expansion of innate-like cytotoxic CD8+ T cells. These studies add to the growing evidence that targeting DAG metabolism through pharmacological manipulation of DGKzeta could be an important, yet-unexplored area for cancer immunotherapy. | Diacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8(+) T Cells with Broad Antitumor Capacity.
Andrada E, Liébana R, Merida I., Free PMC Article | 03/10/2018 |
| these data suggest that the activation of DGKzeta downstream of antigen recognition provides a mechanism that ensures the activation of PA-dependent signaling as a direct result of the strength of TCR-dependent DAG mobilization. | Diacylglycerol kinase ζ limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells.
Andrada E, Almena M, de Guinoa JS, Merino-Cortes SV, Liébana R, Arcos R, Carrasco S, Carrasco YR, Merida I. | 11/26/2017 |
| Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) | Diacylglycerol kinases in cancer.
Mérida I, Torres-Ayuso P, Ávila-Flores A, Arranz-Nicolás J, Andrada E, Tello-Lafoz M, Liébana R, Arcos R. | 11/18/2017 |
| We propose that enzymes that negatively regulate distal activating receptor signaling pathways such as DGKzeta represent novel targets for augmenting the therapeutic potential of NK cells. | Diacylglycerol Kinase ζ Is a Target To Enhance NK Cell Function.
Yang E, Singh BK, Paustian AM, Kambayashi T., Free PMC Article | 08/12/2017 |
| Downregulation of DGKzeta might be one factor predisposing a person to osteolytic bone destruction in pathological conditions. | DGKζ Downregulation Enhances Osteoclast Differentiation and Bone Resorption Activity Under Inflammatory Conditions.
Iwazaki K, Tanaka T, Hozumi Y, Okada M, Tsuchiya R, Iseki K, Topham MK, Kawamae K, Takagi M, Goto K. | 05/20/2017 |
| this is the first report implicating M-CSF/DGKzeta/DAG axis as a critical regulator of bone homeostasis via its actions on OC differentiation and c-Fos expression. | Diacylglycerol Kinase ζ (DGKζ) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts.
Zamani A, Decker C, Cremasco V, Hughes L, Novack DV, Faccio R., Free PMC Article | 06/28/2016 |
| another possible involvement of DGKzeta in the regulation of secretion of the terminal tubule cells, as well as its functional significance of its nuclear localization in the submandibular ganglion cells is discussed | Selective localization of diacylglycerol kinase (DGK)ζ in the terminal tubule cells in the submandibular glands of early postnatal mice.
Hipkaeo W, Chomphoo S, Pakkarato S, Sakaew W, Sawatpanich T, Hozumi Y, Polsan Y, Hipkaeo D, Goto K, Kondo H. | 05/7/2016 |
| This study demonstrated that Diacylglycerol Kinase zeta with Protein Kinase Calpha Is Required for Cerebellar Long-Term Depression | Functional and Physical Interaction of Diacylglycerol Kinase ζ with Protein Kinase Cα Is Required for Cerebellar Long-Term Depression.
Lee D, Yamamoto Y, Kim E, Tanaka-Yamamoto K., Free PMC Article | 03/5/2016 |
| The results suggest that DGKzeta cytoplasmic translocation in neurons under hypoxic stress is regulated by some mechanism which differs from that mediated by NAP1-like proteins. | Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress.
Takahashi N, Hozumi Y, Tanaka T, Okada M, Iseki K, Hayasaka K, Goto K. | 10/17/2015 |
| This study shows that DGKzeta knockdown facilitates degradation of IkappaB, followed by nuclear translocation of NF-kappaB p65 subunit. | Downregulation of diacylglycerol kinase ζ enhances activation of cytokine-induced NF-κB signaling pathway.
Tsuchiya R, Tanaka T, Hozumi Y, Nakano T, Okada M, Topham MK, Iino M, Goto K. | 04/25/2015 |
| It plays a role in pathogenesis of various disorders in the central nervous system. | The roles of diacylglycerol kinases in the central nervous system: review of genetic studies in mice.
Ishisaka M, Hara H. | 10/4/2014 |
| The zeta isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. | The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling.
Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA., Free PMC Article | 07/12/2014 |
| DGKzeta regulates the development of natural Treg cells by limiting the extent of activation of the ERK and c-Rel signaling pathways. | Diacylglycerol kinase ζ limits the generation of natural regulatory T cells.
Schmidt AM, Zou T, Joshi RP, Leichner TM, Pimentel MA, Sommers CL, Kambayashi T., Free PMC Article | 07/12/2014 |
| Data demonstrate that miR-34a is a negative regulator for DGKzeta and may play an important role in regulating T cell activation. | MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ.
Shin J, Xie D, Zhong XP., Free PMC Article | 06/7/2014 |