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    GPNMB glycoprotein nmb [ Homo sapiens (human) ]

    Gene ID: 10457, updated on 26-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Elevated Circulating Levels of Glycoprotein Non-Metastatic Melanoma Protein B as a Predictor of Gestational Diabetes Mellitus.

    Elevated Circulating Levels of Glycoprotein Non-Metastatic Melanoma Protein B as a Predictor of Gestational Diabetes Mellitus.
    Cao C, Wei L, Han Y, Wang Y, Zhang J, Zhang L, Kang Z, Zhang J.

    09/25/2021
    GPNMB promotes the progression of diffuse large B cell lymphoma via YAP1-mediated activation of the Wnt/beta-catenin signaling pathway.

    GPNMB promotes the progression of diffuse large B cell lymphoma via YAP1-mediated activation of the Wnt/β-catenin signaling pathway.
    Wang Z, Ran X, Qian S, Hou H, Dong M, Wu S, Ding M, Zhang Y, Zhang X, Zhang M, Chen Q.

    09/25/2021
    Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins.

    Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins.
    Chrystal PW, Footz T, Hodges ED, Jensen JA, Walter MA, Allison WT., Free PMC Article

    07/31/2021
    Intracerebroventricular Treatment with 2-Hydroxypropyl-beta-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice.

    Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice.
    Fukaura M, Ishitsuka Y, Shirakawa S, Ushihama N, Yamada Y, Kondo Y, Takeo T, Nakagata N, Motoyama K, Higashi T, Arima H, Kurauchi Y, Seki T, Katsuki H, Higaki K, Matsuo M, Irie T., Free PMC Article

    04/13/2021
    Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model.

    Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model.
    Lv K, Liu Y, Zheng Y, Dai S, Yin P, Miao H., Free PMC Article

    04/3/2021
    GPNMB contributes to a vicious circle for chronic obstructive pulmonary disease.

    GPNMB contributes to a vicious circle for chronic obstructive pulmonary disease.
    Zhang XJ, Cui ZH, Dong Y, Liang XW, Zhao YX, Baranova A, Cao H, Wang L., Free PMC Article

    03/27/2021
    Three novel mutations in GPNMB in two pedigrees with amyloidosis cutis dyschromica.

    Three novel mutations in GPNMB in two pedigrees with amyloidosis cutis dyschromica.
    Wang J, Li Y, Xing L, Zhao M, Zhang S, Li Z, Yao Z, Li M.

    03/13/2021
    [Amyloidosis cutis dyschromica due to homozygous variants of the GPNMB gene in a Chinese pedigree].

    [Amyloidosis cutis dyschromica due to homozygous variants of the GPNMB gene in a Chinese pedigree].
    Sha Y, Li L.

    02/20/2021
    Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis.

    Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis.
    Oeckl P, Weydt P, Thal DR, Weishaupt JH, Ludolph AC, Otto M.

    01/23/2021
    DC-HIL/Gpnmb Is a Negative Regulator of Tumor Response to Immune Checkpoint Inhibitors.

    DC-HIL/Gpnmb Is a Negative Regulator of Tumor Response to Immune Checkpoint Inhibitors.
    Chung JS, Ramani V, Kobayashi M, Fattah F, Popat V, Zhang S, Cruz PD Jr, Gerber DE, Ariizumi K.

    01/16/2021
    CSE1L silence inhibits the growth and metastasis in gastric cancer by repressing GPNMB via positively regulating transcription factor MITF.

    CSE1L silence inhibits the growth and metastasis in gastric cancer by repressing GPNMB via positively regulating transcription factor MITF.
    Li Y, Yuan S, Liu J, Wang Y, Zhang Y, Chen X, Si W.

    12/19/2020
    Transcriptome analysis reveals GPNMB as a potential therapeutic target for gastric cancer.

    Transcriptome analysis reveals GPNMB as a potential therapeutic target for gastric cancer.
    Ren F, Zhao Q, Liu B, Sun X, Tang Y, Huang H, Mei L, Yu Y, Mo H, Dong H, Zheng P, Mi Y.

    12/19/2020
    Of the macrophages in tumors that exhibited distinct transcriptional states, tumor-associated macrophages (TAMs) were associated with poor prognosis, and we established the inflammatory role of SLC40A1 and GPNMB in these cells

    Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma.
    Zhang Q, He Y, Luo N, Patel SJ, Han Y, Gao R, Modak M, Carotta S, Haslinger C, Kind D, Peet GW, Zhong G, Lu S, Zhu W, Mao Y, Xiao M, Bergmann M, Hu X, Kerkar SP, Vogt AB, Pflanz S, Liu K, Peng J, Ren X, Zhang Z.

    05/30/2020
    High GPNMB expression is associated with Renal Cell Carcinoma.

    TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease.
    Baba M, Furuya M, Motoshima T, Lang M, Funasaki S, Ma W, Sun HW, Hasumi H, Huang Y, Kato I, Kadomatsu T, Satou Y, Morris N, Karim BO, Ileva L, Kalen JD, Wilan Krisna LA, Hasumi Y, Sugiyama A, Kurahashi R, Nishimoto K, Oyama M, Nagashima Y, Kuroda N, Araki K, Eto M, Yao M, Kamba T, Suda T, Oike Y, Schmidt LS, Linehan WM., Free PMC Article

    04/18/2020
    Study demonstrated that miR-508-5p regulated the osteogenesis of hDPCs by targeting GPNMB and provided novel insight into the critical roles of microRNAs in hDPC differentiation.

    The suppressive effects of miR-508-5p on the odontogenic differentiation of human dental pulp stem cells by targeting glycoprotein non-metastatic melanomal protein B.
    Liu F, Wang X, Yang Y, Hu R, Wang W, Wang Y., Free PMC Article

    04/11/2020
    We identified GPNMB from IL6 as a target gene regulated by rs2069837. We revealed preferential recruitment of MEF2-HDAC repressive complex to the Takayasu arteritis risk allele. Our data show the risk allele in rs2069837 represses the expression of GPNMB by recruiting MEF2-HDAC complex, enabled through a long-range intrachromatin looping. Suppression of GPNMB might mediate increased susceptibility in Takayasu arteritis.

    Takayasu arteritis risk locus in <i>IL6</i> represses the anti-inflammatory gene <i>GPNMB</i> through chromatin looping and recruiting MEF2-HDAC complex.
    Kong X, Sawalha AH., Free PMC Article

    04/4/2020
    GPNMB overexpression is associated with Breast Cancer.

    A Human Organotypic Microfluidic Tumor Model Permits Investigation of the Interplay between Patient-Derived Fibroblasts and Breast Cancer Cells.
    Truong DD, Kratz A, Park JG, Barrientos ES, Saini H, Nguyen T, Pockaj B, Mouneimne G, LaBaer J, Nikkhah M., Free PMC Article

    03/14/2020
    GPNMB is highly expressed in gum tissue with Periodontal Disease and may be an anti-inflammatory player in the pathogenesis of Periodontal Disease.

    Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Ameliorates the Inflammatory Response in Periodontal Disease.
    Song R, Lin L.

    01/18/2020
    GPNMB was overexpressed in human head and neck squamous cell carcinoma tissue and predicted poor prognosis in human head and neck squamous cell carcinoma tissue. In addition, GPNMB expression was closely correlated with N stage in patients with head and neck squamous cell carcinoma.

    High expression of GPNMB predicts poor prognosis in head and neck squamous cell carcinoma.
    Li H, Xiao Y, Wu CC, Yang LL, Cao LY, Chen DR, Zhou JJ, Zhang WF, Sun ZJ.

    12/21/2019
    A novel, pro-growth role for GPNMB in Wnt-1 expressing basal breast cancers.

    GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and β-catenin activity.
    Maric G, Annis MG, MacDonald PA, Russo C, Perkins D, Siwak DR, Mills GB, Siegel PM.

    12/21/2019
    Region-specific elevations of GPNMB protein were found in substantia nigra of Parkinson's disease patients.

    The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress.
    Moloney EB, Moskites A, Ferrari EJ, Isacson O, Hallett PJ., Free PMC Article

    09/7/2019
    Upregulated GPNMB levels in EOC [ epithelial ovarian cancer ]patients are associated with dismal prognosis. Moreover, findings in the current study indicate that GPNMB is a potentially useful prognostic predictor of the therapeutic approaches for EOC [ epithelial ovarian cancer ].

    Overexpression of GPNMB predicts an unfavorable outcome of epithelial ovarian cancer.
    Ma RQ, Tang ZJ, Ye X, Cheng HY, Sun KK, Chang XH, Cui H.

    08/10/2019
    Study provides evidence that the kringle-like domain (KLD) of GPNMB plays an important role in its tumorigenic potential.

    Role of the kringle-like domain in glycoprotein NMB for its tumorigenic potential.
    Xie R, Okita Y, Ichikawa Y, Fikry MA, Huynh Dam KT, Tran STP, Kato M., Free PMC Article

    07/20/2019
    This study showed that GPNMB represents a novel disease-associated marker that appears to play a role in the neuroinflammatory response of Alzheimer's disease .

    Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia.
    Hüttenrauch M, Ogorek I, Klafki H, Otto M, Stadelmann C, Weggen S, Wiltfang J, Wirths O., Free PMC Article

    06/15/2019
    Lower levels of GPNMB were also observed in patients with heart failure (HF) from the METSIM study compared to non-HF controls.

    Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans.
    Lin LY, Chun Chang S, O'Hearn J, Hui ST, Seldin M, Gupta P, Bondar G, Deng M, Jauhiainen R, Kuusisto J, Laakso M, Sinsheimer JS, Deb A, Rau C, Ren S, Wang Y, Lusis AJ, Wang JJ, Huertas-Vazquez A., Free PMC Article

    03/23/2019
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