| Myxoid epithelioid smooth muscle tumor of the vulva: A distinct entity with MEF2D::NCOA2 gene fusion. | Myxoid epithelioid smooth muscle tumor of the vulva: A distinct entity with MEF2D::NCOA2 gene fusion.
Warmke LM, Mustafa A, Zou YS, Davis JL, Ulbright TM, Segura SE. | 01/9/2024 |
| VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis. | VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis.
Watson S, LaVigne CA, Xu L, Surdez D, Cyrta J, Calderon D, Cannon MV, Kent MR, Silvius KM, Kucinski JP, Harrison EN, Murchison W, Rakheja D, Tirode F, Delattre O, Amatruda JF, Kendall GC., Free PMC Article | 02/11/2023 |
| A GRIP-1-EZH2 switch binding to GATA-4 is linked to the genesis of rhabdomyosarcoma through miR-29a. | A GRIP-1-EZH2 switch binding to GATA-4 is linked to the genesis of rhabdomyosarcoma through miR-29a.
Song YL, Yang MH, Zhang S, Wang H, Kai KL, Yao CX, Dai FF, Zhou MJ, Li JB, Wei ZR, Yin Z, Zhu WG, Xue L, Zang MX. | 12/10/2022 |
| ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells. | ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells.
Fishman H, Madiwale S, Geron I, Bari V, Van Loocke W, Kirschenbaum Y, Ganmore I, Kugler E, Rein-Gil A, Friedlander G, Schiby G, Birger Y, Strehl S, Soulier J, Knoechel B, Ferrando A, Noy-Lotan S, Nagler A, Mulloy JC, Van Vlierberghe P, Izraeli S., Free PMC Article | 03/12/2022 |
| Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts. | Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts.
Kao YC, Bennett JA, Suurmeijer AJH, Dickson BC, Swanson D, Wanjari P, Zhang L, Lee JC, Antonescu CR., Free PMC Article | 01/29/2022 |
| Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR). | Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR).
Senicourt L, le Maire A, Allemand F, Carvalho JE, Guee L, Germain P, Schubert M, Bernadó P, Bourguet W, Sibille N. | 06/26/2021 |
| Establishment and Characterization of a Cell Line (S-RMS1) Derived from an Infantile Spindle Cell Rhabdomyosarcoma with SRF-NCOA2 Fusion Transcript. | Establishment and Characterization of a Cell Line (S-RMS1) Derived from an Infantile Spindle Cell Rhabdomyosarcoma with SRF-NCOA2 Fusion Transcript.
Colletti M, Galardi A, Miele E, Di Paolo V, Russo I, De Stefanis C, De Vito R, Rinelli M, Ciolfi A, De Angelis B, Zin A, Guffanti A, Digilio MC, Novelli A, Alaggio R, Milano GM, Di Giannatale A., Free PMC Article | 06/19/2021 |
| PFKFB4 promotes lung adenocarcinoma progression via phosphorylating and activating transcriptional coactivator SRC-2. | PFKFB4 promotes lung adenocarcinoma progression via phosphorylating and activating transcriptional coactivator SRC-2.
Meng J, Chen X, Han Z., Free PMC Article | 02/27/2021 |
| Knockdown of NCOA2 Inhibits the Growth and Progression of Gastric Cancer by Affecting the Wnt Signaling Pathway-Related Protein Expression. | Knockdown of NCOA2 Inhibits the Growth and Progression of Gastric Cancer by Affecting the Wnt Signaling Pathway-Related Protein Expression.
Lin Z, Yang F, Lu D, Sun W, Zhu G, Lan B., Free PMC Article | 01/9/2021 |
| Our results demonstrate uterine tumor resembling ovarian sex-cord tumors are defined by recurrent fusions involving NCOA2 or NCOA3 | Uterine Tumor Resembling Ovarian Sex Cord Tumor: A Distinct Entity Characterized by Recurrent NCOA2/3 Gene Fusions.
Dickson BC, Childs TJ, Colgan TJ, Sung YS, Swanson D, Zhang L, Antonescu CR., Free PMC Article | 11/16/2019 |
| Case Report:minute mesenchymal chondrosarcoma within an osteochondroma with HEY1-NCOA2 fusion. | Minute mesenchymal chondrosarcoma within osteochondroma: an unexpected diagnosis confirmed by HEY1-NCOA2 fusion.
Toki S, Motoi T, Miyake M, Kobayashi E, Kawai A, Yoshida A. | 10/26/2019 |
| SRC-2 controls the pentose phosphate pathway through RPIA in human endometrial cancer cells. | Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells.
Szwarc MM, Kommagani R, Putluri V, Dubrulle J, Stossi F, Mancini MA, Coarfa C, Lanz RB, Putluri N, DeMayo FJ, Lydon JP, O'Malley BW., Free PMC Article | 10/26/2019 |
| Case Reports: primitive spindle sarcomas of the kidney with novel MEIS1-NCOA2 gene fusions. | Novel MEIS1-NCOA2 Gene Fusions Define a Distinct Primitive Spindle Cell Sarcoma of the Kidney.
Argani P, Reuter VE, Kapur P, Brown JE, Sung YS, Zhang L, Williamson R, Francis G, Sommerville S, Swanson D, Dickson BC, Antonescu CR., Free PMC Article | 09/7/2019 |
| both SRC-2 and SRC-3 are essential for the epithelial-mesenchymal transition in breast cancer cells, controlling different transcriptional niches. | A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells.
Bozickovic O, Skartveit L, Engelsen AST, Helland T, Jonsdottir K, Flågeng MH, Fenne IS, Janssen E, Lorens JB, Bjørkhaug L, Sagen JV, Mellgren G. | 05/18/2019 |
| required for full induction of the retinol transporter, stimulated by retinoic acid 6 (STRA6), which is essential for endometrial stromal cell decidualization | Retinoid signaling controlled by SRC-2 in decidualization revealed by transcriptomics.
Szwarc MM, Hai L, Gibbons WE, White LD, Mo Q, Kommagani R, Lanz RB, DeMayo FJ, O'Malley BW, Lydon JP., Free PMC Article | 05/4/2019 |
| Case Reports/Review: indeterminate dendritic cell tumor lacking the ETV3-NCOA2 translocation. | Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.
Davick JJ, Kim J, Wick MR, Gru AA. | 01/12/2019 |
| Using quantitative biochemical, biophysical, and solution structural methods study shows that ligand and DNA cooperatively recruit the intrinsically disordered steroid receptor coactivator-2 (SRC-2/TIF2/GRIP1/NCoA-2) receptor interaction domain to peroxisome proliferator-activated receptor gamma-retinoid X receptor alpha (PPARgamma-RXRalpha) heterodimer and reveal the binding determinants of the complex. | Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA.
de Vera IMS, Zheng J, Novick S, Shang J, Hughes TS, Brust R, Munoz-Tello P, Gardner WJ Jr, Marciano DP, Kong X, Griffin PR, Kojetin DJ., Free PMC Article | 03/24/2018 |
| T3 promotes differentiation towards chondrocytes-like cells in our in vitro model, that this differentiation is mediated by steroid receptor co-activator 2 (SRC2) and does not induce hypertrophy | 3, 3', 5-triiodo-L-thyronine Increases In Vitro Chondrogenesis of Mesenchymal Stem Cells From Human Umbilical Cord Stroma Through SRC2.
Fernández-Pernas P, Fafián-Labora J, Lesende-Rodriguez I, Mateos J, De la Fuente A, Fuentes I, De Toro Santos J, Blanco García F, Arufe MC. | 09/23/2017 |
| Pancreatic involvement occurs in mesenchymal chondrosarcoma harboring the HEY1-NCOA2 gene fusion. | Pancreatic involvement by mesenchymal chondrosarcoma harboring the HEY1-NCOA2 gene fusion.
Cohen JN, Solomon DA, Horvai AE, Kakar S. | 09/2/2017 |
| Data suggest that steroid receptor coactivators (NCOA1, NCOA2, NCOA3) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW] | Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers.
Rohira AD, Lonard DM. | 08/19/2017 |
| SRC-2 may exhibit oncogenic or tumor suppressor activity depending on the target genes and nuclear receptors that are expressed in distinct tissues | SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.
Suresh S, Durakoglugil D, Zhou X, Zhu B, Comerford SA, Xing C, Xie XJ, York B, O'Donnell KA., Free PMC Article | 06/10/2017 |
| NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 domain of NCOA2 and the ETS DNAbinding domain of ETV4. | Gene fusions AHRR-NCOA2, NCOA2-ETV4, ETV4-AHRR, P4HA2-TBCK, and TBCK-P4HA2 resulting from the translocations t(5;8;17)(p15;q13;q21) and t(4;5)(q24;q31) in a soft tissue angiofibroma.
Panagopoulos I, Gorunova L, Viset T, Heim S., Free PMC Article | 03/11/2017 |
| Altered expression of TIF2 may play a role in adenomyosis development and treatment outcome with levonorgestrel-releasing intrauterine system. | Effects of a Levonorgestrel-Releasing Intrauterine System on the Expression of Steroid Receptor Coregulators in Adenomyosis.
Yun BH, Jeon YE, Seo SK, Park JH, Yoon SO, Cho S, Choi YS, Lee BS. | 12/17/2016 |
| evaluating if NCOA2 relative copy-number gain presents prognostic value for prostate cancer | NCOA2 is a candidate target gene of 8q gain associated with clinically aggressive prostate cancer.
Silva MP, Barros-Silva JD, Vieira J, Lisboa S, Torres L, Correia C, Vieira-Coimbra M, Martins AT, Jerónimo C, Henrique R, Paulo P, Teixeira MR. | 10/1/2016 |
| Report NcoA2-regulation of the AhR-ARNT-HIF-1a interaction. | NcoA2-Dependent Inhibition of HIF-1α Activation Is Regulated via AhR.
Tsai CH, Li CH, Liao PL, Cheng YW, Lin CH, Huang SH, Kang JJ. | 09/10/2016 |