| Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer. | Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer.
Tam KJ, Liu L, Hsing M, Dalal K, Thaper D, McConeghy B, Yenki P, Bhasin S, Peacock JW, Wang Y, Cherkasov A, Rennie PS, Gleave ME, Ong CJ., Free PMC Article | 04/5/2024 |
| Semaphorin 3C exacerbates liver fibrosis. | Semaphorin 3C exacerbates liver fibrosis.
De Angelis Rigotti F, Wiedmann L, Hubert MO, Vacca M, Hasan SS, Moll I, Carvajal S, Jiménez W, Starostecka M, Billeter AT, Müller-Stich B, Wolff G, Ekim-Üstünel B, Herzig S, Fandos-Ramo C, Krätzner R, Reich M, Keitel-Anselmino V, Heikenwälder M, Mogler C, Fischer A, Rodriguez-Vita J. | 11/7/2023 |
| Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells. | Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells.
Yenki P, Bhasin S, Liu L, Nabavi N, Cheng CW, Tam KJ, Peacock JW, Adomat HH, Tombe T, Fazli L, Ivanova L, Dusek C, Khosravi S, Guns EST, Wang Y, Buttyan R, Gleave ME, Ong CJ., Free PMC Article | 11/7/2023 |
| Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma. | Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma.
Hao J, Han X, Huang H, Yu X, Fang J, Zhao J, Prayson RA, Bao S, Yu JS., Free PMC Article | 05/5/2023 |
| SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling. | SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling.
Yenki P, Adomat HH, Ong CJ. | 08/28/2021 |
| MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling. | MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling.
Yin L, Li J, Wang J, Pu T, Wei J, Li Q, Wu BJ., Free PMC Article | 07/31/2021 |
| MiR-146a Regulates Migration and Invasion by Targeting NRP2 in Circulating-Tumor Cell Mimicking Suspension Cells. | MiR-146a Regulates Migration and Invasion by Targeting NRP2 in Circulating-Tumor Cell Mimicking Suspension Cells.
Do Y, Cho JG, Park JY, Oh S, Park D, Yoo KH, Lee MS, Kwon BS, Kim J, Yang Y., Free PMC Article | 07/31/2021 |
| Semaphorin-3C Is Upregulated in Polycystic Kidney Epithelial Cells and Inhibits Angiogenesis of Glomerular Endothelial Cells. | Semaphorin-3C Is Upregulated in Polycystic Kidney Epithelial Cells and Inhibits Angiogenesis of Glomerular Endothelial Cells.
Kim BH, Kim DY, Ahn Y, Lee EJ, Park H, Park M, Park JH. | 07/24/2021 |
| Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family. | Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family.
Carrion-Castillo A, Estruch SB, Maassen B, Franke B, Francks C, Fisher SE., Free PMC Article | 07/17/2021 |
| Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease. | Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease.
Gunadi, Ryantono F, Sethi R, Marcellus, Kalim AS, Imelda P, Melati D, Simanjaya S, Widitjiarso W, Pitaka RT, Arfian N, Iskandar K, Makhmudi A, Lai PS., Free PMC Article | 07/10/2021 |
| Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes. | Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.
Sakthikumar S, Roy A, Haseeb L, Pettersson ME, Sundström E, Marinescu VD, Lindblad-Toh K, Forsberg-Nilsson K., Free PMC Article | 04/3/2021 |
| LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C. | LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C.
Ducoli L, Agrawal S, Sibler E, Kouno T, Tacconi C, Hon CC, Berger SD, Müllhaupt D, He Y, Kim J, D'Addio M, Dieterich LC, Carninci P, de Hoon MJL, Shin JW, Detmar M., Free PMC Article | 03/20/2021 |
| Increased Expression of Sema3C Indicates a Poor Prognosis and Is Regulated by miR-142-5p in Glioma. | Increased Expression of Sema3C Indicates a Poor Prognosis and Is Regulated by miR-142-5p in Glioma.
Zhang H, Ma H, Zhang W, Duan D, Zhu G, Cao W, Liu B. | 12/5/2020 |
| Semaphorin 3 C is a Novel Adipokine Representing Exercise-Induced Improvements of Metabolism in Metabolically Healthy Obese Young Males. | Semaphorin 3 C is a Novel Adipokine Representing Exercise-Induced Improvements of Metabolism in Metabolically Healthy Obese Young Males.
Nam JS, Ahn CW, Park HJ, Kim YS., Free PMC Article | 12/5/2020 |
| Both, anti-angiogenic and anti-tumorigenic activities of Sema3C were enhanced by the treatment of sodium valproate and, importantly, were not attributed to the cytotoxic effects. | The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model.
Valiulytė I, Curkūnavičiūtė R, Ribokaitė L, Kazlauskas A, Vaitkevičiūtė M, Skauminas K, Valančiūtė A., Free PMC Article | 04/4/2020 |
| In the absence of neuropilins, plexin-A4 formed complexes with plexin-D1, and was required in addition to plexin-D1 to enable Sema3C-induced signal transduction. | Complexes of plexin-A4 and plexin-D1 convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilins.
Smolkin T, Nir-Zvi I, Duvshani N, Mumblat Y, Kessler O, Neufeld G. | 12/7/2019 |
| we show that SEMA3C promotes migration and invasion in vitro and cell dissemination in vivo. | Semaphorin 3 C drives epithelial-to-mesenchymal transition, invasiveness, and stem-like characteristics in prostate cells.
Tam KJ, Hui DHF, Lee WW, Dong M, Tombe T, Jiao IZF, Khosravi S, Takeuchi A, Peacock JW, Ivanova L, Moskalev I, Gleave ME, Buttyan R, Cox ME, Ong CJ., Free PMC Article | 06/22/2019 |
| Study provide the first evidence that SEMA3C, SEMA5A and SEMA6D can be considered as markers of liver injury in chronic hepatitis C. While serum concentrations of SEMA3C and SEMA6D significantly increased with fibrosis stage in both HCV-g1 and HCV-g3 infections, the concentration of SEMA5A inversely correlated with fibrosis stage in both HCV genotypes. | The association of semaphorins 3C, 5A and 6D with liver fibrosis stage in chronic hepatitis C.
Papic N, Zidovec Lepej S, Gorenec L, Grgic I, Gasparov S, Filipec Kanizaj T, Vince A., Free PMC Article | 06/1/2019 |
| in situ hybridization analysis revealed that Sema 3C and Sema 3F are expressed at the RNA level in the endometriosis affected peritoneum | Reduced Sympathetic Innervation in Endometriosis is Associated to Semaphorin 3C and 3F Expression.
Scheerer C, Frangini S, Chiantera V, Mechsner S. | 05/12/2018 |
| Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner in prostate tumor cells. | Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner.
Tam KJ, Dalal K, Hsing M, Cheng CW, Khosravi S, Yenki P, Tse C, Peacock JW, Sharma A, Chiang YT, Wang Y, Cherkasov A, Rennie PS, Gleave ME, Ong CJ., Free PMC Article | 02/24/2018 |
| The exploratory genome-wide association studies confirmed APOE and identified the novel loci: rs2525776 near SEMA3C (P = 1 x 10(-8), OR = 3.3 [2.1-5.1]). | Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.
Schott JM, Crutch SJ, Carrasquillo MM, Uphill J, Shakespeare TJ, Ryan NS, Yong KX, Lehmann M, Ertekin-Taner N, Graff-Radford NR, Boeve BF, Murray ME, Khan QU, Petersen RC, Dickson DW, Knopman DS, Rabinovici GD, Miller BL, González AS, Gil-Néciga E, Snowden JS, Harris J, Pickering-Brown SM, Louwersheimer E, van der Flier WM, Scheltens P, Pijnenburg YA, Galasko D, Sarazin M, Dubois B, Magnin E, Galimberti D, Scarpini E, Cappa SF, Hodges JR, Halliday GM, Bartley L, Carrillo MC, Bras JT, Hardy J, Rossor MN, Collinge J, Fox NC, Mead S., Free PMC Article | 10/7/2017 |
| Aberrant expression of sema3c is correlated with poor prognosis of pancreatic ductal adenocarcinoma patients and promotes tumor growth and metastasis by activating ERK1/2 signaling pathway. | Increased semaphorin 3c expression promotes tumor growth and metastasis in pancreatic ductal adenocarcinoma by activating the ERK1/2 signaling pathway.
Xu X, Zhao Z, Guo S, Li J, Liu S, You Y, Ni B, Wang H, Bie P. | 08/26/2017 |
| FR-sema3C could perhaps be used for the treatment of AMD. | A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization.
Toledano S, Lu H, Palacio A, Ziv K, Kessler O, Schaal S, Neufeld G, Barak Y., Free PMC Article | 07/1/2017 |
| SEMA3C plays a role in the progression of breast cancer and may positively influence breast cancer cell adhesion, invasion and proliferation, as well as being associated with grade of disease and estrogen receptor status. | Expression of Semaphorin 3C in Breast Cancer and its Impact on Adhesion and Invasion of Breast Cancer Cells.
Malik MF, Satherley LK, Davies EL, Ye L, Jiang WG. | 11/12/2016 |
| Data show significant increases in semaphorin3C, 3D and their receptor neuropilin-2 in degenerate samples which were shown to contain nerves and blood vessels, compared to non-degenerate samples without nerves and blood vessels. | Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc.
Binch AL, Cole AA, Breakwell LM, Michael AL, Chiverton N, Creemers LB, Cross AK, Le Maitre CL., Free PMC Article | 05/21/2016 |