| EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells. | EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells.
Xue M, Lin H, Liang HPH, Bereza-Malcolm L, Lynch T, Sinnathurai P, Weiler H, Jackson C, March L., Free PMC Article | 02/7/2024 |
| Structural and genomic analysis of single nucleotide polymorphisms in human host factor endothelial protein C receptor (EPCR) reveals complex interplay with malaria parasites. | Structural and genomic analysis of single nucleotide polymorphisms in human host factor endothelial protein C receptor (EPCR) reveals complex interplay with malaria parasites.
Gill J, Sharma A. | 08/11/2023 |
| Microvascular Environment Influences Brain Microvascular Heterogeneity: Relative Roles of Astrocytes and Oligodendrocytes for the EPCR Expression in the Brain Endothelium. | Microvascular Environment Influences Brain Microvascular Heterogeneity: Relative Roles of Astrocytes and Oligodendrocytes for the EPCR Expression in the Brain Endothelium.
Thakar M, Noumbissi ME, Stins MF., Free PMC Article | 05/5/2023 |
| Genetic variant of endothelial protein C receptor genes and its serum level in B thalassemic children. | Genetic variant of endothelial protein C receptor genes and its serum level in B thalassemic children.
Hesham M, Ali AS, Abogabela SM, Fawzy A, Mohamed NM, Mokhtar WA. | 03/8/2023 |
| Novel Diagnostic Autoantibodies Against Endothelial Protein C Receptor in Patients With Ulcerative Colitis. | Novel Diagnostic Autoantibodies Against Endothelial Protein C Receptor in Patients With Ulcerative Colitis.
Kakuta Y, Shirai T, McGovern DPB, Braun J, Fujii H, Masamune A. | 03/2/2023 |
| Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children. | Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children.
Blankson SO, Dikroh L, Tettey P, Tornyigah B, Adamou R, Moussiliou A, Alao MJ, Amoussou A, Padounou C, Milet J, Mensah BA, Aniweh Y, Ndam NT, Roussilhon C, Tahar R. | 01/21/2023 |
| Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction. | Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction.
Andres F, Hannan NJ, Walker SP, MacDonald TM, Wong GP, Murphy C, Cannon P, Kandel M, Masci J, Nguyen TV, Abboud A, Idzes D, Kyritsis V, Pritchard N, Tong S, Kaitu'u-Lino TJ. | 11/26/2022 |
| Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID-19? | Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID-19?
Ceylan MR, Kankılıç N, Öz Ö. | 09/10/2022 |
| Thrombotic Risk Determined by Protein C Receptor (PROCR) Variants among Middle-Aged and Older Adults: A Population-Based Cohort Study. | Thrombotic Risk Determined by Protein C Receptor (PROCR) Variants among Middle-Aged and Older Adults: A Population-Based Cohort Study.
Manderstedt E, Halldén C, Lind-Halldén C, Elf J, Svensson PJ, Engström G, Melander O, Baras A, Lotta LA, Zöller B, Regeneron Genetics Center. | 08/27/2022 |
| Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus. | Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus.
Stacey D, Chen L, Stanczyk PJ, Howson JMM, Mason AM, Burgess S, MacDonald S, Langdown J, McKinney H, Downes K, Farahi N, Peters JE, Basu S, Pankow JS, Tang W, Pankratz N, Sabater-Lleal M, de Vries PS, Smith NL, CHARGE Hemostasis Working Group, Gelinas AD, Schneider DJ, Janjic N, Samani NJ, Ye S, Summers C, Chilvers ER, Danesh J, Paul DS., Free PMC Article | 04/23/2022 |
| Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma. | Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
Zhang P, He Q, Wang Y, Zhou G, Chen Y, Tang L, Zhang Y, Hong X, Mao Y, He Q, Yang X, Liu N, Ma J., Free PMC Article | 04/9/2022 |
| Decoding the Host-Parasite Protein Interactions Involved in Cerebral Malaria Through Glares of Molecular Dynamics Simulations. | Decoding the Host-Parasite Protein Interactions Involved in Cerebral Malaria Through Glares of Molecular Dynamics Simulations.
Indari O, Sk MF, Jakhmola S, Jonniya NA, Jha HC, Kar P. | 02/26/2022 |
| Lentiviral CRISPR-guided RNA library screening identified Adam17 as an upstream negative regulator of Procr in mammary epithelium. | Lentiviral CRISPR-guided RNA library screening identified Adam17 as an upstream negative regulator of Procr in mammary epithelium.
Wu T, Wang Y, Xiao T, Ai Y, Li J, Zeng YA, Yu QC., Free PMC Article | 01/1/2022 |
| Determining the association of thrombophilic gene polymorphisms with recurrent pregnancy loss in Iranian women. | Determining the association of thrombophilic gene polymorphisms with recurrent pregnancy loss in Iranian women.
Khorshidi F, Hajizadeh S, Choobineh H, Alizadeh S, Sharifi MJ, Kavosh Z, Omidkhoda A. | 10/2/2021 |
| Down-regulation of endothelial protein C receptor promotes preeclampsia by affecting actin polymerization. | Down-regulation of endothelial protein C receptor promotes preeclampsia by affecting actin polymerization.
Wang H, Wang P, Liang X, Li W, Yang M, Ma J, Yue W, Fan S., Free PMC Article | 09/11/2021 |
| Elevated levels of soluble Endothelial protein C receptor in rheumatoid arthritis and block the therapeutic effect of protein C in collagen-induced arthritis. | Elevated levels of soluble Endothelial protein C receptor in rheumatoid arthritis and block the therapeutic effect of protein C in collagen-induced arthritis.
Bai L, Liu W, Guo P, Bai J, Liu Y, Hua Y, Pang C, Zhang W, Yin F, Wang Y. | 01/9/2021 |
| EPCR and ICAM-1 are important in Plasmodium falciparum binding to a 3D human brain microvessel model | Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1.
Bernabeu M, Gunnarsson C, Vishnyakova M, Howard CC, Nagao RJ, Avril M, Taylor TE, Seydel KB, Zheng Y, Smith JD., Free PMC Article | 02/15/2020 |
| As EPCR protein expression has not previously been shown in platelets, the presence of EPCR was confirmed in platelets using immunofluorescence, flow cytometry, immunoprecipitation, and mass spectrometry. This is the first demonstration that human platelets express EPCR. | Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity.
Fager AM, Machlus KR, Ezban M, Hoffman M., Free PMC Article | 12/28/2019 |
| The acquisition of antibodies against EPCR-binding cysteine-rich interdomain region alpha1 domains of PfEMP1 after a severe malaria episode suggest that EPCR-binding PfEMP1 may have a role in the pathogenesis of severe malaria in Papua New Guinea. | Acquisition of Antibodies Against Endothelial Protein C Receptor-Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Severe Malaria.
Rambhatla JS, Turner L, Manning L, Laman M, Davis TME, Beeson JG, Mueller I, Warrel J, Theander TG, Lavstsen T, Rogerson SJ. | 11/16/2019 |
| single nucleotide polymorphisms of endothelial protein C receptor are associated with Kawasaki disease susceptibility in a Chinese Han children | Polymorphisms in endothelial protein C receptor gene and Kawasaki disease susceptibility in a Chinese children.
Li Z, Jiang J, Huang L, Dai H, Chen J, Cai Q, Yang Z. | 11/16/2019 |
| biophysical analysis of a possible mode of ligand recognition by the EPCR via the involvement of phosphatidylcholine within its hydrophobic groove | Phosphatidylcholine in the groove of endothelial cell protein C receptor (EPCR) regulates EPCR conformation and protein C recognition.
Prasad R, Sen P. | 08/3/2019 |
| PROCR, but not THBD, polymorphisms are associated with early-onset ischemic stroke in young Caucasians. There were no PROCR or THBD associations in African-Americans. | Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.
Cole JW, Xu H, Ryan K, Jaworek T, Dueker N, McArdle P, Gaynor B, Cheng YC, O'Connell J, Bevan S, Malik R, Ahmed NU, Amouyel P, Anjum S, Bis JC, Crosslin D, Danesh J, Engelter ST, Fornage M, Frossard P, Gieger C, Giese AK, Grond-Ginsbach C, Ho WK, Holliday E, Hopewell J, Hussain M, Iqbal W, Jabeen S, Jannes J, Kamal A, Kamatani Y, Kanse S, Kloss M, Lathrop M, Leys D, Lindgren A, Longstreth WT Jr, Mahmood K, Meisinger C, Metso TM, Mosley T Jr, Müller-Nurasyid M, Norrving B, Parati E, Peters A, Pezzini A, Quereshi I, Rasheed A, Rauf A, Salam T, Shen J, Słowik A, Stanne T, Strauch K, Tatlisumak T, Thijs VN, Tiedt S, Traylor M, Waldenberger M, Walters M, Zhao W, Boncoraglio G, Debette S, Jern C, Levi C, Markus H, Meschia J, Rolfs A, Rothwell P, Saleheen D, Seshadri S, Sharma P, Sudlow C, Worrall B, METASTROKE Consortium of the ISGC, WTCCC-2 Consortium, Stine OC, Kittner SJ, Mitchell BD., Free PMC Article | 04/13/2019 |
| Plasma soluble EPCR was elevated in alpha-thalassemia intermedia. | Alterations of anticoagulant proteins and soluble endothelial protein C receptor in thalassemia patients of Chinese origin.
Huang Y, Long Y, Deng D, Liu Z, Liang H, Sun N, Xu Y, Lai Y, Cheng P. | 01/19/2019 |
| Recent studies provide a mechanistic basis to how EPCR contributes to PAR1-mediated biased signaling. EPCR may play a role in influencing a wide array of biological functions by binding to diverse ligands. | Endothelial cell protein C receptor-dependent signaling.
Pendurthi UR, Rao LVM., Free PMC Article | 01/5/2019 |
| PROCR H1 and H3 haplotypes were determined by genotyping 7014G/C and 1651C/G tag-polymorphisms, respectively. The PROCR H1 haplotype was less frequently found in antiphospholipid syndrome patients with arterial thrombosis, suggesting a protective effect of PROCR H1 against arterial thrombosis in these patients. | The H1 haplotype of the endothelial protein C receptor protects against arterial thrombosis in patients with antiphospholipid syndrome.
Plasín-Rodríguez MA, Rodríguez-Pintó I, Patricio P, Monteagudo J, Cervera R, Reverter JC, Espinosa G, Tàssies D. | 12/22/2018 |