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    AGR2 anterior gradient 2, protein disulphide isomerase family member [ Homo sapiens (human) ]

    Gene ID: 10551, updated on 3-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Clinical implications of AGR2 in primary prostate cancer: Results from a large-scale study.

    Clinical implications of AGR2 in primary prostate cancer: Results from a large-scale study.
    Wambach M, Montani M, Runz J, Stephan C, Jung K, Moch H, Eberli D, Bernhardt M, Hommerding O, Kreft T, Cronauer MV, Kremer A, Mayr T, Hauser S, Kristiansen G.

    03/15/2024
    Clinical value of serum and tissue AGR2 for diagnosis and prognosis in epithelial ovarian cancer.

    Clinical value of serum and tissue AGR2 for diagnosis and prognosis in epithelial ovarian cancer.
    Yan T, Wang H, Ma X, Cao J, Tong Y, Guo L, Lu R.

    10/20/2023
    Potential Role of AGR2 for Mammalian Skin Wound Healing.

    Potential Role of AGR2 for Mammalian Skin Wound Healing.
    Kosykh AV, Tereshina MB, Gurskaya NG., Free PMC Article

    05/19/2023
    AGR2 Gene Expression in Glioblastoma: A Novel Molecular Potential Target for Diagnosis and Treatment.

    AGR2 Gene Expression in Glioblastoma: A Novel Molecular Potential Target for Diagnosis and Treatment.
    Adilay HU, Evran S, Katar S, Ozdemir A, Kayhan A, Avcikurt AS, Gunaldi O, Guclu B, Tanriverdi O.

    04/7/2023
    ESE1/AGR2 axis antagonizes TGF-beta-induced epithelial-mesenchymal transition in low-grade pancreatic cancer.

    ESE1/AGR2 axis antagonizes TGF-β-induced epithelial-mesenchymal transition in low-grade pancreatic cancer.
    Xu HJ, Bai J, Tian Y, Feng X, Chen AP, Wang J, Wu J, Jin XR, Zhang F, Quan MY, Chen C, Lee KY, Zhang JS., Free PMC Article

    03/24/2023
    Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance.

    Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance.
    Ci H, Wu L., Free PMC Article

    01/11/2023
    A disorder clinically resembling cystic fibrosis caused by biallelic variants in the AGR2 gene.

    A disorder clinically resembling cystic fibrosis caused by biallelic variants in the AGR2 gene.
    Bertoli-Avella A, Hotakainen R, Al Shehhi M, Urzi A, Pareira C, Marais A, Al Shidhani K, Aloraimi S, Morales-Torres G, Fisher S, Demuth L, Moteleb Selim LA, Al Menabawy N, Busehail M, AlShaikh M, Gilani N, Chalabi DN, Alharbi NS, Alfadhel M, Abdelrahman M, Venselaar H, Anjum N, Saeed A, Alghamdi MA, Aljaedi H, Arabi H, Karageorgou V, Khan S, Hajjari Z, Radefeldt M, Al-Ali R, Tripolszki K, Jamhawi A, Paknia O, Cozma C, Cheema H, Ameziane N, Al-Muhsen S, Bauer P., Free PMC Article

    10/15/2022
    Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.

    Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.
    Fessart D, Villamor I, Chevet E, Delom F, Robert J., Free PMC Article

    07/30/2022
    Anterior gradient protein 2 is a marker of tumor aggressiveness in breast cancer and favors chemotherapyinduced senescence escape.

    Anterior gradient protein 2 is a marker of tumor aggressiveness in breast cancer and favors chemotherapy‑induced senescence escape.
    Maarouf A, Boissard A, Henry C, Leman G, Coqueret O, Guette C, Lelièvre E., Free PMC Article

    05/21/2022
    Characterization of the AGR2 Interactome Uncovers New Players of Protein Disulfide Isomerase Network in Cancer Cells.

    Characterization of the AGR2 Interactome Uncovers New Players of Protein Disulfide Isomerase Network in Cancer Cells.
    Bouchalova P, Sommerova L, Potesil D, Martisova A, Lapcik P, Koci V, Scherl A, Vonka P, Planas-Iglesias J, Chevet E, Bouchal P, Hrstka R., Free PMC Article

    04/16/2022
    Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease.

    Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease.
    Al-Shaibi AA, Abdel-Motal UM, Hubrack SZ, Bullock AN, Al-Marri AA, Agrebi N, Al-Subaiey AA, Ibrahim NA, Charles AK, COLORS in IBD-Qatar Study Group, Elawad M, Uhlig HH, Lo B., Free PMC Article

    04/2/2022
    Anterior gradient 2 regulates cancer progression in TP53wildtype esophageal squamous cell carcinoma.

    Anterior gradient 2 regulates cancer progression in TP53‑wild‑type esophageal squamous cell carcinoma.
    Takabatake K, Konishi H, Arita T, Kataoka S, Shibamoto J, Furuke H, Takaki W, Shoda K, Shimizu H, Yamamoto Y, Komatsu S, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E.

    01/22/2022
    (125)I seeds inhibit proliferation and promote apoptosis in cholangiocarcinoma cells by regulating the AGR2-mediated p38 MAPK pathway.

    (125)I seeds inhibit proliferation and promote apoptosis in cholangiocarcinoma cells by regulating the AGR2-mediated p38 MAPK pathway.
    Zhou X, Zhang W, Dou M, Li Z, Liu Z, Li J, Tian C, Yao Y, Wang C, Li Y, Chen P, Han X, Jiao D.

    01/8/2022
    Intracellular AGR2 transduces PGE2 stimuli to promote epithelial-mesenchymal transition and metastasis of colorectal cancer.

    Intracellular AGR2 transduces PGE2 stimuli to promote epithelial-mesenchymal transition and metastasis of colorectal cancer.
    Zhang H, Chi J, Hu J, Ji T, Luo Z, Zhou C, Huang L, Dai Z, Li J, Wang G, Wang L, Wang Z.

    01/8/2022
    Role of long intergenic non-protein coding RNA 01857 in hepatocellular carcinoma malignancy via the regulation of the microRNA-197-3p/anterior GRadient 2 axis.

    Role of long intergenic non-protein coding RNA 01857 in hepatocellular carcinoma malignancy via the regulation of the microRNA-197-3p/anterior GRadient 2 axis.
    Bi J, Guo Y, Li Q, Liu L, Bao S, Xu P., Free PMC Article

    01/1/2022
    Anterior gradient 2 promotes tumorigenesis through upregulation of CCAAT-enhancer binding protein beta and hypoxia-inducible factor-2alpha and subsequent secretion of interleukin-6, interleukin-8, and vascular endothelial growth factor in the Caki-1 clear cell renal cell carcinoma cell line.

    Anterior gradient 2 promotes tumorigenesis through upregulation of CCAAT-enhancer binding protein beta and hypoxia-inducible factor-2α and subsequent secretion of interleukin-6, interleukin-8, and vascular endothelial growth factor in the Caki-1 clear cell renal cell carcinoma cell line.
    Pajdzik K, Wilamowski M, Żurawek D, Stopa KB, Nodzyński M, Kalita A, Jura J.

    11/27/2021
    Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to beta-catenin that requires AGR2 dimerization and adhesion domains.

    Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to β-catenin that requires AGR2 dimerization and adhesion domains.
    Merugu SB, Zhou B, Mangukiya HB, Negi H, Ghulam R, Roy D, Qudsia S, Wang Z, Mashausi DS, Yunus FU, Liu GS, Li D.

    11/22/2021
    Correlation of AGR2 expression with the incidence of metastasis in luminal breast cancer.

    Correlation of AGR2 expression with the incidence of metastasis in luminal breast cancer.
    Kereh DS, Pieter J, Hamdani W, Haryasena H, Sampepajung D, Prihantono P.

    10/30/2021
    Anterior Gradient Protein 2 Promotes Mucosal Repair in Pediatric Ulcerative Colitis.

    Anterior Gradient Protein 2 Promotes Mucosal Repair in Pediatric Ulcerative Colitis.
    Ye X, Wu J, Li J, Wang H., Free PMC Article

    09/25/2021
    Extracellular AGR2 triggers lung tumour cell proliferation through repression of p21(CIP1).

    Extracellular AGR2 triggers lung tumour cell proliferation through repression of p21(CIP1).
    Fessart D, de Barbeyrac C, Boutin I, Grenier T, Richard E, Begueret H, Bernard D, Chevet E, Robert J, Delom F.

    07/17/2021
    Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2).

    Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2).
    Pirro M, Mohammed Y, de Ru AH, Janssen GMC, Tjokrodirijo RTN, Madunić K, Wuhrer M, van Veelen PA, Hensbergen PJ., Free PMC Article

    06/19/2021
    Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells.

    Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells.
    Hong X, Li ZX, Hou J, Zhang HY, Zhang CY, Zhang J, Sun H, Pang LH, Wang T, Deng ZH., Free PMC Article

    05/15/2021
    Long noncoding RNA LINC00460 conduces to tumor growth and metastasis of hepatocellular carcinoma through miR-342-3p-dependent AGR2 up-regulation.

    Long noncoding RNA LINC00460 conduces to tumor growth and metastasis of hepatocellular carcinoma through miR-342-3p-dependent AGR2 up-regulation.
    Hong H, Sui C, Qian T, Xu X, Zhu X, Fei Q, Yang J, Xu M., Free PMC Article

    03/13/2021
    Upregulation of AGR2vH facilitates cholangiocarcinoma cell survival under endoplasmic reticulum stress via the activation of the unfolded protein response pathway.

    Upregulation of AGR2vH facilitates cholangiocarcinoma cell survival under endoplasmic reticulum stress via the activation of the unfolded protein response pathway.
    Suwanmanee G, Yosudjai J, Phimsen S, Wongkham S, Jirawatnotai S, Kaewkong W.

    09/12/2020
    AGR2 is required for Twist1-induced proliferation, migration, and invasion of breast cancer cells.

    Basic helix-loop-helix transcription factor Twist1 is a novel regulator of anterior gradient protein 2 homolog (AGR2) in breast cancer.
    Jung SY, Yun J, Kim SJ, Kang S, Kim DY, Kim YJ, Park JH, Jang WB, Ji ST, Ha JS, Hong Van LT, Truong Giang LT, Rethineswaran VK, Kim DH, Song P, Kwon SM.

    07/18/2020
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