| Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome. | Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome.
Jiao B, Zhang H, Jiang H, Liu S, Wang Y, Chen Y, Duan H, Niu Y, Shen M, Wang H, Dai Y. | 04/10/2024 |
| GNLY gene polymorphism: A potential role in understanding psoriasis pathogenesis. | GNLY gene polymorphism: A potential role in understanding psoriasis pathogenesis.
Khalid HN, Elghobashy YAE, Elsayed AN. | 11/5/2022 |
| Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies. | Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies.
Yu R, Zhang J, Zhuo Y, Hong X, Ye J, Tang S, Zhang Y., Free PMC Article | 01/8/2022 |
| A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin. | A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin.
Hernández-Castañeda MA, Lavergne M, Casanova P, Nydegger B, Merten C, Subramanian BY, Matthey P, Lannes N, Mantel PY, Walch M., Free PMC Article | 09/25/2021 |
| Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis. | Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis.
Noschka R, Wondany F, Kizilsavas G, Weil T, Weidinger G, Walther P, Michaelis J, Stenger S., Free PMC Article | 09/25/2021 |
| Enhanced tuberculosis clearance through the combination treatment with recombinant adenovirus-mediated granulysin delivery. | Enhanced tuberculosis clearance through the combination treatment with recombinant adenovirus-mediated granulysin delivery.
Hao L, Ma J, Shi C, Lin X, Zhang Y, Jo-Lewis BN, Lei Q, Ullah N, Yao Z, Fan X., Free PMC Article | 05/29/2021 |
| Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. | Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts.
Crespo ÂC, Mulik S, Dotiwala F, Ansara JA, Sen Santara S, Ingersoll K, Ovies C, Junqueira C, Tilburgs T, Strominger JL, Lieberman J., Free PMC Article | 05/8/2021 |
| Association between seminal granulysin and malondialdehyde in infertile men with varicocele and the potential effect of varicocelectomy. | Association between seminal granulysin and malondialdehyde in infertile men with varicocele and the potential effect of varicocelectomy.
Kamal HM, El-Fallah AA, Abdelbaki SA, Khalil MM, Kamal MM, Behiry EG. | 04/3/2021 |
| The Role of IL-13, IL-15 and Granulysin in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. | The Role of IL-13, IL-15 and Granulysin in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
Sadek M, Iqbal O, Siddiqui F, Till S, Mazariegos M, Campbell E, Mudaliar K, Speiser J, Bontekoe E, Kouta A, Farooqui A, Daravath B, Qneibi D, Sadek R, Hoppensteadt D, Fareed J, Bouchard C., Free PMC Article | 02/27/2021 |
| Contributions of IFN-gamma and granulysin to the clearance of Plasmodium yoelii blood stage. | Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage.
Hojo-Souza NS, de Azevedo PO, de Castro JT, Teixeira-Carvalho A, Lieberman J, Junqueira C, Gazzinelli RT., Free PMC Article | 10/24/2020 |
| gammadelta T Cells Kill Plasmodium falciparum in a Granzyme- and Granulysin-Dependent Mechanism during the Late Blood Stage. | γδ T Cells Kill Plasmodium falciparum in a Granzyme- and Granulysin-Dependent Mechanism during the Late Blood Stage.
Hernández-Castañeda MA, Happ K, Cattalani F, Wallimann A, Blanchard M, Fellay I, Scolari B, Lannes N, Mbagwu S, Fellay B, Filgueira L, Mantel PY, Walch M., Free PMC Article | 10/24/2020 |
| granulysin and granzyme B synergize to restore carbapenem bactericidal activity and overcome carbapenem resistance in E. coli. | Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli.
Boulouis C, Sia WR, Gulam MY, Teo JQM, Png YT, Phan TK, Mak JYW, Fairlie DP, Poon IKH, Koh TH, Bergman P, Lim CM, Wang LF, Kwa ALH, Sandberg JK, Leeansyah E., Free PMC Article | 08/1/2020 |
| Granulysin+ cytotoxic cells are upregulated in blood and lesions of patients with psoriasis suggesting the involvement of granulysin mediated cytotoxicity in psoriasis pathogenesis. | Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis.
Vičić M, Kaštelan M, Sotošek Tokmadžić V, Prpić Massari L. | 04/18/2020 |
| GNLY mutation IS associated with Stevens-Johnson syndrome and toxic epidermal necrolysis. | Mutant GNLY is linked to Stevens-Johnson syndrome and toxic epidermal necrolysis.
Fonseca DJ, Caro LA, Sierra-Díaz DC, Serrano-Reyes C, Londoño O, Suárez YC, Mateus HE, Bolívar-Salazar D, Ramírez AF, de-la-Torre A, Laissue P. | 12/7/2019 |
| These studies provide a deeper insight into the subcellular localization and release mechanisms of the individual GNLY species. | Granulysin species segregate to different lysosome-related effector vesicles (LREV) and get mobilized by either classical or non-classical degranulation.
Lettau M, Dietz M, Dohmen K, Leippe M, Kabelitz D, Janssen O. | 05/11/2019 |
| Increased seminal granulysin has a negative impact on spermatogenesis in infertile men in general and in infertility associated with varicocele in particular. | Assessment of seminal granulysin in infertile men with varicocele.
Mikhael NW, El-Refaie AM, Sabry JH, Akl EM, Habashy AY, Mostafa T. | 01/19/2019 |
| The results suggest granulysin as a novel marker for a subset of cytotoxic natural killer cell derived malignancies | Granulysin, a novel marker for extranodal NK/T cell lymphoma, nasal type.
Lo Bello G, Akarca AU, Ambrosio MR, Agostinelli C, Molina-Kirsch H, Ramsay A, Rodriguez-Justo M, Pugh M, Zhao S, DeLisser M, Sabattini E, Dojcinov S, Pileri SA, Natkunam Y, Leoncini L, Marafioti T., Free PMC Article | 12/22/2018 |
| These results suggest that the 15 kDa granulysin exhibits a novel mechanism in bacteria killing in a way that's different from most antimicrobial peptides. | Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin.
Wei HM, Lin LC, Wang CF, Lee YJ, Chen YT, Liao YD., Free PMC Article | 07/15/2017 |
| Decreased blood granulysin at the protein level, is linked to the immunological condition of latent tuberculosis infection. | Circulating granulysin levels in healthcare workers and latent tuberculosis infection estimated using interferon-gamma release assays.
Thuong PH, Tam DB, Sakurada S, Hang NT, Hijikata M, Hong LT, Ngoc PT, Anh PT, Cuong VC, Matsushita I, Lien LT, Keicho N., Free PMC Article | 06/24/2017 |
| Carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells. | Effect of carbamate pesticides on perforin, granzymes A-B-3/K, and granulysin in human natural killer cells.
Li Q, Kobayashi M, Kawada T. | 04/8/2017 |
| serum GNLY is closely associated with the clinical characteristics of nasopharyngeal carcinoma and may be a potential biomarker for nasopharyngeal carcinoma | Evaluation of serum granulysin as a potential biomarker for nasopharyngeal carcinoma.
Lin J, Huang Y, Zhang L, Tang W, Li X, Wang X, Liu W. | 10/22/2016 |
| GNLY delivers Gzms into three protozoan parasites (Trypanosoma cruzi, Toxoplasma gondii and Leishmania major), in which the Gzms generate superoxide and inactivate oxidative defense enzymes to kill the parasite. | Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.
Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J., Free PMC Article | 07/2/2016 |
| Studies indicate that cytotoxic mechanisms mediated by granulysin and TRAIL (TNF-related apoptosis inducing ligand) seem to be less secondary effects on normal tissues. | Death ligands and granulysin: mechanisms of tumor cell death induction and therapeutic opportunities.
Martinez-Lostao L, de Miguel D, Al-Wasaby S, Gallego-Lleyda A, Anel A. | 06/28/2016 |
| High Granulysin expression is associated with Cutaneous T Cell Lymphoma and Sezary Syndrome. | Expression of Granulysin and FOXP3 in Cutaneous T Cell Lymphoma and Sézary Syndrome.
Shareef MM, Elgarhy LH, Wasfy Rel-S. | 05/14/2016 |
| A three-way interaction between SNPs in HLA-DQ and GNLY was identified in terms of HBV clearance. | Effects of interaction between genetic variants in human leukocyte antigen DQ and granulysin genes in Chinese Han subjects infected with hepatitis B virus.
Hou SH, Hu J, Zhang Y, Li QL, Guo JJ. | 01/16/2016 |