| Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human Fibroblasts by Affecting the Activity of Microfilaments. | Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human Fibroblasts by Affecting the Activity of Microfilaments.
Huang X, Qu R, Peng Y, Yang Y, Fan T, Sun B, Khan AU, Wu S, Wei K, Xu C, Dai J, Ouyang J, Zhong S., Free PMC Article | 09/25/2021 |
| Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers. | Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers.
Verdonschot JAJ, Robinson EL, James KN, Mohamed MW, Claes GRF, Casas K, Vanhoutte EK, Hazebroek MR, Kringlen G, Pasierb MM, van den Wijngaard A, Glatz JFC, Heymans SRB, Krapels IPC, Nahas S, Brunner HG, Szklarczyk R., Free PMC Article | 03/27/2021 |
| PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells. | PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells.
Shi Y, Wang X, Xu Z, He Y, Guo C, He L, Huan C, Cai C, Huang J, Zhang J, Li Y, Zeng C, Zhang X, Wang L, Ke Y, Cheng H., Free PMC Article | 02/6/2021 |
| Novel polymorphisms in PDLIM3 and PDLIM5 gene encoding Z-line proteins increase risk of idiopathic dilated cardiomyopathy. | Novel polymorphisms in PDLIM3 and PDLIM5 gene encoding Z-line proteins increase risk of idiopathic dilated cardiomyopathy.
Wang D, Fang J, Lv J, Pan Z, Yin X, Cheng H, Guo X., Free PMC Article | 09/5/2020 |
| Forces acting on integrins recruit Enigma family proteins (PDLIM5 AND PDLIM7) to trigger YAP activation during mechanotransduction. | Enigma proteins regulate YAP mechanotransduction.
Elbediwy A, Vanyai H, Diaz-de-la-Loza MD, Frith D, Snijders AP, Thompson BJ., Free PMC Article | 01/11/2020 |
| this study shows functional importance of PDLIM5 for proper kAE1 membrane residency, as a crucial linker between kidneyAE1 and actin cytoskeleton-associated proteins in polarized cells | PDLIM5 links kidney anion exchanger 1 (kAE1) to ILK and is required for membrane targeting of kAE1.
Su Y, Hiemstra TF, Yan Y, Li J, Karet HI, Rosen L, Moreno P, Karet Frankl FE., Free PMC Article | 10/27/2018 |
| PDLIM5 promotes papillary thyroid carcinoma via activation of the Ras-ERK pathway. | PDLIM5 identified by label-free quantitative proteomics as a potential novel biomarker of papillary thyroid carcinoma.
Wei X, Zhang Y, Yu S, Li S, Jiang W, Zhu Y, Xu Y, Yang C, Tian G, Mi J, Bergquist J, Zhao M, Song F. | 10/13/2018 |
| PDLIM5 was strongly up-regulated during cardiomyogenesis and novel stage-specific isoforms were detected for PDLIM5 | Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms.
Konze SA, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner FF. | 09/30/2017 |
| Findings provide evidence of shared genetic variants in PDLIM5 gene influencing alcohol dependence, type 2 diabetes, and hypertension. | Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension.
Owusu D, Pan Y, Xie C, Harirforoosh S, Wang KS. | 09/16/2017 |
| The study provides evidence of several genetic variants within the PDLIM5 gene and interactions between PDLIM5 and steroid use influencing cancer. | Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus.
Wang KS, Owusu D, Pan Y, Xie C. | 04/1/2017 |
| It can be deduced that the nonsynonymous rs7690296 polymorphism of PDLIM5 could play an important role in the pathophysiology of both bipolar disorder and schizophrenia. | Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia.
Zain MA, Roffeei SN, Zainal NZ, Kanagasundram S, Mohamed Z. | 06/14/2014 |
| PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. | [Association of prostate cancer with PDLIM5, SLC22A3 and NKX3-1 in Chinese men].
Hui J, Wang JY, Shi XH, Zhang YG, Liu M, Wang X, Wang NN, Chen X, Liang SY, Wei D, Zhao F, Zhang YH, Yang Z. | 03/16/2013 |
| The significant difference in expression of PDLIM5 mRNA in the peripheral blood leukocytes of treatment-naive bipolar (BPD) patients versus that of healthy control subjects suggests that it may be a good biological marker for BPD. | Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration.
Zain MA, Jahan SN, Reynolds GP, Zainal NZ, Kanagasundram S, Mohamed Z., Free PMC Article | 01/26/2013 |
| LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner. | LIM domains regulate protein kinase C activity: a novel molecular function.
Maturana AD, Nakagawa N, Yoshimoto N, Tatematsu K, Hoshijima M, Tanizawa K, Kuroda S. | 06/18/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer.
Sun J, Kader AK, Hsu FC, Kim ST, Zhu Y, Turner AR, Jin T, Zhang Z, Adolfsson J, Wiklund F, Zheng SL, Isaacs WB, Grönberg H, Xu J., Free PMC Article | 12/5/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.
Kim ST, Cheng Y, Hsu FC, Jin T, Kader AK, Zheng SL, Isaacs WB, Xu J, Sun J., Free PMC Article | 09/15/2010 |
| Our results suggest that PDLIM5 might play a role in susceptibility to bipolar disorder among the Chinese Han population. | Positive association between the PDLIM5 gene and bipolar disorder in the Chinese Han population.
Zhao T, Liu Y, Wang P, Li S, Zhou D, Zhang D, Chen Z, Wang T, Xu H, Feng G, He L, Yu L., Free PMC Article | 01/21/2010 |
| tested for an association between three single nucleotide polymorphisms at the PDLIM5 gene and lithium prophylaxis in a Sardinian sample comprised of 155 bipolar patients treated with lithium | The PDLIM5 gene and lithium prophylaxis: an association and gene expression analysis in Sardinian patients with bipolar disorder.
Squassina A, Congiu D, Manconi F, Manchia M, Chillotti C, Lampus S, Severino G, Zompo MD, Squassina A, Congiu D, Manconi F, Manchia M, Chillotti C, Lampus S, Severino G, Zompo MD. | 01/21/2010 |
| PDLIM5 may have a minor effect on susceptibility to bipolar disorder in Caucasians. | PDLIM5 and susceptibility to bipolar disorder: a family-based association study and meta-analysis.
Shi J, Badner JA, Liu C, Shi J, Badner JA, Liu C., Free PMC Articles: PMC2572255, PMC2572255 | 01/21/2010 |
| The aim of this study was to investigate the association between PDLIM5 single nucleotide polymorphisms and bipolar disorder in a case-control sample. | A case-control association study of the PDLIM5 gene and bipolar disorder in a Sardinian sample.
Squassina A, Manchia M, Manconi F, Piccardi M, Ardau R, Chillotti C, Severino G, Del Zompo M, Squassina A, Manchia M, Manconi F, Piccardi M, Ardau R, Chillotti C, Severino G, Del Zompo M. | 01/21/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesIdentification of seven new prostate cancer susceptibility loci through a genome-wide association study.
Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK ProtecT Study Collaborators, PRACTICAL Consortium, Easton DF. PDLIM5 and susceptibility to bipolar disorder: a family-based association study and meta-analysis.
Shi J, Badner JA, Liu C, Shi J, Badner JA, Liu C. | 06/4/2008 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | The PDLIM5 gene and lithium prophylaxis: an association and gene expression analysis in Sardinian patients with bipolar disorder.
Squassina A, Congiu D, Manconi F, Manchia M, Chillotti C, Lampus S, Severino G, Zompo MD, Squassina A, Congiu D, Manconi F, Manchia M, Chillotti C, Lampus S, Severino G, Zompo MD. | 05/14/2008 |
| our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia | Positive association between PDLIM5 and schizophrenia in the Chinese Han population.
Li C, Tao R, Qin W, Zheng Y, He G, Shi Y, Li X, Guo Z, Chen H, Feng G, He L, Li C, Tao R, Qin W, Zheng Y, He G, Shi Y, Li X, Guo Z, Chen H, Feng G, He L. | 01/21/2010 |
| PDLIM5 gene is associated with recurrent major depressive disorder. | A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder.
Liu Z, Liu W, Xiao Z, Wang G, Yin S, Zhu F, Wang H, Cheng J, Wang X, He X, Li W, Liu Z, Liu W, Xiao Z, Wang G, Yin S, Zhu F, Wang H, Cheng J, Wang X, He X, Li W., Free PMC Articles: PMC2186365, PMC2186365 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (7) articlesCase-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.
Yosifova A, Mushiroda T, Stoianov D, Vazharova R, Dimova I, Karachanak S, Zaharieva I, Milanova V, Madjirova N, Gerdjikov I, Tolev T, Velkova S, Kirov G, Owen MJ, O'Donovan MC, Toncheva D, Nakamura Y. A case-control association study of the PDLIM5 gene and bipolar disorder in a Sardinian sample.
Squassina A, Manchia M, Manconi F, Piccardi M, Ardau R, Chillotti C, Severino G, Del Zompo M, Squassina A, Manchia M, Manconi F, Piccardi M, Ardau R, Chillotti C, Severino G, Del Zompo M. A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder.
Liu Z, Liu W, Xiao Z, Wang G, Yin S, Zhu F, Wang H, Cheng J, Wang X, He X, Li W, Liu Z, Liu W, Xiao Z, Wang G, Yin S, Zhu F, Wang H, Cheng J, Wang X, He X, Li W. Positive association between PDLIM5 and schizophrenia in the Chinese Han population.
Li C, Tao R, Qin W, Zheng Y, He G, Shi Y, Li X, Guo Z, Chen H, Feng G, He L, Li C, Tao R, Qin W, Zheng Y, He G, Shi Y, Li X, Guo Z, Chen H, Feng G, He L. Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia.
Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T. A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia.
Horiuchi Y, Arai M, Niizato K, Iritani S, Noguchi E, Ohtsuki T, Koga M, Kato T, Itokawa M, Arinami T. Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia.
Kato T, Iwayama Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y, Nakamura K, Mori N, Fujii K, Nanko S, Yoshikawa T. | 03/13/2008 |