| Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection. | Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection.
Teo QW, Wong HH, Heunis T, Stancheva V, Hachim A, Lv H, Siu L, Ho J, Lan Y, Mok CKP, Ulferts R, Sanyal S., Free PMC Article | 12/15/2023 |
| Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease. | Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.
Li BT, Sun M, Li YF, Wang JQ, Zhou ZM, Song BL, Luo J., Free PMC Article | 09/26/2020 |
| erlin-1 protein is required early in the infection, downstream of cell entry and primary translation, specifically to initiate RNA replication, and later in the infection to support infectious virus production. This study identifies erlin-1 protein as an important cellular factor regulating HCV infection. | The Host Factor Erlin-1 is Required for Efficient Hepatitis C Virus Infection.
Whitten-Bauer C, Chung J, Gómez-Moreno A, Gomollón-Zueco P, Huber MD, Gerace L, Garaigorta U., Free PMC Article | 08/1/2020 |
| Erlin-1 and the related erlin-2 were found to selectively bind cholesterol. Knockdown of the proteins by RNAi in cultured cells resulted in high levels of cholesterol and fatty acid biosynthesis in the presence of cholesterol sufficiency. | Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
Huber MD, Vesely PW, Datta K, Gerace L, Huber MD, Vesely PW, Datta K, Gerace L., Free PMC Articles: PMC3824017, PMC3824017 | 03/16/2015 |
| Here we show that the multimeric ER proteins erlins-1 and -2 are additional sterol regulatory element binding protein regulators. | Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
Huber MD, Vesely PW, Datta K, Gerace L, Huber MD, Vesely PW, Datta K, Gerace L., Free PMC Articles: PMC3824017, PMC3824017 | 01/11/2014 |
| Our findings suggest ERLIN1-CHUK-CWF19L1 variants are associated with early stage of fatty liver accumulation to hepatic inflammation. | The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
Feitosa MF, Wojczynski MK, North KE, Zhang Q, Province MA, Carr JJ, Borecki IB., Free PMC Article | 11/16/2013 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadié M, Foretová L, Cocco P, González-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S., Free PMC Article | 12/5/2010 |
| This protein has been found differentially expressed in thalami from patients with schizophrenia. | Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, Falkai P, Schmitt A, Turck CW. | 07/13/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| m3 receptor-expressing HeLa cells are a valuable system for studying IP(3) receptor ERAD, and suggest that the SPFH1/2 complex is a factor that selectively mediates the ERAD of activated IP(3) receptors. | SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.
Wang Y, Pearce MM, Sliter DA, Olzmann JA, Christianson JC, Kopito RR, Boeckmann S, Gagen C, Leichner GS, Roitelman J, Wojcikiewicz RJ., Free PMC Article | 01/21/2010 |
| Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) | Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.
Yuan X, Waterworth D, Perry JR, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, Bergmann S, Beckmann ND, Li Y, Ferrucci L, Melzer D, Hernandez D, Singleton A, Scott J, Elliott P, Waeber G, Cardon L, Frayling TM, Kooner JS, Mooser V., Free PMC Article | 08/12/2009 |
| Results suggest that this novel SPFH1/2 complex is a recognition factor that targets IP(3)Rs and perhaps other substrates for ERAD. | An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.
Pearce MM, Wormer DB, Wilkens S, Wojcikiewicz RJ., Free PMC Article | 01/21/2010 |
| Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. | Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER.
Browman DT, Resek ME, Zajchowski LD, Robbins SM. | 01/21/2010 |