| Data show that p53 and EAF2 knockout mice developed prostate cancer. | Combined Loss of EAF2 and p53 Induces Prostate Carcinogenesis in Male Mice.
Wang Y, Pascal LE, Zhong M, Ai J, Wang D, Jing Y, Pilch J, Song Q, Rigatti LH, Graham LE, Nelson JB, Parwani AV, Wang Z., Free PMC Article | 12/23/2017 |
| The results showed that Eaf2 knockout can reduce UV-induced apoptosis in crystalline lenses and mitigate the formation of cataracts. | Effects of ELL-associated factor 2 on ultraviolet radiation-induced cataract formation in mice.
Jiang Y, Fu R, Zhao J, Wu D, Qiao G, Li R, Zhang J., Free PMC Article | 08/20/2016 |
| These results demonstrate that EAF2-mediated apoptosis in GC B cells limits excessive humoral immune responses and is important for maintaining self-tolerance. | EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity.
Li Y, Takahashi Y, Fujii S, Zhou Y, Hong R, Suzuki A, Tsubata T, Hase K, Wang JY., Free PMC Article | 07/30/2016 |
| these findings together demonstrated synergistic functional interactions and clinical relevance of concurrent EAF2 and Pten downregulation in prostate carcinogenesis. | Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model.
Ai J, Pascal LE, O'Malley KJ, Dar JA, Isharwal S, Qiao Z, Ren B, Rigatti LH, Dhir R, Xiao W, Nelson JB, Wang Z., Free PMC Article | 07/12/2014 |
| Mice deficient in EAF2 had an increased recovery rate and a decreased overall response to the effects of androgen deprivation. | Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
Pascal LE, Ai J, Masoodi KZ, Wang Y, Wang D, Eisermann K, Rigatti LH, O'Malley KJ, Ma HM, Wang X, Dar JA, Parwani AV, Simons BW, Ittman MM, Li L, Davies BJ, Wang Z., Free PMC Article | 07/12/2014 |
| cooperation of VHL and EAF2 may be critical for angiogenic regulation of the liver and prostate, and concurrent loss of these two tumor suppressors may result in a pro-angiogenic phenotype. | EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate.
Pascal LE, Ai J, Rigatti LH, Lipton AK, Xiao W, Gnarra JR, Wang Z., Free PMC Article | 12/3/2011 |
| Inhibition of 5alpha-reductase during prostatic tumor regrowth enhances the expression of U19/Eaf2, an androgen-regulated tumor suppressor. | Inhibition of 5alpha-reductase enhances testosterone-induced expression of U19/Eaf2 tumor suppressor during the regrowth of LNCaP xenograft tumor in nude mice.
Gupta S, Wang Y, Ramos-Garcia R, Shevrin D, Nelson JB, Wang Z., Free PMC Article | 09/27/2010 |
| Data show that the expression of TSP-1 is down-regulated in the prostate and liver of U19/EAF2 knockout mouse. | Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53.
Su F, Pascal LE, Xiao W, Wang Z., Free PMC Article | 02/15/2010 |
| Following UV irradiation, Eaf2 is relocalized to the nucleolus, suggesting a possible functional involvement of Eaf2 in DNA damage response. | Dynamic intracellular distribution of Eaf2 and its potential involvement in UV-Induced DNA damage response.
Zhuang F, Yen P, Zhao J, Nguyen M, Jiang M, Liu YH., Free PMC Article | 01/21/2010 |
| Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia | U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia.
Xiao W, Zhang Q, Habermacher G, Yang X, Zhang AY, Cai X, Hahn J, Liu J, Pins M, Doglio L, Dhir R, Gingrich J, Wang Z., Free PMC Article | 01/21/2010 |
| Transcriptional activation mediated by FESTA/EAF2, a transcription factor that interacts with S-II, was decreased in RNA polymerase II deficient embryonic stem cells. | Defective FESTA/EAF2-mediated transcriptional activation in S-II-deficient embryonic stem cells.
Ito T, Saso K, Arimitsu N, Sekimizu K. | 01/21/2010 |
| Expression of Eaf2 is developmentally regulated. | Expression of murine ELL-associated factor 2 (Eaf2) is developmentally regulated.
Li M, Wu X, Zhuang F, Jiang S, Jiang M, Liu YH. | 01/21/2010 |