| CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of beta-catenin. | CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of β-catenin.
He J, Xu S, Jiang M, Wang T, Zhang Y, Jia Z, Bai M, Zhang A. | 03/7/2023 |
| Septin 9 controls CCNB1 stabilization via APC/C[CDC20] during meiotic metaphase I/anaphase I transition in mouse oocytes. | Septin 9 controls CCNB1 stabilization via APC/C(CDC20) during meiotic metaphase I/anaphase I transition in mouse oocytes.
Chen L, Ouyang YC, Gu LJ, Guo JN, Han ZM, Wang ZB, Hou Y, Schatten H, Sun QY., Free PMC Article | 02/4/2023 |
| Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer. | Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer.
Chen OJ, Castellsagué E, Moustafa-Kamal M, Nadaf J, Rivera B, Fahiminiya S, Wang Y, Gamache I, Pacifico C, Jiang L, Carrot-Zhang J, Witkowski L, Berghuis AM, Schönberger S, Schneider D, Hillmer M, Bens S, Siebert R, Stewart CJR, Zhang Z, Chao WCH, Greenwood CMT, Barford D, Tischkowitz M, Majewski J, Foulkes WD, Teodoro JG. | 10/8/2022 |
| Conditional knockout of Cdc20 attenuates osteogenesis in craniofacial bones. | Conditional knockout of Cdc20 attenuates osteogenesis in craniofacial bones.
Cheng Y, Du Y, Zhang X, Zhang P, Liu Y. | 08/20/2022 |
| Oscillation of Cdc20-APC/C-mediated CAMDI stability is critical for cortical neuron migration. | Oscillation of Cdc20-APC/C-mediated CAMDI stability is critical for cortical neuron migration.
Okuda S, Sato M, Kato S, Nagashima S, Inatome R, Yanagi S, Fukuda T., Free PMC Article | 12/4/2021 |
| CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65. | CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65.
Du Y, Zhang M, Liu X, Li Z, Hu M, Tian Y, Lv L, Zhang X, Liu Y, Zhang P, Zhou Y., Free PMC Article | 10/30/2021 |
| CDC20 inhibitor Apcin inhibits embryo implantation in vivo and in vitro. | CDC20 inhibitor Apcin inhibits embryo implantation in vivo and in vitro.
Guo C, Kong F, Lv Y, Gao N, Xiu X, Sun X., Free PMC Article | 02/27/2021 |
| Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development.
Zhao L, Xue S, Yao Z, Shi J, Chen B, Wu L, Sun L, Xu Y, Yan Z, Li B, Mao X, Fu J, Zhang Z, Mu J, Wang W, Du J, Liu S, Dong J, Wang W, Li Q, He L, Jin L, Liang X, Kuang Y, Sun X, Wang L, Sang Q., Free PMC Article | 02/6/2021 |
| PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21. | PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.
Liu X, Zhang F, Zhang Y, Li X, Chen C, Zhou M, Yu Z, Liu Y, Zhao Y, Hao X, Tang Y, Zhu L, Liu L, Xie L, Gu H, Shao H, Xia F, Yin C, Tao M, Xie J, Zhang CC, Yang Y, Sun H, Chen GQ, Zheng J. | 10/5/2019 |
| Enforced expression of CDC20 in cardiomyocytes and in the heart aggravated the hypertrophic response. Furthermore, the authors found that CDC20 directly targeted LC3, a key regulator of autophagy, and promoted LC3 ubiquitination and degradation by the proteasome, which inhibited autophagy leading to cardiac hypertrophy. | CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy.
Xie YP, Lai S, Lin QY, Xie X, Liao JW, Wang HX, Tian C, Li HH., Free PMC Article | 09/7/2019 |
| Cdc20 hypomorphism causes chromatin bridging and chromosome misalignment, revealing a requirement for Cdc20 in efficient sister chromosome separation and chromosome-microtubule attachment. | Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.
Malureanu L, Jeganathan KB, Jin F, Baker DJ, van Ree JH, Gullon O, Chen Z, Henley JR, van Deursen JM., Free PMC Article | 02/26/2011 |
| The physiologically effective threshold level of Cdc20 is high for female meiosis I. | Cdc20 is critical for meiosis I and fertility of female mice.
Jin F, Hamada M, Malureanu L, Jeganathan KB, Zhou W, Morbeck DE, van Deursen JM., Free PMC Article | 01/8/2011 |
| Results indicate that Cdc20 also contributes to post-anaphase activation of the APC/C. | Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F.
Gurden MD, Holland AJ, van Zon W, Tighe A, Vergnolle MA, Andres DA, Spielmann HP, Malumbres M, Wolthuis RM, Cleveland DW, Taylor SS., Free PMC Article | 05/3/2010 |
| Results indicate that the spindle assembly checkpoint-mediated inhibition of Cdc20 is an important tumor-suppressing mechanism. | Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.
Li M, Fang X, Wei Z, York JP, Zhang P., Free PMC Article | 01/21/2010 |
| Data show that the BubR1 N terminus binds to Cdc20 to inhibit APC/C activity in interphase, thereby allowing accumulation of cyclin B in G(2) phase prior to mitosis onset. | BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase.
Malureanu LA, Jeganathan KB, Hamada M, Wasilewski L, Davenport J, van Deursen JM., Free PMC Article | 01/21/2010 |
| findings suggest a novel function of HSF1 frequently overexpressed in cancer cells, to inhibit APC/C activity by interacting with Cdc20, and to result in aneuploidy development and genomic instability | A novel function for HSF1-induced mitotic exit failure and genomic instability through direct interaction between HSF1 and Cdc20.
Lee YJ, Lee HJ, Lee JS, Jeoung D, Kang CM, Bae S, Lee SJ, Kwon SH, Kang D, Lee YS. | 01/21/2010 |
| Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes | Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes.
Yin S, Liu JH, Ai JS, Xiong B, Wang Q, Hou Y, Chen DY, Sun QY. | 01/21/2010 |
| This cell division cycle protein is a key regulator of the cell cycle. | The role of p55CDC in cell cycle control and mammalian cell proliferation, differentiation, and apoptosis.
Lin M, Chang JK, Shankar D, Sakamoto KM. | 01/21/2010 |
| Expression of the cdc20 gene is down-regulated by zif268 in neuronal cells; altered expression of proteasome-regulatory genes following zif268 induction may be a key component of long-lasting CNS plasticity. | Regulation of neuronal cdc20 (p55cdc) expression by the plasticity-related transcription factor zif268.
Conway AM, James AB, Zang J, Morris BJ. | 01/21/2010 |
| The seven tandem WD motifs of Cdc20 they are required for speriolin binding and for localization of Cdc20 to the centrosomes and nucleus, suggesting that speriolin might regulate or stabilize the folding of Cdc20 during meiosis in spermatogenic cells | Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20.
Goto M, Eddy EM. | 01/21/2010 |
| Data suggest that Mad2 and BubR1 must cooperate to inhibit Cdc20 activity. | Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1.
Davenport J, Harris LD, Goorha R. | 01/21/2010 |
| Cdc20 and securin double mutant embryos could not maintain the metaphase arrest, suggesting a role of securin in preventing mitotic exit | Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos.
Li M, York JP, Zhang P., Free PMC Article | 01/21/2010 |
| Cdc20 is degraded through two independent degradation signals (degrons), the KEN box and a newly described CRY box. | The CRY box: a second APCcdh1-dependent degron in mammalian cdc20.
Reis A, Levasseur M, Chang HY, Elliott DJ, Jones KT., Free PMC Article | 01/21/2010 |