| DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients. | DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
Ghatak S, Satapathy SR, Sjölander A., Free PMC Article | 03/2/2023 |
| Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution. | Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution.
Rabinovitch N, Jones MJ, Gladish N, Faino AV, Strand M, Morin AM, MacIsaac J, Lin DTS, Reynolds PR, Singh A, Gelfand EW, Kobor MS, Carlsten C., Free PMC Article | 01/15/2022 |
| The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children. | The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children.
Zhao M, Li H, Li H. | 11/6/2021 |
| CysLT1R expression on ILC2s and effects of CysLT1R antagonist on ILC2 activity in patients with allergic rhinitis. | CysLT1R expression on ILC2s and effects of CysLT1R antagonist on ILC2 activity in patients with allergic rhinitis.
Qin ZL, Peng YQ, Fang SB, Jiang AY, Li CL, Fan XL, Chen D, Chen WN, Bellanti JA, Zheng SG, Fu QL. | 06/19/2021 |
| Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells. | Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells.
Satapathy SR, Sjölander A. | 01/23/2021 |
| Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells. | Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells.
Koller A, Bruckner D, Aigner L, Reitsamer H, Trost A., Free PMC Article | 01/16/2021 |
| Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1. | Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.
Biagioli M, Carino A, Marchianò S, Roselli R, Di Giorgio C, Bordoni M, Fiorucci C, Sepe V, Conflitti P, Limongelli V, Distrutti E, Baldoni M, Zampella A, Fiorucci S. | 12/5/2020 |
| Drugs antagonizing the CysLT1 receptor, termed lukasts and typified by montelukast, are established therapeutics for clinical management of asthma.. Here we describe recent data indicating that montelukast may be used for prevention and treatment of AAA, thus representing a promising pharmacological tool for a deadly vascular disease with significant socio-economic impact. | Targeting cysteinyl-leukotrienes in abdominal aortic aneurysm.
Araújo AC, Tang X, Haeggström JZ. | 04/13/2019 |
| findings strongly implicate that cysLTR1 has the capacity to regulate cellular senescence in chondrocytes. It is suggested that montelukast may be a potential therapeutic agent for chondro-protective therapy. | Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes.
Song W, Zhang Y, Wang J, Ma T, Hao L, Wang K. | 01/19/2019 |
| The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children | Expression of cysteinyl leukotriene receptor 1 and 2 (CysLTR1 and CysLTR2) in the lymphocytes of hyperplastic tonsils: comparison between allergic and nonallergic snoring children.
Paulucci BP, Pereira J, Picciarelli P, Levy D, Di Francesco RC. | 11/18/2017 |
| SE sensitization may be a risk factor for TH2 inflammation in nonatopic asthma and late-onset asthma and for pulmonary function decline in nonatopic asthma. In women with asthma, a CysLTR1 promoter polymorphism may be associated with SEB sensitization. | Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes.
Matsumoto H, Kanemitsu Y, Nagasaki T, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Izuhara Y, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Hirota T, Kawaguchi T, Tamari M, Yokoyama T, Tabara Y, Matsuda F, Izuhara K, Niimi A, Mishima M. | 08/12/2017 |
| In addition, TGF-beta1-induced expression of MMP-1 and MMP-3, generation of fibronectin and type I collagen production, focal adhesion kinase (FAK) and paxillin phosphorylation in HTFs were also ameliorated by montelukast in a dose dependent manner. These results suggested that montelukast might provide therapeutic possibilities for inhibition of scar formation after such surgery. | The selective cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast regulates extracellular matrix remodeling.
Peng J, Zhou H, Kuang G, Xie L, Tian T, Liu R. | 06/10/2017 |
| CysLTRs -1 and -2 seem to be involved in lymphocyte maturation that occurs in tonsils, without influence of allergies. | Expression of CysLTR1 and 2 in Maturating Lymphocytes of Hyperplasic Tonsils Compared to Peripheral Cells in Children.
Paulucci BP, Pereira J, Picciarelli P, Levy D, di Francesco RC. | 03/11/2017 |
| Data show that cysteinyl leukotriene receptor antagonists (LTRAs) users had a significantly lower cancer incidence rate than LTRA non-users did. | Cysteinyl Leukotriene Receptor Antagonists Decrease Cancer Risk in Asthma Patients.
Tsai MJ, Wu PH, Sheu CC, Hsu YL, Chang WA, Hung JY, Yang CJ, Yang YH, Kuo PL, Huang MS., Free PMC Article | 03/4/2017 |
| in allergen-sensitized individuals, exposure to allergen can enhance T cell expression of CysLT1. This, in turn, would induce enhanced CD4+ T cell responsiveness to cysLTs, T cell activation, and Th2 polarization. | Enhanced cysteinyl-leukotriene type 1 receptor expression in T cells from house dust mite-allergic individuals following stimulation with Der p.
Thivierge M, Turcotte S, Rola-Pleszczynski M, Stankova J., Free PMC Article | 12/5/2015 |
| CysLTR-1 and CysLTR-2 are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH. | [Expression of CysLTR-1 and CysLTR-2 in adenoid tissues from children with adenoid hypertrophy].
Zhu MH, Liang M, Wang ZJ, Shen Y, Wen HY, Zhai JM, Yang XB. | 08/8/2015 |
| The 5-LOX/LTC4 /CysLT1 signaling pathway regulates EGF-induced cell migration by increasing Tiam1 expression. | 5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation.
Magi S, Takemoto Y, Kobayashi H, Kasamatsu M, Akita T, Tanaka A, Takano K, Tashiro E, Igarashi Y, Imoto M., Free PMC Article | 05/10/2014 |
| Cysteinyl leukotrienes signaling downstream of CysLT1R in mast cells is differentially regulated by two distinct PKCalpha and PKC epsilon. | Differential regulation of cysteinyl leukotriene receptor signaling by protein kinase C in human mast cells.
Kondeti V, Duah E, Al-Azzam N, Thodeti CK, Boyce JA, Paruchuri S., Free PMC Article | 04/12/2014 |
| CysLT(1) receptors in endothelial cells translocate to the nucleus in a ligand-independent manner after ischemic insult in vitro, and it is involved in the ischemic injury. | Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells.
Fang SH, Lin KN, Huang XQ, Lu YB, Zhang WP, Wei EQ., Free PMC Article | 11/16/2013 |
| A significant relationship was found between the expression of CysLT1 receptor and GR-beta in nasal polyps (R = .525, P = .04), whereas there was no significant relationship between the expression of CysLT1 receptor and GR-alpha in nasal polyps. | Expression of the cysteinyl leukotriene 1 receptor and glucocorticoid receptor-β in nasal polyps.
An YH, Hong SL, Han DH, Lee CH, Min YG, Rhee CS. | 10/19/2013 |
| Genetic variant may play a role in NSAID induced acute urticaria. | Genetic variants of the arachidonic acid pathway in non-steroidal anti-inflammatory drug-induced acute urticaria.
Cornejo-García JA, Jagemann LR, Blanca-López N, Doña I, Flores C, Guéant-Rodríguez RM, Torres MJ, Fernández J, Laguna JJ, Rosado A, Agúndez JA, García-Martín E, Canto G, Guéant JL, Blanca M. | 06/1/2013 |
| A role of nuclear CysLT(1) receptor signaling in vascular smooth muscle cells inducing gene expression patterns associated with atherosclerosis. | Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression.
Eaton A, Nagy E, Pacault M, Fauconnier J, Bäck M., Free PMC Article | 01/26/2013 |
| Bronchial mucosal CysLT1 receptor-positive inflammatory cells are present in the bronchial mucosa in COPD in greatest number in those experiencing a severe exacerbation. | Cysteinyl leukotriene 1 receptor expression associated with bronchial inflammation in severe exacerbations of COPD.
Zhu J, Bandi V, Qiu S, Figueroa DJ, Evans JF, Barnes N, Guntupalli KK, Jeffery PK., Free PMC Article | 12/8/2012 |
| increased expression in tonsillar tissues of Chinese children with sleep-disordered breathing | Increased cysteinyl leukotriene concentration and receptor expression in tonsillar tissues of Chinese children with sleep-disordered breathing.
Shen Y, Xu Z, Huang Z, Xu J, Qin Q, Shen K. | 11/17/2012 |
| Data suggest that CysLT1 induces chemokine-like effects, supports accumulation and survival of chronic lymphocytic leukemia (CLL) cells in the bone marrow and thus represents a potential treatment target. | The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia.
Drost AC, Seitz G, Boehmler A, Funk M, Norz KP, Zipfel A, Xue X, Kanz L, Möhle R. | 08/25/2012 |