| FoxP1 Represses MEF2A in Striated Muscle. | FoxP1 Represses MEF2A in Striated Muscle.
Steiman S, Miyake T, McDermott JC., | 03/19/2024 |
| Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism. | Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism.
Li X, Hao S, Zou S, Tu X, Kong W, Jiang T, Chen JG., Free PMC Article | 09/28/2023 |
| Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice. | Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice.
Luo X, Hu Y, Zhou X, Zhang C, Feng M, Yang T, Yuan W. | 09/20/2023 |
| Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells. | Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
Ling S, Chen T, Wang S, Zhang W, Zhou R, Xia X, Yao Z, Fan Y, Ning S, Liu J, Qin L, Tucker HO, Wang N, Guo X., Free PMC Article | 08/1/2023 |
| The transcription factor Foxp1 regulates aerobic glycolysis in adipocytes and myocytes. | The transcription factor Foxp1 regulates aerobic glycolysis in adipocytes and myocytes.
Ma H, Sukonina V, Zhang W, Meng F, Subhash S, Palmgren H, Alexandersson I, Han H, Zhou S, Bartesaghi S, Kanduri C, Enerbäck S., Free PMC Article | 07/13/2023 |
| Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1. | Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1.
Zhang J, Roberts JM, Chang F, Schwakopf J, Vetter ML., Free PMC Article | 04/4/2023 |
| Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis. | Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis.
Yang Q, Zhang J, Bao Q, Zhong J, Wang X, Tao Y, Xu X, Lv K, Wang Y, Li B, He L, Guo X, Ma G. | 10/1/2022 |
| Endothelial Foxp1 Regulates Neointimal Hyperplasia Via Matrix Metalloproteinase-9/Cyclin Dependent Kinase Inhibitor 1B Signal Pathway. | Endothelial Foxp1 Regulates Neointimal Hyperplasia Via Matrix Metalloproteinase-9/Cyclin Dependent Kinase Inhibitor 1B Signal Pathway.
Chen X, Xu J, Bao W, Li H, Wu W, Liu J, Pi J, Tomlinson B, Chan P, Ruan C, Zhang Q, Zhang L, Fan H, Morrisey E, Liu Z, Zhang Y, Lin L, Liu J, Zhuang T., Free PMC Article | 08/6/2022 |
| Forkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages. | Forkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages.
Gao F, Zhao Y, Zhang B, Xiao C, Sun Z, Gao Y, Dou X., Free PMC Article | 03/12/2022 |
| Disrupted Mitochondrial Network Drives Deficits of Learning and Memory in a Mouse Model of FOXP1 Haploinsufficiency. | Disrupted Mitochondrial Network Drives Deficits of Learning and Memory in a Mouse Model of FOXP1 Haploinsufficiency.
Wang J, Rappold GA, Fröhlich H., Free PMC Article | 02/26/2022 |
| FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents. | FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents.
Khandelwal N, Cavalier S, Rybalchenko V, Kulkarni A, Anderson AG, Konopka G, Gibson JR., Free PMC Article | 10/16/2021 |
| A novel epigenetic regulation of circFoxp1 on Foxp1 in colon cancer cells. | A novel epigenetic regulation of circFoxp1 on Foxp1 in colon cancer cells.
Luo Y, Liu F, Ma J, Fu Y, Gui R., Free PMC Article | 05/15/2021 |
| Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development. | Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development.
Anderson AG, Kulkarni A, Harper M, Konopka G., Free PMC Article | 03/27/2021 |
| Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates. | Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.
Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajáuregui A, Novitch BG., Free PMC Article | 03/13/2021 |
| An Autism-Related, Nonsense Foxp1 Mutant Induces Autophagy and Delays Radial Migration of the Cortical Neurons. | An Autism-Related, Nonsense Foxp1 Mutant Induces Autophagy and Delays Radial Migration of the Cortical Neurons.
Li X, Han X, Tu X, Zhu D, Feng Y, Jiang T, Yang Y, Qu J, Chen JG. | 10/3/2020 |
| This study revealed that FOXP1-induced CLRN1-AS1 regulated cellular functions in pituitary prolactinoma by sponging miR-217 to release the DKK1/Wnt/beta-catenin signaling pathway. | FOXP1-induced lncRNA CLRN1-AS1 acts as a tumor suppressor in pituitary prolactinoma by repressing the autophagy via inactivating Wnt/β-catenin signaling pathway.
Wang C, Tan C, Wen Y, Zhang D, Li G, Chang L, Su J, Wang X., Free PMC Article | 07/18/2020 |
| Endothelial cell Foxp1 has a role as a novel regulator of endothelial inflammasome activation during atherogenesis. | Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation.
Zhuang T, Liu J, Chen X, Zhang L, Pi J, Sun H, Li L, Bauer R, Wang H, Yu Z, Zhang Q, Tomlinson B, Chan P, Zheng X, Morrisey E, Liu Z, Reilly M, Zhang Y. | 07/11/2020 |
| the expression of the transcription factor Foxp1 gradually increased during the maturation of dendritic cells. | The transcription factor Foxp1 regulates the differentiation and function of dendritic cells.
Guo Z, Tao Y, Yin S, Song Y, Lu X, Li X, Fan Y, Fan X, Xu S, Yang J, Yu Y. | 07/4/2020 |
| Endothelial cells Foxp1 regulates the TGF-beta1-endothelin-1 pathway to control pathological cardiac fibrosis and hypertrophy, resulting in cardiac dysfunction | Endothelial Forkhead Box Transcription Factor P1 Regulates Pathological Cardiac Remodeling Through Transforming Growth Factor-β1-Endothelin-1 Signal Pathway.
Liu J, Zhuang T, Pi J, Chen X, Zhang Q, Li Y, Wang H, Shen Y, Tomlinson B, Chan P, Yu Z, Cheng Y, Zheng X, Reilly M, Morrisey E, Zhang L, Liu Z, Zhang Y. | 05/30/2020 |
| Foxp1 (+/-) mice display altered intestinal motility and achalasia. | Gastrointestinal dysfunction in autism displayed by altered motility and achalasia in Foxp1(+/-) mice.
Fröhlich H, Kollmeyer ML, Linz VC, Stuhlinger M, Groneberg D, Reigl A, Zizer E, Friebe A, Niesler B, Rappold G., Free PMC Article | 04/18/2020 |
| Findings reveal Foxp1 is a master transcriptional repressor of brown/beige adipocyte differentiation and thermogenesis. Molecularly, Foxp1 directly represses beta3-AR transcription and regulates its desensitization behavior. Foxp1-deficient mice show an augmented energy expenditure and are protected from diet-induced obesity and insulin resistance. | Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization.
Liu P, Huang S, Ling S, Xu S, Wang F, Zhang W, Zhou R, He L, Xia X, Yao Z, Fan Y, Wang N, Hu C, Zhao X, Tucker HO, Wang J, Guo X., Free PMC Article | 03/14/2020 |
| Foxp1 plays critical roles in both maintaining T regulatory cell (Treg) quiescence during homeostasis and regulating Treg suppressive function. | Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function.
Ren J, Han L, Tang J, Liu Y, Deng X, Liu Q, Hao P, Feng X, Li B, Hu H, Wang H., Free PMC Article | 12/21/2019 |
| Both Pnoc and FoxP1 were expressed at high levels in the rostromedial tegmental nucleus and colocalized strongly with previously established RMTg markers. FoxP1 was particularly selective for RMTg neurons, as it was absent in most adjacent brain regions. | Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice.
Smith RJ, Vento PJ, Chao YS, Good CH, Jhou TC., Free PMC Article | 06/1/2019 |
| Study found that a large number of Foxp3-bound genomic sites in Treg cells were occupied by Foxp1 in both Treg cells and conventional T cells. In Treg cells, Foxp1 markedly increased Foxp3 binding to these sites. These results suggest that Foxp1 serves an essential non-redundant function in Treg cells by enforcing Foxp3-mediated regulation of gene expression and enabling efficient IL-2 signaling in these cells. | Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function.
Konopacki C, Pritykin Y, Rubtsov Y, Leslie CS, Rudensky AY., Free PMC Article | 05/11/2019 |
| Study quantitatively analyzes the expression pattern of Foxp1 and Foxp2 with respect to specific cell types of projection neurons and interneurons in the striatum of adult mouse brains. Double immunostaining and in situ hybridization showed that Foxp1 and Foxp2 were specifically expressed in striatal projection neurons, but not in interneurons. | Differential and Overlapping Pattern of Foxp1 and Foxp2 Expression in the Striatum of Adult Mouse Brain.
Fong WL, Kuo HY, Wu HL, Chen SY, Liu FC. | 03/30/2019 |